Connexin 43
Connexin 43 acts as a cytoprotective mediator of signal transduction by stimulating mitochondrial KATP channels in mouse cardiomyocytes
... pharmacological actions converge on mitochondrial ATP-sensitive K + (mitoK ATP ) channels and PKC to confer cytoprotection against necrotic and apoptotic cell injury. However, the molecular structure of mitoK ATP ...
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Primordial germ cell deficiency in the connexin 43 knockout mouse arises from apoptosis associated with abnormal p53 activation
... Connexin 43 knockout (Cx43 ␣ 1KO) mice exhibit germ cell deficiency, but the underlying cause for the germ cell defect was unknown. Using an Oct4-GFP reporter transgene, we tracked the distribution and ...
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Reduced Connexin 43 expression is associated with tumor malignant behaviors and biochemical recurrence-free survival of prostate cancer
... anti-Connexin 43 antibody (Cell Signaling Technology, ...final Connexin 43 expression score was calculated using the value of percent positivity score multiply staining intensity score as “-” ...
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Original Article Clinical usefulness of immunohistochemistry for plakoglobin, N-cadherin, and connexin-43 in the diagnosis of arrhythmogenic right ventricular cardiomyopathy
... and connexin-43 immunoreactivity can be used as a significant test in diagnosis of ...and connexin-43 were used for all ...for connexin-43 as well as for ...and ...
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Glucocorticoid impairs cell-cell communication by autophagy- mediated degradation of connexin 43 in osteocytes
... processes. Connexin 43 (Cx43), a major hemichannel protein plays an important role in maintaining dendritic connection between neighboring osteocytes [1, ...
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Original Article Connexin 43 affects intrinsic gefitinib resistance of NSCLC cells by GJIC
... and connexin 43 expression is associated with chemosensi- tivity in neuroblastoma cells ...that Connexin 43 enhances the temo- zolomide resistance of human glioma cells by a GJIC independent ...
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Downregulation of Gap Junctions in Astrocytes by Monoclonal Antibodies against the Second Extracellular Loop of Connexin-43
... Downregulation of gap junctions by monoclonal antibodies against the second extracellular loop of connexin-43 (E2Cx43) was studied in a passaged culture of astrocytes. The results of confocal laser scanning ...
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Original Article Transient downregulation of microRNA-206 protects alkali burn injury in mouse cornea by regulating connexin 43
... family, connexin 43 (Cx43) is known to be expressed in mam- malian cornea and its expression pattern is highly associated with the inflammatory re- sponses in injured cornea [16, ...
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cAMP-Epac Pathway Stimulation Modulate Connexin-43 and MicroRNA-21 Expression in Glioma Cells
... Introduction: Malignant astrocytic gliomas are the most common and lethal brain malignancies due to their refractory to the current therapies. Nowadays, molecular targeted therapy has attracted great attention in ...
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Reduced expressions of connexin 43 and VEGF in the first-trimester tissues from women with recurrent pregnancy loss
... Background: Approximately 45 – 50 % of the recurrent pregnancy loss (RPL) remain(s) unexplained that challenges its clinical management. Formation and development of placenta as well as angiogenesis are critical for ...
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Fluoxetin Upregulates Connexin 43 Expression in Astrocyte
... Introduction: Recent studies have shown that astrocytes play major roles in normal and disease condition of the central nervous system including multiple sclerosis (MS). Molecular target therapy studies in MS have ...
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Astrocytic connexin 43 potentiates myelin injury in ischemic white matter disease
... Rational: Myelin loss is a characteristic feature of both ischemic white matter disease and its associated vascular dementia, and is a hallmark of chronic cerebral hypoperfusion due to carotid artery stenosis. Yet the ...
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Adenovirus-mediated delivery of bFGF small interfering RNA increases levels of connexin 43 in the glioma cell line, U251
... of connexin 43 were detected in U251 cells infected with Ad-bFGF-siRNA at 100 and 50 MOI than in cells infected with Ad-GFP, and the same amount of connexin 43 was detected in Ad-GFP- infected ...
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Evidence for the role of connexin 43 mediated intercellular communication in the process of intracortical bone resorption via osteocytic osteolysis
... Given that global knockout of the Cx43 gene is embryonic lethal [29], we utilized mice with conditional deletion of the gene encoding Connexin 43 (Gja1) specifically in oste- oblasts and osteocytes. Our ...
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Original Article Disturbed expression and distribution of myocardial connexin 43 in sudden death patients with hyperthyroid heart disease
... Myocardial hypertrophy often leads to irrevers- ible changes in cardiac structure and is the independent risk factor of the mortality of car- diovascular diseases [1]. In recent years, the role of junction protein ...
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Connexin 43 expression is associated with increased malignancy in prostate cancer cell lines and functions to promote migration
... of connexin expression in four representative prostate cancer cell lines across the spectrum of ...several connexin subunits were detected in all four cell lines, and connexin 43 (Cx43) showed ...
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Connexin-43 upregulation in micrometastases and tumor vasculature and its role in tumor cell attachment to pulmonary endothelium
... The major conclusion of this study is that gap junctional communication via Cx43 facilitates metastatic homing by increasing the arrest of cancer cells in the lung vasculature. The reduced attachment of cancer cells with ...
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VEGF promotes endothelial progenitor cell differentiation and vascular repair through connexin 43
... the connexin family, connexin 43 (Cx43) is reported to be a major GJ protein in multiple cells and is essential for the regulation of stem cell differentiation [10 – ...
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Effects of ischemic preconditioning on ischemia/reperfusion-induced arrhythmias by upregulatation of connexin 43 expression
... that Connexin 43 (Cx43), the predominant ventricular gap junction protein, is critical for maintaining normal cardiac elec- trical conduction, and its absence in the mouse heart results in sudden arrhythmic ...
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Connexin 43 and metabolic effect of fatty acids in stressed endothelial cells
... Intercellular communication, mediated by special channels named gap junctions (GJ), plays a crucial role in the reg- ulation of the local signals’ transmission and spreading (Mroue et al. 2011). Such a local way of ...
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