COX-2 inhibitors
Cyclooxygenase-2 (COX-2) inhibitors: future therapeutic strategies for epilepsy management
... to COX-2 ex- pression may involve regulatory kinases such as SPK, TK, PKC, NF-κB, ERK, and MAPK [58, ...induced COX-2 via ERK, thus mediating astroglial- neuronal interaction to enhance ...
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A Regression Model using K Means Algorithm to Screen 32 Compound Dataset as COX 2 Inhibitors
... A modified k-means clustering analysis was implemented in the study.k-means clustering is an iterative clustering procedure works as a greedy algorithm for partitioning the n samples into k clusters and predefines the ...
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Efficacy and safety of COX-2 inhibitors for advanced non-small-cell lung cancer with chemotherapy: a meta-analysis
... favoring COX-2 inhibitors plus chemotherapy over chemotherapy alone, was observed in the overall response rate (relative risk [RR] ...of COX-2 inhibitors (celecoxib, rofecoxib, ...
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Discovering COX-2 Inhibitors from Flavonoids and Diterpenoids
... against COX enzymes for anti- inflammatory discovery using molecular docking ...both COX binding ...Selective COX-2 inhibitors, respectively, are (1) 3,19-O-diacetylandrographolide; ...
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2D QSAR STUDY OF INDOLE DERIVATIVES AS SELECTIVE COX 2 INHIBITORS
... of indole nucleus and other structural features of different COX-2 inhibitors (pyrazoline derivatives, pyrimidine derivatives, and sulfinyl methyl group) in the designed molecules. Thus, the concept ...
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Reduction in cancer risk by selective and nonselective cyclooxygenase-2 (COX-2) inhibitors
... (COX-2) inhibitors (coxibs) against cancers of the breast, colon, prostate, and ...least 2 years was associated with risk reductions of 71%, 70%, 55%, and 60% for breast cancer, colon cancer, ...
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A double prodrug system for colon targeting of benzenesulfonamide COX 2 inhibitors
... benzenesulfonamide COX-2 inhibitors provided that: (i) the required acylation of the sulfonamido group could be accomplished synthetically, and; (ii) intramolecular aminolysis of acylsulfonamide ...
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Cardiovascular and gastrointestinal effects of COX 2 inhibitors and NSAIDs: achieving a balance
... pump inhibitors (PPIs), and the introduction of the selective COX-2 inhibitors ...both COX-1 and COX-2 isoenzymes involved in prostaglandin synthesis ...[4]. COX-1 ...
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Practical approaches to minimizing gastrointestinal and cardiovascular safety concerns with COX 2 inhibitors and NSAIDs
... of COX-2 inhibitors or NSAIDs plus a PPI are equally effective in reducing the risk for ulcer ...a COX-2 inhibitor or an NSAID with PPI ...prophylaxis, COX-2 ...
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Should selective Cox-2 inhibitors be used more?
... The unanticipated outcomes of several clinical studies raised a number of issues regarding the clinical efficacy and overall safety of selective coxibs. The important issue that has to be resolved is that the ...
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Prescription channeling of COX 2 inhibitors and traditional nonselective nonsteroidal anti inflammatory drugs: a population based case–control study
... of COX-2 ...a COX-2 inhibitor than a traditional nonselective ...with COX-2 inhibitors in patients without risk factors, and under-treatment in patients who had at least ...
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IN SILICO DESIGN AND MOLECULAR DOCKING STUDIES OF NOVEL PYRIDYL TRIAZOLE DERIVATIVES AS COX-2 INHIBITORS
... selective COX-2 inhibitors based on docking studies and oral bioavailability scores based on Lipinski’s rule ...of COX -2 enzyme (pdb code: ...against COX -2 with a ...
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Exploring Structural Parameters for Designing Cox 1 and Cox 2 Inhibitors: Pharmacophoric Modeling, Virtual Screening and Docking Study
... forms COX-1 and COX-2 [2]. COX-1 isoenzyme produced PGs which exerts effects like gastric mucosal defense and renal homeostasis, whereas COX-2 synthesizes harmful PGs ...
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QSAR Study of 4-Benzylideneamino-Benzenesulfonamides and 4-Phenyliminomethyl-Benzenesulfonamides as Selective Cox-1 and Cox-2 Inhibitors
... the COX-2 selective inhibitor NSAID drugs were thought to be a major breakthrough, with the Expectation of a significant reduction in gastrointestinal (GI) side ...effects. COX-2 is induced in ...
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Cox-2 inhibitors from stem bark of Bauhinia rufescens lam. (Fabaceae)
... cyanomethylenecyclohexylglucoside (4) and seqouyitol (5) compounds isolated from Simmondsia chinensis (Van Boven et al., 1994) and Ceratonia siliqua (Baumgartner et al., 1986, Binder and Haddon, 1984) re- spectively. The ...
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Enhancement of intestinal absorption of few cox-2 inhibitors through interaction with ?-cyclodextrin
... Drug dissolution from all the formulations followed first order kinetics as a straight line was obtained when log of drug remaining plotted against time. The corresponding dissolution efficiencies i.e., DE 30 % ...
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Combination therapy of PKCζ and COX-2 inhibitors synergistically suppress melanoma metastasis
... C57BL/6 mice, 5–6 weeks old, were purchased from the Food and Drug Verification Institute (Beijing, China). All animal experiments were approved by the Animal Ethics Committee of Tianjin Medical University and complied ...
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Design and Synthesis of Novel Indolizine Analogues as COX-2 Inhibitors: Computational Perspective and in vitro Screening
... vitro COX-2 inhibitory activity of indolizine analogs with selective (Celecoxib) and non- selective (Indomethacin) standard compounds were carried out using one-way investigation of variance (ANOVA) that ...
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Design, Synthesis and biological evaluation of some novel indole derivatives as selective COX-2 inhibitors
... Adult male Wister albino rats (120-150 g) were obtained from the animal house, (Nahda University, Beni-Suef, Egypt) were used throughout the study and were kept at controlled conditions (temperature 27 ± 2 °C, ...
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Synthesis, Biological Evaluation, and Docking Analysis of Methyl Hydroquinone and Bromo Methyl Hydroquinone as Potent Cyclooxygenase (COX-1 and COX-2) Inhibitors
... ovine COX-1 and human recombinant COX-2 (IC50 value, mM) enzymes were determined by measuring prostaglandin F2a (PGF2a) using a COX Inhibitor Screening Kit (Catalog No 560131) from Cayman ...
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