Cortical Spreading Depression
Cortical spreading depression activates and upregulates MMP 9
... USA. Cortical spreading depression (CSD) is a propagating wave of neuronal and glial depolarization and has been implicated in disorders of neurovascular regulation such as stroke, head trauma, and ...
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In vivo imaging reveals that pregabalin inhibits cortical spreading depression and
... 2 Abstract Migraine is characterized by severe headaches that can be preceded by an aura likely caused by cortical spreading depression (SD). The anti-epileptic pregabalin (Lyrica) shows clinical ...
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ROS/TRPA1/CGRP signaling mediates cortical spreading depression
... understood. Cortical spreading depression (CSD) is a key patho- physiological basis of migraine aura [1 – ...suppresses cortical susceptibility to CSD [5, ...
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Synergistic Suppression of Cortical Spreading Depression under NR2A and NR2B Inhibition
... Abstract Cortical spreading depression (CSD) is a transient synaptic excitation, followed by depression, which can propagate slowly across cortex, subcortex and ...
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Effects of cathodal transcranial direct current stimulation on cortical spreading depression
... induce cortical spreading ...trigger spreading depressions, the most popular of which is the application of potassium chloride (KCl) onto the cortical ...
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Refractory Period Modulates the Spatiotemporal Evolution of Cortical Spreading Depression: A Computational Study
... Abstract Cortical spreading depression (CSD) is a pathophysiological phenomenon, which underlies some neurological disorders, such as migraine and stroke, but its mechanisms are still not completely ...
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Cortical spreading depression produces a neuroprotective effect activating mitochondrial uncoupling protein-5
... Keywords: cortical spreading depression, neuroprotective effect, uncoupling protein-5 Introduction Cortical spreading depression (CSD) consists of an electrocorticogram (ECoG) ...
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Electrophysiological analysis of transcranial direct current stimulation and its effect on cortical spreading depression
... Cortical Spreading Depression Cortical spreading depolarization (CoSD), first described by Aristides Leão in 1944, refers to a specific response that has been observed in neurons ...
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Cortical Spreading Depression Causes Unique Dysregulation of Inflammatory Pathways in a Transgenic Mouse Model of Migraine
... to cortical spreading depression (CSD), the mechanism underly- ing migraine ...isolated cortical tissue of FHM1 R192Q mice 24 h after experimentally induced CSD in order to identify molecular ...
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Changes in Extracellular Space Volume and Geometry Induced by Cortical Spreading Depression in Immature and Adult Rats
... Key words Cell swelling • Cortex • Diffusion • Spreading depression • Extracellular space Introduction Cortical spreading depression (SD) (Leão 1944, Bureš et al. 1974), implicated in ...
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Protection of flunarizine on cerebral mitochondria injury induced by cortical spreading depression under hypoxic conditions
... Cortical spreading depression (CSD) is a self-propagating wave of cellular depolarization that has been implicated in migraine and in progressive neuronal injury after stroke and head ...the ...
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Nitroglycerin enhances the propagation of cortical spreading depression: comparative studies with sumatriptan and novel kynurenic acid analogues
... Dovepress Knapp et al pathomechanism of migraine has been a focus for decades, these have not yet been fully elucidated. Therefore, animal experiments are essential for further investigation of the pathophysiological ...
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Unexpected effects of peripherally administered kynurenic acid on cortical spreading depression and related blood–brain barrier permeability
... Figure 2 Fluorescence intensity changes caused by plasma extravasation in the three groups. Notes: Each dot represents a mean intensity ratio (± standard error of the mean) of ten pictures, which were taken from the two ...
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Cortical spreading depression as a target for anti-migraine agents
... Recent electrophysiological data has provided direct evi- dence that CSD is a powerful endogenous process which can lead to persistent activation of nociceptors innervat- ing the meninges. Regardless of the method of ...
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Sumatriptan-Induced Sensitization of the Trigeminal System to Cortical Spreading Depression (CSD) is Blocked by Topiramate
... 64 Figure 3.11 Pretreatment of topiramate (80 mg/kg, i.p.) attenuates c-Fos expression in both saline and sumatriptan exposed rats in TNC following bright light exposure ....[r] ...
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The Neuroprotective Effects of Long-Term Repetitive Transcranial Magnetic Stimulation on the Cortical Spreading Depression-induced Damages in Rat’s Brain
... In addition, effects of CSD phenomenon in cerebrovas- cular diseases, head injury, and transient global amnesia have been reported (Gorji, 2001). Occurrence of CSD is observed in various cerebrovascular diseases ...
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Activity dependence of spreading depression in the locust CNS
... and Guedes, R. C. A. (2014). Increased calcium influx triggers and accelerates cortical spreading depression in vivo in male adult rats. Neurosci. Lett. 558, 87-90. von Bornsta ̈ dt, D., Houben, T., ...
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SIMPLIFIED REACTION-DIFFUSION EQUATIONS FOR POTASSIUM AND CALCIUM ION CONCENTRATIONS DURING SPREADING CORTICAL DEPRESSION
... The first model successfully predicts the behavior of the original reaction-diffusion system (and the potassium and calcium ion concentrations as in spreading depression)[r] ...
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Spreading depression as a preclinical model of migraine
... diminished cortical activity spreading across visual ...posterior cortical brain regions highly suggestive of SD as a neurobiological phenomenon responsible for these aura ...
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Electromagnetic interventions as a therapeutic approach to spreading depression
... greatest depression in SD velocity was accomplished using repetitive ES ...reducing cortical activity as a ...basal cortical activity is not the only factor that is modulating SD velocity in ...
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