copy number alterations (CNAs)
High-resolution analysis of copy number alterations and associated expression changes in ovarian tumors
... compare copy number alterations (CNAs) in fresh- frozen ovarian tumor samples, of several subtypes, from 52 ...of CNAs from pri- mary and metastatic samples as well as those in ...
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Two classes of intrahepatic cholangiocarcinoma defined by relative abundance of mutations and copy number alterations
... of CNAs are shown in Figure ...of CNAs are observed in the cases with less number of somatic mutations ...or CNAs, can classify the cases into five M and C classes, as primarily driven by ...
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Histotype-specific copy-number alterations in ovarian cancer
... significant copy number altered regions, we used a 2-pronged workflow employing the GISTIC algo- rithm ...identifies copy number alterations based on the frequency as well as the log ...
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Review Article Copy number alterations in colorectal cancer
... somatic CNAs, namely, the amplification of oncogenes or deletion of tumor suppressor genes ...recurrent CNAs in tumor/metastasis genomes are believed to have a high possibility of containing malignant genes ...
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Importance of rare gene copy number alterations for personalized tumor characterization and survival analysis
... Our conclusions rest on two computational models: the first, CCTN, describes transcriptional regulatory relation- ships between genes in a tumor context, i.e. in fast pro- liferating cells, but independent of a specific ...
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High resolution genomic and expression analyses of copy number alterations in HER2 amplified breast cancer
... complex CNAs in HER2+ BC, often involving other high- level amplifications together with the 17q12 locus [18- ...and copy number lev- els, including genes and miRNAs implicated in BC oncogenesis like ...
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Chromosomal instability and copy number alterations in Barrett’s esophagus and esophageal adenocarcinoma
... in CNAs, which is less than one-quarter of the changes required by flow ...and CNAs at a much higher density than BAC arrays would be the most direct means of extending this study to a larger number ...
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Chromosomal copy number alterations for associations of ductal carcinoma in situ with invasive breast cancer
... A number of studies have previously examined the risk of DCIS recurrence using protein expression markers [16]; however, DNA copy number changes are common in early genomic lesions and may serve as ...
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Genome-wide copy number alterations in subtypes of invasive breast cancers in young white and African American women.
... Hierarchical clustering was performed with the 320 statistically significant differential BAC clones that were identified in the subgroup comparisons. We were interested in determining if breast cancer subtypes would ...
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Landscape of somatic allelic imbalances and copy number alterations in HER2 amplified breast cancer
... and CNAs, as well as higher occurrence of subclonal CN loss events irrespective of BC subtype (Figure 2F and Additional file ...LOH, CNAs and CNN-AI across HER2-amplified and HER2-negative tumors appear ...
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Copy number alterations detected by whole-exome and whole-genome sequencing of esophageal adenocarcinoma
... frequent CNAs in 15 EA patients using BAC array data ...Tumorscape Copy Number Portal, where they collected more than 3000 copy number profiles from 26 cancer types using Affymetrix ...
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Coexistence of iAMP21 and ETV6-RUNX1 fusion in an adolescent with B cell acute lymphoblastic leukemia: literature review of six additional cases
... for copy number alterations (CNAs) and copy-neutral loss of heterozygos- ity (cnLOH) were analyzed using Affymetrix Chromo- some Analysis Suite ...Nexus copy number ...of ...
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DNA copy number alterations and PPARG amplification in a patient with multifocal bladder urothelial carcinoma
... low-level copy num- ber gain including the locus of ASCL1 in almost all the tumor samples we examined, especially in the ...possible alterations of ASCL1 mRNA using more sensitive techniques as RT-PCR or ...
8
Time series analysis of neoadjuvant chemotherapy and bevacizumab-treated breast carcinomas reveals a systemic shift in genomic aberrations
... treatment. Copy number alterations (CNAs) may be useful markers to follow tumor clonality in heterogeneous ...allele-specific CNAs, as well as the clonal composition of tumors (the ...
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Molecular analysis of cell-free DNA identifies distinct molecular features in patients with chemosensitive and chemorefractory small cell lung cancer
... survival; CNAs: copy number alterations; APC: adenomatous polyposis coli; TP53: tumor protein 53; ATM: ataxiatelangiectasia mutated; FLCN: folliculin; PCA: principal component analysis; SH2D5: ...
5
PubMedCentral-PMC5777758.pdf
... substantial number of individuals never responded to ...and copy number alterations (CNAs) associated with resistance to multi-targeted TKIs across tumor ...
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Genomic differences between pure ductal carcinoma in situ and synchronous ductal carcinoma in situ with invasive breast cancer
... genomic alterations remain ...and copy number profiling for six cases of pure DCIS and five pairs of synchronous DCIS and ...AKT1), copy number alterations (CNAs) and ...
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Evidence-based genomic diagnosis characterized chromosomal and cryptic imbalances in 30 elderly patients with myelodysplastic syndrome and acute myeloid leukemia
... genomic alterations in patients with MDS and AML ...segmental copy number alterations (CNAs), we have performed aCGH analysis on 30 MDS and AML cases with different clonal ...
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Bioinformatics-based identification of miR-542-5p as a predictive biomarker in breast cancer therapy
... databases. Copy-number alterations (CNAs) of SFRP1 confer survival disadvantage to breast cancer patients and alter the mRNA expression of SFRP1 in cBioPortal ...
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Overexpression of MAPK15 in gastric cancer is associated with copy number gain and contributes to the stability of c-Jun
... Genome-wide copy number alterations (CNAs) were first investigated in 40 gastric cancers using Agilent aCGH-244K or aCGH-400K, and copy number gains of MAPK15 found in aCGH were ...
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