congenic mice
The influence of the NOD Nss1/Idd5 loci on sialadenitis and gene expression in salivary glands of congenic mice
... two congenic strains heterozygous and homozygous for Idd5 locus by regular SAM analysis, although this had much influence on the severity of ...the congenic mice, although not significantly ...
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Linkage of the Fv-2 gene to a newly reinserted ecotropic retrovirus in Fv-2 congenic mice.
... The observation that these congenic mice differ with respect to the expression of endogenous retroviral sequences and a recent unexpected finding that the endogenous ecotropic virus locu[r] ...
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Isolation of Pasteurella ureae from reproductive tracts of congenic mice
... pneumotropica strains isolated from the uteri of rats and mice were indole negative and mannitol negative 5.. pneumotropica recovered from a contaminated speciflc-pathogen-free, barrier-[r] ...
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Tissue-specific expression of the newly acquired ecotropic Emv-18 provirus in Fv-2 congenic mice.
... To rule out the possibility that the Fv-2s allele is activating in trans transcription from the Emv-2 provirus present in all C57BL mice 17, total spleen RNA from another pair of Fv-2 co[r] ...
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Expression of S100A8 correlates with inflammatory lung disease in congenic mice deficient of the cystic fibrosis transmembrane conductance regulator
... B6-CF mice we previously undertook a study to identify genes having differential expression between 20 day-old lungs (before any indications of an abnormal lung phenotype) of B6-CF and age- and sex- matched ...
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Major histocompatibility complex-conferred resistance to Theiler's virus-induced demyelinating disease is inherited as a dominant trait in B10 congenic mice.
... To determine whether MHCconferred resistance to TMEV-induced demyelination is inherited as a recessive or dominant trait, we infected F1 hybrid progeny mice derived from crosses between [r] ...
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Variation in p30-related proteins in gross virus-induced tumor cell lines derived from H-2 congenic mice.
... In this study, we report that i nonproducer GV-induced cell lines had distinct alterations in gag gene product processing and production, ii cell surface expression of gag protein-relate[r] ...
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Increased susceptibility to collagen induced arthritis in female mice carrying congenic Cia40/Pregq2fragments
... female mice. These effects are significant in congenic B10.Q female mice carrying heterozygous Cia40 fragments of NFR/N ...genic mice carrying heterozygous fragments also show quicker onset of ...
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Dissection of a locus on mouse chromosome 5 reveals arthritis promoting and inhibitory genes
... Genomic DNA was isolated from toe or tail biopsies. The biop- sies were dissolved in 500 μl of 50 mM sodium hydroxide for one to two hours at 95°C, and subsequently neutralised with 100 μl 1 mM Tris-HCl (pH 8). To ...
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B Cells and Antibody Play Critical Roles in the Immediate Defense of Disseminated Infection by West Nile Encephalitis Virus
... C57BL/6J mice with a low-passage WNV isolate from the recent epidemic in New York ...Wild-type mice replicated virus extraneuronally in the draining lymph nodes and spleen during the first 4 days of ...
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Mouse immunoglobulin antibodies require complement for neutralization of mouse retroviruses.
... In addition, we tested sera from NFS congenic mice carrying various other ecotropic murine leukemia virus MuLV-inducing loci 24, 25, as well as sera from adult mice of various inbred and[r] ...
5
Failure To Open the Blood-Brain Barrier and Deliver Immune Effectors to Central Nervous System Tissues Leads to the Lethal Outcome of Silver-Haired Bat Rabies Virus Infection
... SHBRV-17-infected mice to contain the infection, we expect that the BBB should become permeable and immune effector cells reach the cerebellum in addition to the spinal cord prior to the demise of the ...from ...
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Lysosomal β glucuronidase regulates Lyme and rheumatoid arthritis severity
... B6.C3H-Bbaa2 congenic mice exhibited hypo- morphic GUSB enzymatic activity in serum and in cell extracts and supernatants obtained from strain-specific bone marrow– derived macrophages (Figure ...
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Nod1 signaling overcomes resistance of S pneumoniae to opsonophagocytic killing
... parental mice (Figure 6A). Analysis of tissue sections from co-colonized mice, both Nod1 / and parental, showed an intimate association of both Sp (and Hi) with neutrophils in the lateral nasal spaces ...
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Resistance of the target islet tissue to autoimmune destruction contributes to genetic susceptibility in Type 1 diabetes
... Idd9 congenic islet ...Idd9 congenic and NOD mice for analysis by flow ...Idd9 congenic and NOD mice was also determined by confocal microscopy of frozen pancreatic sections ...old ...
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Dose response kinetics of CD8 lymphocytes from young animals transfused into old animals and challenged with influenza
... CD45 congenic mice in our experiments we show that the transfusion of young donor cells into older congenic host animals leads to their successful incorporation into the peripheral T cell ...
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Selection with Recurrent Backcrossing to Develop Congenic Lines for Quantitative Trait Loci Analysis
... become congenic to the recurrent parent except for the QTL of large effect and closely linked regions of the genome, and these regions can be identified using a dense set of markers that differ between the ...
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The non protein coding breast cancer susceptibility locus Mcs5a acts in a non mammary cell autonomous fashion through the immune system and modulates T cell homeostasis and functions
... Mcs5a-resistant congenic and susceptible congenic control female recipi- ents were irradiated to eliminate their bone marrow progenitor cells and grafted with bone marrow cells from either Mcs5a-resistant ...
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Serious limitations of the QTL/Microarray approach for QTL gene discovery
... white adipose tissue (see Methods; data available at the NCBI GEO repository by accession GSE22042). This platform has coverage for 71.7% of 30,388 EntrezGenes in the mm9 genome assembly and for 75.5% of Entrez- Genes in ...
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Pharmacogenomic analysis of retinoic-acid induced dyslipidemia in congenic rat model
... variety of side-effects associated with ATRA therapy in postnatal stages of life have been described both for topical [3] and systemic administration [4]. Serum con- centrations of lipids [5,6], glucose tolerance or bone ...
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