Complement receptors
Binding of Cryptococcus neoformans by human cultured macrophages Requirements for multiple complement receptors and actin
... the receptors on human cultured macrophages (MO-M phi) responsible for binding encapsulated and isogenic mutant acapsular strains of Cryptococcus neoformans, and whether such binding leads to a phagocytic ...with ...
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Relative Impact of Complement Receptors CD21/35 (Cr2/1) on Scrapie Pathogenesis in Mice
... ABSTRACT Complement receptors 1 and 2 (CR1/2 or CD35/CD21) recognize complement-opsonized antigens to initiate innate and adaptive immunity, respec- ...unique complement binding capaci- ties ...
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Human lymphocyte complement receptors Quantitative requirements for C3 of normal and chronic lymphocyte leukemia lymphocytes
... human complement were used to detect lymphocytes with complement receptors from normal subjects and patients with chronic lymphocytic ...on complement-coated erythrocytes were ...
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Neonatal and adult recent thymic emigrants produce IL-8 and express complement receptors CR1 and CR2
... other complement receptors expressed in T cells, C5aR1 and C5aR2, have been ...EBV receptors (CR2 molecules) on T cells highlights a potential pathway of EBV infection that in some cases results in T ...
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Lymphocytes expressing type 3 complement receptors proliferate in response to interleukin 2 and are the precursors of lymphokine activated killer cells
... In the absence of antigenic or mitogenic stimulation, certain peripheral blood lymphocytes exhibit proliferative and lymphokine-activated killer (LAK) cell activities when cultured with recombinant IL-2. Both activities ...
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Phagocytosis of leprosy bacilli is mediated by complement receptors CR1 and CR3 on human monocytes and complement component C3 in serum
... ingestion. Complement receptors CR1 and CR3 also mediate the low level of adherence observed in the absence of ...Serum complement component C3 serves as a ligand on the bacterial surface in monocyte ...
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Internalization of type 1 complement receptors and de novo multivesicular body formation during chemoattractant induced endocytosis in human neutrophils
... Upon activation of human neutrophils by chemoattractants, functionally important proteins are rapidly transported from intracellular granules and storage vesicles to the plasma membrane. This is accompanied by a marked ...
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Interaction of human monocytes, macrophages, and polymorphonuclear leukocytes with zymosan in vitro Role of type 3 complement receptors and macrophage derived complement
... exogenous complement via receptors for iC3b (type 3 complement receptors) acting with or without lectin-like receptors for mannosyl- fucosyl-terminated ...secrete ...
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Deficiency of complement receptors CR2/CR1 in Cr2 -/-mice reduces the extent of secondary brain damage after closed head injury
... potential role of natural IgM, and of CR2-facilitated sig- nal transduction and IgM release by B cells, in contrib- uting to host-mediated secondary neuropathology after closed head injury. Natural antibodies are ...
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Complement independent Adherence of Escherichia coli to Complement Receptors In Vitro
... surface receptors for the third component of complement (C3), but not to erythrocytes from species lacking this ...inhibits complement receptor function, inhibited adherence to human erythrocytes, as ...
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Effect of corticosteroids on the human monocyte IgG and complement receptors
... A quantitative in vitro assay was employed to directly assess the effect of corticosteroids on the IgG and complement receptor function of human mononuclear phagocytic cells. In this system corticosteroids were ...
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Surface expression of Fc gamma receptor III (CD16) on chemoattractant stimulated neutrophils is determined by both surface shedding and translocation from intracellular storage compartments
... Stimulation of neutrophils (PMN) with chemoattractants markedly increases surface expression of several membrane proteins, including the complement receptors, CR1 and CR3, by translocation from ...
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Complement C3a and C5a receptors promote GVHD by suppressing mitophagy in recipient dendritic cells
... Graft-versus-host disease (GVHD) is a major complication of allogeneic hematopoietic cell transplantation (HCT). DCs play critical roles in GVHD induction. Modulating autophagy represents a promising therapeutic strategy ...
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Surface markers of complement receptor lymphocytes
... bearing complement receptors (CRL) were divided into two populations, one expressing both CR1 (C4b-C3b receptor) and CR2 (C3d receptor) and a second expressing only ...Fc receptors, but a qualitative ...
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Neutrophils Interact with Adenovirus Vectors via Fc Receptors and Complement Receptor 1
... alternative complement pathways, including C3 and C4BP (5, 14, ...the complement receptors CR1 (CD35), CR3 (CD11b/CD18, ␣ M  2 ), and CR4 ...
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Preoperative prediction of pediatric patients with effusions and edema following cardiopulmonary bypass surgery by serological and routine laboratory data
... hemolytic complement CH100 by lysis of antibody-coated sheep erythrocytes (The Binding ...The complement fragment ratios C3d/C3, C5a/C5 and immunoglobulin ratio IgE/IgG2, were calculated as measures for ...
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Complement receptor 2–mediated targeting of complement inhibitors to sites of complement activation
... The CR2 fusion proteins inhibited the binding of U937 cells to C3-opsonized erythrocytes. CR2 and CR3 both bind iC3b, and our data indicate that CR2 fusion proteins act as CR3 antagonists, since U937 binding to ...
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Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population
... the complement system. Regardless of the initial pathway, complement activation can lead to the initiation of the terminal pathway (TP) and thereby the generation of C5- convertase, which cleaves C5 in C5a, ...
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G PROTEIN COUPLED RECEPTORS A POTENTIAL NEW DRUG TARGET TO COMBAT DIABETIC SYNDROME: AN OVERVIEW
... protein-coupled receptors (GPCRs), also known as seven-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein-linked receptors (GPLR), ...
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Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome
... between complement activation and thrombophilia in inflammatory ...on complement components because these are ample in the plasma and extracellular fluid; rather, in the absence of neutrophils, there is ...
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