convergent extension
XNF ATc3 affects neural convergent extension
... Convergent extension is the primary driving force elongating the anteroposterior body ...Xenopus, convergent extension occurs in the dorsal mesoderm and posterior neural ectoderm, and is ...
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Regulation of cochlear convergent extension by the vertebrate planar cell polarity pathway is dependent on p120 catenin
... The vertebrate planar cell polarity (PCP) pathway consists of conserved PCP and ciliary genes. During development, the PCP pathway regulates convergent extension (CE) and uniform orientation of sensory hair ...
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Chato, a KRAB zinc finger protein, regulates convergent extension in the mouse embryo
... A decrease in the number of cells across the width of the definitive endoderm could be the result of mediolateral cell intercalation. However, this number could also be influenced by proliferation, apoptosis and ...
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Inhibition of the cell cycle is required for convergent extension of the paraxial mesoderm during Xenopus neurulation
... in convergent extension (Keller, 2002; Wallingford et ...examined convergent extension by comparing the ability of dorsal explants from CMO (n=21) or ...explant extension compared with ...
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Dual roles of zygotic and maternal Scribble1 in neural migration and convergent extension movements in zebrafish embryos
... knockout mice, r4-derived nVII motor neurons fail to migrate caudally (Studer et al., 1996). In chick hindbrain, they fail to migrate caudally and form a nucleus at r4. However, replacement of r5 or r6 with that of mouse ...
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Epidermal growth factor signalling controls Myosin II planar polarity to orchestrate convergent extension movements during Drosophila tubulogenesis
... Most epithelial tubes arise as small buds and elongate by regulated morphogenetic processes including oriented cell division, cell rearrangements, and changes in cell shape. Through live analysis of Drosophila renal ...
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Convergent extension: using collective cell migration and cell intercalation to shape embryos
... Convergent extension (CE) is a key process by which tissues undergo narrowing along one axis and concomitant extension along another axis. The first identified and best-studied example of CE in ...
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TRIM28 is required by the mouse KRAB domain protein ZFP568 to control convergent extension and morphogenesis of extra embryonic tissues
... chatwo mutants were isolated in an ENU mutagenesis screen for recessive mutations affecting development of the mid-gestation mouse embryo. Embryos homozygous for chatwo arrested prior to E9 with severe convergent ...
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Roles of Wnt pathway genes wls, wnt9a, wnt5b, frzb and gpc4 in regulating convergent extension during zebrafish palate morphogenesis
... The Wnt signaling pathway is crucial for tissue morphogenesis, participating in cellular behavior changes, notably during the process of convergent-extension. Interactions between Wnt-secreting and ...
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Force production and mechanical accommodation during convergent extension
... To quantify the forces driving convergent extension we developed a method to measure force using an agarose gel as a force sensor. Agarose has been used to culture cells and tissues and its mechanical ...
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Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation
... that convergent extension in Xenopus and zebrafish requires several proteins whose homologs are involved in establishing PCP in fly, suggesting that a mechanism highly similar to the PCP pathway regulates ...
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PTK7 is essential for polarized cell motility and convergent extension during mouse gastrulation
... Despite being implicated as a mechanism driving gastrulation and body axis elongation in mouse embryos, the cellular mechanisms underlying mammalian convergent extension (CE) are unknown. Here we show, with ...
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Lrp6 is required for convergent extension during Xenopus gastrulation
... neural convergent-extension defects in embryos, animal caps and Keller sandwiches ...regulates convergent-extension activity in the same direction as the full-length intracellular domain ...
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Do lamellipodia have the mechanical capacity to drive convergent extension?
... ABSTRACT Convergent extension (CE), a kinematic motif associated with several important morphogenetic movements in embryos, entails narrowing of a tissue in one in-plane direction and elongation in the ...
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XIer2 is required for convergent extension movements during Xenopus development
... in convergent extension? We have previously shown in zebrafish that ier2 is a target gene of Fgf signaling, and is critical in the transmission of the Fgf signal during formation of Kupffer’s vesicle, and ...
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αE-catenin-dependent mechanotransduction is essential for proper convergent extension in zebrafish
... impaired convergent extension movements during gastrulation and have indeed been observed in embryos of well-established CE regulators such as Wnt/PCP signaling (Topczewski et ...
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FGF3 in the floor plate directs notochord convergent extension in the Ciona tadpole
... RESULTS AND DISCUSSION Non-MAPK FGFR signaling is required for notochord convergent extension In tadpoles of Ciona intestinalis, the notochord is composed of a single row of 40 cells tha[r] ...
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Frizzled 2 and frizzled 7 function redundantly in convergent extension and closure of the ventricular septum and palate: evidence for a network of interacting genes
... the convergent extension phenotype, in which case the microarray analysis at ...the convergent extension ...–/– convergent extension phenotype is a ...
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Convergent extension movements in growth plate chondrocytes require gpi anchored cell surface proteins
... Gpi-anchored proteins regulate tissue polarity The fact that Piga null cells eventually pass through all phases of chondrocyte maturation while defects in cell shape and cell arrangement[r] ...
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Dynamin dependent endocytosis is necessary for convergent extension movements in Xenopus animal cap explants
... ABSTRACT Cadherin cell-cell adhesion molecules are important determinants of morphogenesis and tissue patterning. C-cadherin plays a key role in the cell-upon-cell movements seen during Xenopus gastrulation. In ...
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