Components of the cancer stroma
Cancer–stroma interactions as a target for cancer treatment.
... tumor stroma cells causes a transfor- mation of stromal fibroblasts to ...between cancer cells and oth- er components of stroma might be a target for therapeutic ...and ...
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Tumor-associated macrophages as incessant builders and destroyers of the cancer stroma
... key components of the reactive stroma of ...incessant stroma remodelling favours the release of matrix-bound growth factors and promotes tumor cell motility and ...ECM components are: ...
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Cancer/stroma interplay via cyclooxygenase 2 and indoleamine 2,3 dioxygenase promotes breast cancer progression
... enhance cancer cell migration by degrading ...the cancer- stroma interplay in cancer ...epithelial components of tumor tissues to show their association and to demonstrate the vertical ...
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The footprint of the ageing stroma in older patients with breast cancer
... SASP components described by Coppé et ...the components of the SASP together in the gene enrichment analysis, we indeed confirmed a significant enrichment in SASP genes among genes up- regulated in the ...
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Collagens and Cancer associated fibroblasts in the reactive stroma and its relation to Cancer biology
... of cancer, by CAFs, have also been shown in vivo, where the injection of non-tumorigenic prostate cells, co-cultured with CAFs, lead to the formation of large ...initiating cancer, CAFs have also been shown ...
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Tumor-stroma interaction mediated by tissue transglutaminase in pancreatic cancer
... PDA stroma is composed of diverse components and affected by a complex interplay between the ...targeting stroma can enable tumors to respond more efficiently to chemotherapy, but also can lead to ...
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Emerging concepts in pancreatic cancer medicine: targeting the tumor stroma
... eCM components providing a scaffold for tumor cells, creating barriers for drug delivery, and providing a variety of prosurvival signals for tumor ...tumor stroma, and vessel density is low due to ...
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Emerging concepts in pancreatic cancer medicine: targeting the tumor stroma
... eCM components providing a scaffold for tumor cells, creating barriers for drug delivery, and providing a variety of prosurvival signals for tumor ...tumor stroma, and vessel density is low due to ...
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Mesenchymal stroma: primary determinant and therapeutic target for epithelial cancer.
... chemicals, cancer and, possibly, aging ...important components of the antioxidant response, including peroxiredoxin 1 and 6 ...specific cancer types, including SSC of the esophagus, ...
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Stroma and vessel characteristics in cancer : impact on prognosis and response to treatment
... the cancer cells not only by paracrine interaction but also by establishing tracks in the extracellular matrix and acting as leading cells in a process called collective migration (Gaggioli et ...Breast ...
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Decoding breast cancer tissue–stroma interactions using species specific sequencing
... matrix components were enriched among the genes upregulated in xenografted MCF7 cells, while the cell adhesion category was enriched in the MDA-MB- 231 cells following ...
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Tissue Transglutaminase Mediated Tumor-Stroma Interaction Promotes Pancreatic Cancer Progression.
... of cancer death ...desmoplastic stroma (DS) composed of myofibroblasts and stellate cells which secrete collagens and other matrix proteins that serve as a scaffold on which tumor cells proliferate ...
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Expression of Autotaxin�밚ysophosphatidate Signaling-Related Proteins in Breast Cancer with Adipose Stroma
... breast cancer with adipose stroma. Compared with breast cancer with non-adipose stroma, breast cancer with adipose stroma had higher LPA2 expression of tumor ...breast ...
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Microstructural models for diffusion MRI in breast cancer and surrounding stroma: an ex vivo study
... breast cancer sam- ples were scanned using a wide range of gradient strengths, durations, separations and orienta- ...diffusion components and anisotropy were selected in most cancerous regions and there ...
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Silencing PCBP2 normalizes desmoplastic stroma and improves the antitumor activity of chemotherapy in pancreatic cancer
... PDAC is one of the most lethal carcinomas. The activation of PSCs leads to an intense desmoplastic reaction and is a key characteristic of PDAC. The abnormal accumulation of large amounts ECM components, mostly ...
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Finding Common Ground to Treat Primary and Metastatic Cancer: The Potential of Targeting Tumor Stroma
... matrix components reduced tumor cell proliferation and increased ...tumor stroma are critical to the spatial orientation of tumor ...tumor stroma can limit drug delivery and confer resistance to ...
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Extracellular vesicles swarm the cancer microenvironment: from tumor–stroma communication to drug intervention
... colon cancer cells has also been reported to effect EV cargo composition towards tumor promoting factors including mutated KRAS itself as well as EGFR, SRC family kinases, and integrins, when compared to its ...
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Cancer associated fibroblasts: the architects of stroma remodelling
... , cancer associated fibrob- last ; CAV1 , caveolin 1 ; CDH11 , cadherin 11 ; CLIC , chloride intracellular channel ; CM , conditioned medium ; CTAP , cell-type specific labeling with amino acid precursors ; CXCL12 , ...
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Genomics and proteomics approaches to the study of cancer-stroma interactions
... The product of ARID4A - AT rich interactive domain 4A (RBP1-like) - also known as RBP1 or RBBP1 gene, interacts with the tumor suppressor retinoblastoma (pRB) and histone-modifying complexes, repressing pro- moters of ...
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Pathophysiological role of microRNA-29 in pancreatic cancer stroma
... qPCR analysis. Mature miR-29 family member expression levels were measured by TaqMan MicroRNA Assays (Applied Biosystems) for miR-29a (ID:002112); miR-29b (ID:000413); and miR-29c (ID:000587). U6 snRNA (ID:001973) was ...
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