Corticobasal degeneration
Tau pathology in aged cynomolgus monkeys is progressive supranuclear palsy/corticobasal degeneration- but not Alzheimer disease-like -Ultrastructural mapping of tau by EDX-
... and corticobasal degeneration (CBD), show a distinct path- ology where 4R tau is selectively deposited [11, 12], and distribution of tau lesions is not skewed towards the ...
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Diffusion Tensor Imaging Shows Different Topographic Involvement of the Thalamus in Progressive Supranuclear Palsy and Corticobasal Degeneration
... and corticobasal degeneration (CBD), postmortem studies show different topographic involvement of the thalamus, basal ganglia, and their cortical ...
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Imaging Pathologic Correlation in Corticobasal Degeneration
... of degeneration of the subthalamic nuclei, and 4) the presence or ab- sence of a lesion in the SCWM and whether the lesion constituted primary or secondary degeneration in ...2. Corticobasal ...
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Density and spatial pattern of β-amyloid (Aβ) deposits in corticobasal degeneration
... Corticobasal degeneration (CBD) is a rare, progressive movement disorder characterized neuropathologically by wide- spread neuronal and glial pathology including tau-immunoreactive neuronal cytoplasmic ...
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Visual signs and symptoms of corticobasal degeneration
... Corticobasal degeneration is a rare, progressive neurodegenerative disease and a member of the ‘parkinsonian’ group of disorders which also includes Parkinson’s disease, progressive supranuclear palsy, ...
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Loss of insight in frontotemporal dementia, corticobasal degeneration and progressive supranuclear palsy
... Loss of insight is one of the core features of frontal/behavioural variant frontotemporal dementia (FTD). FTD shares many clinical and pathological features with corticobasal degeneration (CBD) and ...
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Autophagic and lysosomal defects in human tauopathies: analysis of post-mortem brain from patients with familial Alzheimer disease, corticobasal degeneration and progressive supranuclear palsy
... Abnormal intracellular aggregation and accumulation of the microtubule-associated protein tau is a common fea- ture of many neurodegenerative disorders, including Alzheimer disease (AD), frontotemporal lobar degener- ...
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Dyspraxia in a patient with corticobasal degeneration: the role of visual and tactile inputs to action
... Ideational and ideomotor dyspraxia have been diVerentiated in several ways.2 For example, ideational dyspraxia has been defined by some workers as an impairment in production of transiti[r] ...
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Ultrastructural differences in pretangles between Alzheimer disease and corticobasal degeneration revealed by comparative light and electron microscopy
... IHC, immunohistochemistry; LM, light microscopy; EM, electron microscopy; PHF, paired helical filaments; *1, Density of straight tau filament is more sparse in AD-pretangles than in CBD-[r] ...
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Evaluation of Cortical Atrophy between Progressive Supranuclear Palsy and Corticobasal Degeneration by Hemispheric Surface Display of MR Images
... Progressive supranuclear palsy (PSP) and cortico- basal degeneration (CBD) are neurodegenerative dis- orders that manifest with dementia and parkinsonism in middle-aged and elderly patients. The neurologic ...
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MRI Planimetry and Magnetic Resonance Parkinsonism Index in the Differential Diagnosis of Patients with Parkinsonism
... MATERIALS AND METHODS: Fifty-two patients with Parkinson-plus (progressive supranuclear palsy, n ⫽ 24; corticobasal degeneration, n ⫽ 9; multiple system atrophy, n ⫽ 19), 18 patients with Parkinson disease, ...
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Prognostic importance of apathy in syndromes associated with frontotemporal lobar degeneration
... approximately 60% have corticobasal degeneration. 39 How- ever, with the possible exception of logopenic PPA, those with a misdiagnosis often have another FTLD pathology, further emphasizing the benefits of ...
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Alpha-synuclein and tau: teammates in neurodegeneration?
... AD: Alzheimer ’ s disease; ALS: Amyotrophic lateral sclerosis; α syn: Alpha-synuclein protein; DLB: Dementia with Lewy bodies; CBD: Corticobasal degeneration; FRET: Förster resonance ene[r] ...
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The predictive value of transcranial duplex sonography for the clinical diagnosis in undiagnosed parkinsonian syndromes: comparison with SPECT scans
... CBD: corticobasal degeneration; DIP: drug induced par- kinsonism; DLBD: diffuse Lewy body disease; ET: essen- tial tremor; FP-CIT: 123I-Ioflupane; IPD: idiopathic Parkinson's disease; IBZM: ...
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High occurrence of transportation and logistics occupations among vascular dementia patients: an observational study
... AD: Alzheimer ’ s disease; VaD: Vascular dementia; FTD: Frontotemporal dementia; DLB: Lewy body disease; PSP: Progressive supranuclear palsy; CBD: Corticobasal degeneration; ADC: Amsterd[r] ...
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On the 'classification' of neurodegenerative disorders:discrete entities, overlap or continuum?
... Originally, the majority of neurodegenerative dis- orders were classified into two major molecular groups, viz., the tauopathies: AD, PiD, argyrophilic grain disease (AGD) [123], PSP, corticobasal ...
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Trigeminal neuralgia due to pontine infarction
... and corticobasal degeneration ...lobar degeneration, corticobasal degeneration (CBD), and progressive supranuclear palsy (PSP) have overlapping clinical fea- ...
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<p>Challenges and Opportunities in Atypical Parkinsonian Syndromes: Call to Action</p>
... Neurodegenerative diseases in fl ict a substantial burden on patients, caregivers, and the healthcare system as a whole. Already a leading cause of disability and death in the United States, the impact of these diseases ...
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Retinal thickness as potential biomarker in posterior cortical atrophy and typical Alzheimer’s disease
... macular degeneration; CBD: Corticobasal degeneration; CSF: Cerebrospinal fluid; DLB: Dementia with Lewy bodies; EOAD: Early-onset Alzheimer ’ s disease; ETDRS: Early treatment Diabetic retinopathy ...
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Early-onset dementias: diagnostic and etiological considerations
... example, corticobasal degeneration (CBD), Pick’s disease, PSP), non-Tau patho- logies (for example, FTLD-TDP) and mixed amyloid and Tau pathology (for example, AD), making it more pathologically ...
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