Cortical Development
Multivoxel Proton MR Spectroscopy in Malformations of Cortical Development
... of cortical development (MCD) are congen- ital anomalies of the brain that are genetically programmed and/or a result of insults during proliferation, migration, and or- ganization of neuronal ...
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Epileptogenic malformations of cortical development: when evolution goes awry
... axon) setting a polarization; this leading neurite extends and contracts as it explores the microenvi- ronment, and the cell can extend multiple processes with even transient polarity reversals (4); (2) trans- location ...
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Dysregulation of the (immuno)proteasome pathway in malformations of cortical development
... of cortical development (MCD; focal cortical dysplasia (FCD) IIa and b, cortical tubers from patients with tuberous sclerosis complex (TSC), and mild MCD ...
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Cortical development: the art of generating cell diversity
... during cortical development to ensure the generation of proper neuronal and non-neuronal cell numbers, but how this is molecularly regulated still remains ...
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The evolution of cortical development: the synapsid diapsid divergence
... for cortical development is underpinned by the identification of genes that are implicated in human hereditary primary microcephaly (MCPH) and related disorders (see Table 1 and references ...to ...
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Insights From Pretzel Syndrome: The Role of STRADA in Neuronal Migration and Cortical Development
... of cortical development results in a failure of Tsc-deficient neurons to reach their intended destination of CP layers II/III, adjacent to pia (62, ...of cortical neurons, possibly through ...
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Long-Term Outcome of the Ketogenic Diet for Intractable Childhood Epilepsy With Focal Malformation of Cortical Development
... METHODS. A retrospective analysis evaluated seizure outcomes of 47 patients who had intractable epilepsy from (and) surgically remediable focal malformation of cortical development and were first treated ...
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The role of [alpha]3[beta]1 integrin in cortical development
... of cortical neurons following neuronal migration, since α3 integrin inactivation by Parvalbumin-Cre is restricted to a subset of cortical ...during cortical development, which is highest ...
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The Arcuate Fasciculus and Language Development in a Cohort of Pediatric Patients with Malformations of Cortical Development
... focal cortical dysplasia (n ⫽ 15), schiz- encephaly (n ⫽ 4), and gray-matter heterotopia (n ⫽ ...focal cortical dysplasia, 3 with schizencephaly); and 5 had profound impair- ment (3 with polymicrogyria, 1 ...
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The Role of TSC2 and Deptor in Fetal Cortical Development
... homologous cortical regions (n=5 embryos per condition; 3-8 rostral to caudal sections per embryo were ...and cortical plate (CP), were defined by the density of Hoechst-positive ...
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M1 muscarinic receptor for the development of auditory cortical function
... of cortical development the expression (mRNA) levels of most nAChRs are constant, whereas those of mAChRs vary, having peak periods within the first several weeks of postnatal life that correspond with ...
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miRNAs are essential for survival and differentiation of newborn neurons but not for expansion of neural progenitors during early neurogenesis in the mouse embryonic neocortex
... mouse cortical development, early-born neurons ...deep cortical layers, notably layer VI, which contains strongly Tbr1- positive neurons (Hevner et ...
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Development of cortical thickness and surface area in autism spectrum disorder
... in cortical vol- ume. The constituents of cortical volume – cortical thickness and surface area – have separable developmental trajectories and are related to different neurobiological ...of ...
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Jha_unc_0153D_17406.pdf
... Our studies fill an important gap in the understanding of how genetic influences shape cortical thickness and surface area during a critical yet understudied period of development. In contrast to the ...
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Effect of malaria in pregnancy on foetal cortical brain development: a longitudinal observational study
... between women with immediately treated malaria infec- tions and non-infected pregnancies was detected. Of all graded sulci, only the cingulate sulcus matured faster in foetuses of women affected by malaria during ...
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Autism-associated CHD8 deficiency impairs axon development and migration of cortical neurons
... in cortical development is dynamic and epigenetically modulated [38], it is also conceivable that CHD8 may have different roles at the different stages of fetal brain ...
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Sequential egocentric navigation and reliance on landmarks in Williams syndrome and typical development
... Visuospatial difficulties in Williams syndrome (WS) are well documented. Recently, research has shown that spatial difficulties in WS extend to large-scale space, particularly in coding space using an allocentric frame of ...
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PAR3 is essential for cyst mediated epicardial development by establishing apical cortical domains
... embryonic development in mammals, epithelial cysts serve as progenitors for the morphogenesis of more complex organs, for example, blastocysts, somites, cysts of epicardial progenitor (EPP) cells and renal ...
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Temporal requirement for hedgehog signaling in ventral telencephalic patterning
... the development of the mature mammalian CNS from its beginnings as a simple ...neural development has been studied in the developing mammalian spinal cord, and it is now clear that Hh proteins are an ...
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Rac1 and Rac3 GTPases Control Synergistically the Development of Cortical and Hippocampal GABAergic Interneurons
... Tangential migration occurs via the cortical IZ and MZ for early-born neurons (E11.5 – E14.5) and via the cortical SVZ for those born at E14.5 – E16.5 (Anderson et al. 2001; Hernández- Miranda et al. 2010). ...
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