Controlled Cortical Impact
Quantitative MRI analysis of brain volume changes due to controlled cortical impact
... of impact to the frontal lobe using quantitative MRI analysis and a mechanical model of penetrating impact ...and controlled cortical impact on deeply-anaesthetized Sprague-Dawley rats, ...
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Administration of S-nitrosoglutathione after traumatic brain injury protects the neurovascular unit and reduces secondary injury in a rat model of controlled cortical impact
... However, major clinical trials with drugs that target only neuroprotection following TBI have proven to be of little efficacy [4]. TBI is a complex disease involving multiple tissues such as vasculature, vascular immune ...
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<p>CPCGI Reduces Gray and White Matter Injury by Upregulating Nrf2 Signaling and Suppressing Calpain Overactivation in a Rat Model of Controlled Cortical Impact</p>
... CCI, controlled cortical impact; NSS, neurological severity score; NS, normal saline; H&E, hematoxylin and eosin; LFB-PAS, Luxol fast blue–periodic acid Schiff; ODs, optical densities; HEPES, ...
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Intravenous multipotent adult progenitor cell therapy after traumatic brain injury: modulation of the resident microglia population
... underwent controlled cor- tical impact (CCI) injury (n = 6/group, 2 groups) or sham injury (n = ...injured cortical hemisphere and overnight incubation in ...underwent controlled ...
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PubMedCentral-PMC5532436.pdf
... FIGURE 1 | Controlled cortical impact (CCI) increases inflammation-associated microRNAs (miRNAs) in the hippocampus. (A) Anatomical characterization of moderate CCI 1, 3, or 7 days post injury (DPI), ...
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Current progress of mitochondrial transplantation that promotes neuronal regeneration
... Studies dated back in 1960s revealed increased number of mitochondria following neuro-axotomy of motor neu- rons [49, 50]. Mitochondrial swelling were observed in isolated sensory ganglions from limb-amputated newt [51] ...
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Human parthenogenetic neural stem cell grafts promote multiple regenerative processes in a traumatic brain injury model
... Cell-based therapy may be a viable method of ameliorating the negative effects of TBI. Human pluripotent stem cells such as human parthenogenetic stem cells (hpSCs) are enticing because they are capable of limitless ...
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A Review of Traumatic Brain Injury Animal Models: Are We Lacking Adequate Models Replicating Chronic Traumatic Encephalopathy?
... a controlled cortical impact (CCI) TBI model entails the use of a mechanically actuated ...the impact can be ...to impact (Figure 4). The CCI model produces a pronounced cortical ...
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Merging pathology with biomechanics using CHIMERA (Closed-Head Impact Model of Engineered Rotational Acceleration): a novel, surgery-free model of traumatic brain injury
... and controlled cortical impact (CCI) systems, and closed-head injury (CHI) models that use either gravity or mechanical methods to impact the intact skull (reviewed in ...to impact ...
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Astrocyte Signaling in Traumatic Brain Injury
... mild controlled cortical impact (mCCI) to current CCI injury models we show the impact of varying strain rate on ...The impact depth of mCCI was double the CCI impact depth used ...
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Biomechanical analysis of open-skull high-rate traumatic brain injury using finite element mouse brain model
... To better understand traumatic brain injury (TBI), it is necessary to correlate with injuries, which are observed from in vivo laboratory experiments, to brain mechanical responses, which can so far be best predicted by ...
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Neurofeedback in children with attention-deficit/hyperactivity disorder (ADHD) – a controlled multicenter study of a non-pharmacological treatment approach
... randomized, controlled trial with parallel groups is to examine the efficacy of neuro- feedback in comparison to a self-regulation training using a peripheral physiological parameter, controlling for pos- sible ...
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Decreased Thickness of Primary Motor Cortex in Primary Lateral Sclerosis
... in cortical thickness between the PLS group and the control subjects ...in cortical thickness across the ...the cortical gray matter in any individual patient, even when using ...
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Assessing the impact of impulsivity on working memory performance and frontal cortical arousal
... Results: The results revealed that the groups had no significant differences in working memory performance, but impulsive subjects performed the tasks with less reaction time and with more errors. The results of alpha ...
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Cortical reorganisation of cerebral networks after childhood stroke: impact on outcome
... To our knowledge, only Dinomais et al. (2012) have published results of rsfMRI in paediatric AIS patients [27]. The authors applied rsfMRI to a relatively small sample of children after neonatal stroke and analysed the ...
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Proteomic Analysis Reveals Selective Impediment of Neuronal Remodeling upon Borna Disease Virus Infection
... functions controlled by cytoskeleton-binding proteins and their possible link with other identified proteins, such as synapsin or MARCKS, it is plausible that the identified changes may impact neuronal ...
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Identification and immunophenotype of abnormal cells present in focal cortical dysplasia type IIb
... Patients were evaluated at the Ribeirão Preto Epilepsy Surgery Program (CIREP) at Ribeirão Preto Medical School, University of São Paulo, SP, Brazil, at the Porto Alegre Epilepsy Surgery Program, Porto Alegre, Brazil, ...
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Bilateral enucleation alters gene expression and intraneocortical connections in the mouse
... the impact of the removal of a sensory receptor surface on arealization in an elegant series of very early postnatal enucleation experiments in Mono- delphis ...somatosensory cortical areas into visual ...
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Impact of pharmacist intervention on adherence and measurable patient outcomes among depressed patients: a randomised controlled study
... randomised controlled study with a 6-month follow-up, beginning by randomly grouping participants into either: 1) the intervention group (IG; usual pharmacy services plus pharmacist intervention based on SDM); or ...
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The impact of patient , disease , and treatment related factors on survival in patients with adrenocortical carcinoma
... Adrenal cortical carcinoma (ACC) is a rare tumour with a worldwide incidence of 2 per million people, and is responsible for 0.2% of all cancer deaths. It is one of the most aggressive endocrine tumours. 1 Due to ...
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