CONFER RESISTANCE
Mutations Located outside the Integrase Gene Can Confer Resistance to HIV 1 Integrase Strand Transfer Inhibitors
... IMPORTANCE Integrase strand transfer inhibitors (INSTIs) are increasingly used both as first-line drugs and in rescue therapy because of their low toxicity and high effi- cacy in both treatment-naive and ...
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ABCB1 and ABCC11 confer resistance to eribulin in breast cancer cell lines
... multidrug resistance protein-1 (MRP1) as the second major ABC drug transporter by Cole et ...increased resistance to fluorouracil, whereas increased resistance was not detected for vincristine, ...
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The magnitude of antibiotic resistance to Helicobacter pylori in Africa and identified mutations which confer resistance to antibiotics: systematic review and meta analysis
... overall resistance was ...amoxicillin resistance has been observed in other patho- gens ...high resistance to tetracycline could lead to the failure of novel three-in-one capsule of bismuth quadruple ...
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Diversified mcr 1 Harbouring Plasmid Reservoirs Confer Resistance to Colistin in Human Gut Microbiota
... DNA manipulations. To probe the presence of the mcr-1 gene, all of the bacterial isolates harvested (75 in total [48 for E. coli and 27 for K. pneumoniae]) were screened via PCR-based diagnostics with mcr-1- specific ...
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Mutations in Influenza A Virus Neuraminidase and Hemagglutinin Confer Resistance against a Broadly Neutralizing Hemagglutinin Stem Antibody
... The F10 antibody is an sBnAb derived from the IGHV1-69 germ line by panning phage display libraries generated from healthy donors with immobilized HA; F10 is broadly active against all group 1 viruses and protects mice ...
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Experimental Prediction of the Natural Evolution of Antibiotic Resistance
... one resistance when we started to feel secure about our victory over gene can give rise to many phenotypically diverse de- microbes, antibiotic-resistant strains of bacteria started scendant alleles, protein ...
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PubMedCentral-PMC4912444.pdf
... to resistance due to active site ...to resistance, avoiding such protrusions will minimize the chances of active site mutations that can confer ...DRV resistance; protease needs to extensively ...
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Selection of Mutations in the Connection and RNase H Domains of Human Immunodeficiency Virus Type 1 Reverse Transcriptase That Increase Resistance to 3′-Azido-3′-Dideoxythymidine
... that confer resistance to NRTI have been iden- tified by in vitro passage experiments and from sequences amplified from patients experiencing virologic failure on NRTI ...NRTI-associated resistance ...
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Genome sequences and comparative genomics of two Lactobacillus ruminis strains from the bovine and human intestinal tracts
... ruminis ATCC 27782 genome encodes a number of stress resistance proteins including those predicted to confer resistance to heat, cold, alka- line and phage shock proteins (Additional Fil[r] ...
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Impact of Environmental and Pathogenic Variability on Breaking of Host Rust Resistance in Wheat Cultivars under Changing Climatic Conditions
... rust resistance is not like breeding for better grain quality, higher yield, or even tolerance to physical stresses such as drought or ...rust resistance. Resistance built into a wheat variety over ...
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Malaria vectors resistance to insecticides in Benin: current trends and mechanisms involved
... the resistance is detected for an insecti- cide, other insecticide categories must be used as part of a dynamic resistance ...reducing resistance managing ...create resistance it- self, but ...
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Genetic interactions at the FLA10 locus: suppressors and synthetic phenotypes that affect the cell cycle and flagellar function in Chlamydomonas reinhardtii.
... Although the tubulin genes would be likely targets for mutations that confer resistance to these compounds, genetic mapping and restriction frag- ment length polymorphism[r] ...
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Structure-function analysis of an autoactive derivative of the tomato Cf-9 disease resistance protein
... of resistance proteins is represented by the tomato Cf proteins, which confer resistance to different races of the leaf mould fungus Cladosporium fulvum and includes the Cf-9 protein encoded by one ...
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Widespread vulnerability of Malagasy predators to the toxins of an introduced toad
... domain that shows no evidence of amino acid replacements likely to confer. resistance to bufadienolides[r] ...
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Soybean resistance genes specific for different Pseudomonas syringae avirulence genes are allelic, or closely linked, at the RPG1 locus.
... RPGl and RPMl are disease resistance genes in soybean and Arabidopsis, respectively, that confer resistance to Pseudomonas syringae strains expressing the avirulence[r] ...
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Exosomes Packaging APOBEC3G Confer Human Immunodeficiency Virus Resistance to Recipient Cells
... The human cytidine deaminase APOBEC3G (A3G) is a part of a cellular defense system against human immunodeficiency virus type 1 (HIV-1) and other retroviruses. Antiretroviral activity of A3G can be severely blunted in the ...
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A Method for Amplicon Deep Sequencing of Drug Resistance Genes in Plasmodium falciparum Clinical Isolates from India
... drug resistance in ...and confer resistance to artemisinin in vitro; (ii) mutations in the folate biosynthesis pathway enzymes dihydrofo- late reductase (Pfdhfr) and dihydropteroate synthetase ...
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t-Darpp overexpression in HER2-positive breast cancer confers a survival advantage in lapatinib
... to confer resistance in otherwise trastuzumab-sensitive cells ...trastuzumab resistance [7–10, 17, ...trastuzumab resistance phenotype mediated by t-Darpp ...in resistance to other ...
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Occurrence of Salmonella enterica and Escherichia coli in raw chicken and beef meat in northern Egypt and dissemination of their antibiotic resistance markers
... antibiotic resistance of Salmonella enterica serovars and Escherichia ...antibiotic resistance profiles of ...quinolone resistance genes identified in ...colistin resistance gene mcr‑1 was not ...
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Tomato Plants Overexpressing a Celery Mannitol Dehydrogenase (MTD) Have Decreased Susceptibility to Botrytis cinerea
... effective resistance strategy than induced ex- pression of endogenous ...pathogen resistance, our results confirm and extend the idea that MTD overexpression can be an ef- fective global strategy for ...
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