Complement regulatory proteins
Function of complement regulatory proteins in immunity of reproduction: a review
... be complement-fixing or non-fixing and may affect the reproductive functions in a number of ...tion, complement fixation is required for their ...the complement activation might be a “keystone” for ...
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Review Article Targeting complement regulatory proteins in tumor immunotherapy
... The complement system is a vital part of the immune system, and its activation can eliminate malignant tumor ...cells. Complement regulatory proteins (CRPs) can regulate complement ...
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<p>Expression levels of complement regulatory proteins (CD35, CD55 and CD59) on peripheral blood cells of patients with chronic kidney disease</p>
... defective complement regulation or de fi ciencies of particular components lead to various mani- festations of complement-related chronic kidney disease (CKD) and in fl uence its ...the complement ...
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Loss of complement regulatory proteins on uninfected erythrocytes in vivax and falciparum malaria anemia
... these proteins as invasion ligands (27, 28) and highlighting the use of these invasion pathways not only for parasite growth, but also as immune evasion ...functional complement-fixing antibodies or ...
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GPI anchored complement regulatory proteins in seminal plasma An analysis of their physical condition and the mechanisms of their binding to exogenous cells
... (GPI)-anchored proteins, CD59, CD55 (both C regulators), and CDw52, and of the trans- membrane C regulator CD46 in seminal plasma ...GPI-linked proteins eluted at high mo- lecular mass during size exclusion ...
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Loss of complement regulatory proteins on red blood cells in mild malarial anaemia and in Plasmodium falciparum induced blood stage infection
... In Malaysian malaria patients, CRPs on normocytes and reticulocytes were reduced in patients with mildly anaemic P. falciparum and P. vivax infection, suggesting that the removal of CRPs is occurring during early stages ...
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Incorporation of Host Complement Regulatory Proteins into Newcastle Disease Virus Enhances Complement Evasion
... Complement activation in NHS is associated with C3 depo- sition on virions. C3 deposition on a virus or infected cell surface occurs in an amplification loop that results in neutralization by opsonization, ...
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Early and extensive CD55 loss from red blood cells supports a causal role in malarial anaemia
... The results confirm previous findings that CD55 levels on the surface of RBC are lower in children with malar- ial anaemia [4], and in addition indicate that CD55 loss begins early in the course of disease and affects ...
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Expression and localization of proteins of the complement system in human skin
... of complement components that are capable of generating the initial C3 convertase of the alternative ...of complement regulatory proteins could endow keratinocytes with immune functions such ...
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Complement activation in Ghanaian children with severe Plasmodium falciparum malaria
... for complement activation in RBC breakdown dur- ing malaria is supported by reports of positive DCT in patients with anaemia ...the complement cascade and its detrimental role in dis- ease pathogenesis is ...
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Moonlighting Activity of Secreted Inflammation Regulatory Proteins
... secreted proteins from these cells play an important role in the inflammation ...secreted proteins exhibiting multi- functional activities could influence several pathways, indi- cating a highly adapting ...
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A family of tick (Ixodes scapularis) salivary proteins that inhibit complement
... Another reason to co-express multiple ILP family members is that different family members may display host specificity, preferentially binding properdin from specific animal hosts. This is a plausible possibility as ...
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Transcriptional Repression of C4 Complement by Hepatitis C Virus Proteins
... NS5A proteins downregulated C4 promoter activity in a dose-dependent manner ...NS5A proteins exhibited similar levels of suppression of luciferase activity in cells transfected with a plasmid with the ...
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VEGF regulates local inhibitory complement proteins in the eye and kidney
... After administering a single dose of anti-VEGF intravitreally to adult mice, we confirmed reduction in retinal VEGF concentra- tions (Figure 4A) and observed reduced retinal CFH 24 to 48 hours later (Figure 4B, in situ ...
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PROLONGED INTERMITTENT ACTH AND CORTISONE THERAPY IN THE NEPHROTIC SYNDROME; IMMUNOLOGIC BASIS AND RESULTS
... Serum complement, body weight and plasma proteins in a syndrome before and after oral cortisone therapy. D Cortone[r] ...
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Induction of complement proteins in a mouse model for cerebral microvascular Aβ deposition
... that complement components are induced in AD patients and familial CAA patients as well as brains of AD animal models ...by complement acti- vation, amyloid clearance may be promoted by C1q bind- ing to ...
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In vivo roles of Fos-related antigen-2 (Fra-2) in diseased and normal tissue
... The vast number of combinations of the AP-l transcription factors and their interactions with other proteins allows for a complex array of regulatory proteins that control transcription [r] ...
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The diversity of acetylated proteins
... of proteins extends the range of possible mole- cular structures beyond the limits imposed by the 20 encoded amino acids and, if reversible, gives a means of control and ...Many proteins are acetylated, ...
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Mithramycin blocks protein binding and function of the SV40 early promoter
... Our data suggest that mithramycin binds to important regulatory sequences within the SV40 early promoter, blocking binding of regulatory proteins to these sequences resulting in inhibiti[r] ...
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Identification of a third component of complement binding glycoprotein of human platelets
... a complement regulatory protein previously identified on human platelet ...two proteins function conjointly to prevent autologous complement ...
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