Components of the tumour microenvironment
An investigation of the relationship between the components of tumour microenvironment, signal transduction pathways and outcome in breast cancer
... The tumour microenvironment is composed of several different cell types including non- immune cells such as fibroblasts, endothelial cells, bone marrow-derived cells, adipocytes, and immune cells such as ...
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The relationship between androgen receptor, components of tumour microenvironment and survival in breast cancer molecular subtypes
... the tumour but also on the interactions between the tumour and the host ...[19]. Components of tumour microenvironment including tumour inflammatory infiltrate and tumour ...
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The relationship between total and phosphorylated STAT1 and STAT3 tumour cell expression, components of tumour microenvironment and survival in patients with invasive ductal breast cancer
... of tumour cells. Tumour hypoxia has been shown to be associated with a more clinically aggressive phenotype, resistance to therapy, angiogenesis Table 4: The relationship between clinicopathological ...
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The relationship between members of the canonical NF-κB pathway, components of tumour microenvironment and survival in patients with invasive ductal breast cancer
... total tumour cell p-p65 compared to nuclear p-p65, total tumour cell p-p65 was associated with more measurements of the local inlammatory ...with tumour grade, tumour stroma percentage, ...
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The relationship between members of the canonical NF-κB pathway, components of tumour microenvironment and survival in patients with invasive ductal breast cancer
... total tumour cell p-p65 compared to nuclear p-p65, total tumour cell p-p65 was associated with more measurements of the local inflammatory ...with tumour grade, tumour stroma percentage, ...
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The hypoxic tumour microenvironment
... major components of the tumour microenviron- ment (TME) are blood vessels, lymphatic vessels, fi bro- blasts, immune cells and chemico-physical components such as the extracellular matrix (ECM) 1 ...
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Role of the Hedgehog pathway in the pancreatic tumour microenvironment
... Pancreatic tumour is a cancer with poor prognosis: there are very few chemotherapeutic agents available to treat it and those available are not ...stromal components are thought to have an important role in ...
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Immune profiling of the tumour microenvironment in prostate cancer
... B7-H3 is a newly discovered member of the B7 family of immune checkpoint molecules with both immune and non-immune functions. I investigated the relationship of B7-H3 to the tumour microenvironment as well ...
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The relationship between tumour budding, tumour microenvironment and survival in patients with primary operable colorectal cancer
... tumor microenvironment had increasing prognostic value in patients with T3 and T4 ...the components of the tumor microenvironment, such as the tumor stroma and inflammatory infiltrate, become more ...
8
Translational aspects in targeting the stromal tumour microenvironment: From bench to bedside
... These components interact via an array of signalling pathways to create an adaptable network that may act to promote or suppress cancer ...the tumour microenvironment is relatively novel and has the ...
13
Tertiary Lymphoid Tissue in Colorectal Cancer: A Key Player in the Tumour Immune Microenvironment
... the tumour (CT), at the invasive margin (IM) of tumour nests and, as it has been recently demonstrated, in adjacent ...the tumour microenvironment, contribute in establishing the biology of ...
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A review on the interactions between the tumour microenvironment and androgen receptor signaling in prostate cancer
... non-cellular components surrounding a tumour termed the ...through tumour associated macrophages also plays a significant role in CaP, for example through enhancing angiogenesis and constructing a ...
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Tumour-on-a-chip: microfluidic models of tumour morphology, growth and microenvironment
... tumor microenvironment in ...controlled microenvironment [99, 110, 112, 120, ...emulated microenvironment, such as chemical gradients and fluid flow at biological relevant speed and ...tumor ...
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Defining the pro-tumour impact of the evolving stromal microenvironment
... to tumour and other stromal ...stromal components have been ...matrix components, in human melanoma, are as extensive as the fibrosis observed in spontaneous BRAF ...
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Modelling the interactions between tumour cells and a blood vessel in a microenvironment within a vascular tumour
... boundaries. The most significant change that occurs when the model is reformulated in higher spatial dimensions relates to the equations governing the blood vessel. In particular, full account must be taken of the blood ...
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Exploring biomarkers from the tumour and the microenvironment in Diffuse Large B-cell Lymphoma.
... Transcripts that had a differential signal value in either the malignant or non- malignant cells were used to build multivariate survival models that were validated in whole GEP data from almost 400 patients. A ...
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Tumour Tissue Microenvironment Can Inhibit Dendritic Cell Maturation in Colorectal Cancer
... individual components of the tumour conditioned media (CCL2, CXCL1, CXCL5) could modulate dendritic cell maturation or cytokine secretion in response to ...conclusion, tumour conditioned media ...
9
Adrenomedullin and tumour microenvironment
... in tumour progression is becoming more relevant with recent ...the tumour cells but also by numerous stromal cells including macrophages, mast cells, endothelial cells, and vascular smooth muscle ...the ...
15
Adapting Immunotherapy to the Tumour Microenvironment
... • Engineer CAR-T cells to synthesise arginine precursors. Strong in vivo efficacy data: enhanced proliferation, increased anti-tumour activity, prolonged survival (publication – PMID:32573723, patent application ...
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Understanding the Role of the Solid Tumour Microenvironment in Brain Tumour Progression
... between studies can most likely be explained by the differences in the methods used to investigate invasion. We have found that cells in three-day-old spheroids are capable of moving up to 214 µm/h, with a mean invading ...
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