COPOLYMER MICELLES
Decoration of pH-sensitive copolymer micelles with tumor-specific peptide for enhanced cellular uptake of doxorubicin
... In vitro cytotoxicity of DOX, HTM, and PHTM was tested against MCF-7 cells and MDA-MB-231 cells. As shown in Figure 3B, HTM and PHTM showed significant higher cytotoxicity than free DOX (P,0.05). The IC 50 values of HTM ...
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Blending block copolymer micelles in solution ; obstacles of blending
... preparation pathway on the self-assembly. Moreover, after the heating cycle no changes in the micelle structures were observed for either assembly pathway (see ESI † for cryo-TEM analysis). This lack of rearrangement ...
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Passive targeting of thermosensitive diblock copolymer micelles to the lungs: synthesis and characterization of poly(N-isopropylacrylamide)-block-poly(ε-caprolactone)
... DiR-loaded micelles largely accumulated in the lungs, the nanocarriers delivered a higher carbo- platin amount to this organ as compared to the ...by micelles is dependent on the loaded mol- ...
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Doxorubicin-loaded PEG-PCL copolymer micelles enhance cytotoxicity and intracellular accumulation of doxorubicin in adriamycin-resistant tumor cells
... doxorubicin-loaded micelles for three days at doxorubicin concentrations of 3–12 µ g/mL (P ...drug-loaded micelles when compared with doxorubicin solution at a concentration of 6–12 µ ...the micelles ...
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Study of block copolymer micelles as vehicles for hydrophobic drug Lamotrigine
... F68 micelles and their mixed polymeric ...Pluronic micelles were evalu- ated at pH 8 and 6 over 6 hours by a simple diffusion method & were shown in ...Lamotrigine micelles after 6hours at pH 6 ...
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Fluorescent block copolymer micelles that can self report on their assembly and small molecule encapsulation
... polymer micelles derived from intrinsically fl uorescent copolymers has also been observed by detecting a decrease in emission, 26 while the loss of mobility upon BCP micelle gelation has allowed for the glass ...
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Copolymer micelles function as pH-responsive nanocarriers to enhance the cytotoxicity of a HER2 aptamer in HER2-positive breast cancer cells
... Abstract: Efficient delivery of nucleic acids into target cells is crucial for nucleic acid-based therapies. Various nucleic acid delivery systems have been developed, each with its own advan- tages and limitations. We ...
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Increased Oxygen Solubility in Aqueous Media Using PEG–Poly-2,2,2-trifluoroethyl Methacrylate Copolymer Micelles and Their Potential Application As Volume Expanders and as an Artificial Blood Product
... Our principle aim was to develop a system that could overcome the problems of using small perfluoro compounds that necessitated the use of emulsions. To achieve this we decided to synthesize and test a series of ...
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Curcumin Encapsulated Alginate/Pluronic Block Copolymer Micelles as a Promising Therapeutic Agent
... tri-block copolymer P123 micelles has the potential for the formulation of ...the micelles effectively trap-free curcumin as evidenced by analytical ...drug-encapsulated micelles were ...
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Determination of Effective Particle Density for Sterically Stabilized Carbon Black Particles: Effect of Diblock Copolymer Stabilizer Composition
... The e ff ective densities of the resulting sterically stabilized carbon black particles are calculated from geometric consid- erations, assuming (i) a spherical core − shell morphology and (ii) that the star-like diblock ...
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Comparison of pseudo-living character of RAFT polymerizations conducted under homogeneous and heterogeneous conditions
... diblock copolymer nanoparticles are not too large, the small refractive index di ff erence between the PTFEMA cores and ethanol leads to minimal light ...diblock copolymer and erroneously high ...
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Live cell tracking of symmetry break in actin cytoskeleton triggered by abrupt changes in micromechanical environments
... triblock copolymer micelles, we monitored the morphological dynamics of myoblast (C2C12) cells in response to an abrupt change in the substrate elasticity by live cell ...
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The Copolymer blending method : a new approach for targeted assembly of micellar nanoparticles
... simple copolymer blending method has been utilized to produce a range of polymeric micelles in aqueous ...polymeric micelles with varying intermediate hydrophobic ...blended micelles were ...
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The Community Rating System: Assessing Indicators of Community Participation, A Dasymetric and Sovi Approach
... In this chapter, PMT derived tunable isomorphic nanomaterials were used as model systems to study the charge storage mechanism at different length scales. The PMT is a unique technique which forms kinetically entrapped ...
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Interaction of Nickel-Dipeptide Complex with Ninhydrin in Aqueous and Micellar Media
... cationic micelles (CTAB) on the reaction of [Ni(II)-Gly-Leu] + complex with ninhydrin and to check whether CTAB micelles change the aqueous reaction ...
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Branching out with CCTP : the synthesis of branched functional polymers
... FIGURE 5.30: SEC COMPARISON OF COPOLYMER B WITH B3 THIOL-MICHAEL ADDITION AND B3 DUAL FUNCTIONALISED B: EGDMA/GMA COPOLYMER 50/50 MOL%, B3 THIOL-MICHAEL ADD.: COPOLYMER B FUNCTIONALISED [r] ...
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A novel diblock copolymer of (monomethoxy poly [ethylene glycol]-oleate) with a small hydrophobic fraction to make stable micelles/polymersomes for curcumin delivery to cancer cells
... (0 mg, 2 mg, 4 mg, 6 mg, 8 mg, 12 mg, 16 mg, 20 mg, and 25 mg) and mPEG-OA copolymer (100 mg) were codissolved in 3 mL of acetone in different glass tubes. Then, 3 mL of water was added to each tube with constant ...
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A Semantic Approach of ITS: Perspective on Road Safety
... procedure decreases the oxidation stability of the oil and increases its tendency to deposit carbon. Addition of PPDs to the base oil is a reasonable solution to this problem. There are some characteristics of additives ...
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Comparative Study of Pure Micelles and Mixed Micelles in the presence of Polymer
... mixed micelles are considered to be more versatile than single surfactants in view of their wide industrial applications and hence the evaluation of their physiochemical properties has recently attracted a lot of ...
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Self-assembled micelles based on pH-sensitive PAE-<em>g</em>-MPEG-cholesterol block copolymer for anticancer drug delivery
... novel copolymer displayed pH sensitivity as well as the results of the potentiometric ...the micelles was significantly accelerated with pH decreasing from ...DOX-loaded micelles was similar to that ...
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