copy number aberrations
DNA Copy Number Aberrations, and Human Papillomavirus Status in Penile Carcinoma. Clinico-Pathological Correlations and Potential Driver Genes
... DNA copy number aberrations found in HPV-positive and HPV-negative PSCCs, and demon- strated that these tumors display similar patterns of genetic aberrations despite the distinct pathogenetic ...
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DiNAMIC - a method for assessing the statistical signficance of DNA copy number aberrations
... DNA copy number aberrations (CNAs) are commonly found in tumor tissue, and can range from losses (deletions) of one or both copies of chromosomal regions to gains of numer- ous additional copies ...
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Identification of novel pathogenic copy number aberrations in multiple myeloma: the Malaysian context
... TaqMan® Copy Number Assay and a VIC® dye-labeled TaqMan® Copy Number Reference ...the copy number of the targeted of ...> Copy number > 2.5 will be called as ...
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Epidermal Growth Factor (EGFR) copy number aberrations in esophageal and gastro-esophageal junctional carcinoma
... EGFR copy number gain, including amplification, in esophageal and gastric cancers has been identified using several different methods, which used differing levels of gain for reporting EGFR amplification ...
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Reduced rate of copy number aberrations in mucinous colorectal carcinoma
... DNA copy number profiles was assessed by calculating the median absolute deviation (MAD) from the log2ratios of signal intensities from tumor- and paired germ-line ...DNA copy number profiles ...
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Gefitinib and EGFR Gene Copy Number Aberrations in Esophageal Cancer.
... including copy number gain (CNG) of ...somatic copy number alterations occur frequently in esophageal adenocarcinoma and squamous cell ...
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Tumor heterogeneity in neoplasms of breast, colon, and skin
... genomic aberrations from the previous subpo- ...of aberrations in the previous loci) based on the previous ...detect copy number aberrations, the heterogeneity model does not consider ...
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Complexity and algorithms for copy-number evolution problems
... Copy number aberrations include segmental deletions and amplifications that affect large genomic regions, and are common in many cancer types ...the number of copies of genomic regions (posi- ...
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Phospholipase C gamma 1 (PLCG1) R707Q mutation is counterselected under targeted therapy in a patient with hepatic angiosarcoma
... of copy number aberrations (CNAs) of the primary tumor to the skin metastatic lesion that developed after progression on sunitinib, revealed high- level amplification of the ...
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Evaluation of the Genomic Aberrations in Canine Osteosarcoma and their Resemblance to the Human Counterpart.
... that copy number aberrations are associated with structural alterations in the OS ...and copy number gains of MYC have been confirmed previously in canine OS (Thomas et ...demonstrated ...
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Time series analysis of neoadjuvant chemotherapy and bevacizumab-treated breast carcinomas reveals a systemic shift in genomic aberrations
... treatment. Copy number alterations (CNAs) may be useful markers to follow tumor clonality in heterogeneous ...of copy number aberrations in tumor DNA during treatment of breast cancer ...
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Detection Of Copy Number Variations In Genomic Regions
... detect copy number ...(total number of tumor reads)/(total number of normal reads) is ...observed. Copy number alterations is there where the read ratio varies from the expected ...
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Cytogenomic profiling of breast cancer brain metastases reveals potential for repurposing targeted therapeutics
... amplitude copy number aberrations as opposed to those that were recurrent, the numbers of analyzed genes mapping to this pathway increased, to include SOX2, PIK3CA, NTRK1 as well as GNAS, CTNNB1, and ...
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Next generation sequencing
... mutations, copy number aberrations and somatic rearrange- ments in cancer genomes, the information accrued by massively parallel sequencing of breast cancers may lead to a paradigm shift in the way ...
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Deletion of chromosome 4q predicts outcome in Stage II colon cancer patients
... obstruction, number of nodes harvested and presence of lymph node micro metastasis have all been identified as negative prognostic factors in stage II colon cancer [16, 22, ...for copy number ...
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Cyclin E1 and RTK/RAS signaling drive CDK inhibitor resistance via activation of E2F and ETS
... pathway aberrations found across many different cancer types ...novo copy number aberrations that are upstream of cyclin D or cyclin E: Copy number gain and overexpression of ...
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Original Article High-resolution array based heterogeneity and clonality profiling of oral squamous cell carcinoma: genetic relationship between metastatic primary tumor and the paired lymph node metastases
... genome. This kind of array identifies tumor-sup- pressive genes which are located in compara- tive genomic hybridization and thus identify re- gions of tumor-suppressive or oncogenic genes in OSCC [26-30]. However, ...
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Copy number variation in the Framingham Heart Study
... Table 1 presents a summary of the results for the GADA and CNAM analyses for each chromosome. No gene attains genome-wide significance when tested for asso- ciation between copy number and diabetes. ...
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Understanding the impact of 1q21.1 copy number variant
... expression/1q21.1 copy number correlation, encodes the b2-subunit of AMPK, a key regulator of cellular response to a large number of external stimuli which modulates energy levels at the cellular and ...
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Ty1 Copy Number Dynamics in Saccharomyces
... Ty1 copy number and chro- mosomes using the numbering system developed for the Ty-less mosomal occupancy were determined by Southern analy- strain by Moore et ...
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