COX-2/PGE2 production
Original Article HGF/MET signaling promotes glioma growth via up-regulation of Cox-2 expression and PGE2 production
... promote PGE2 production in glioma cells via Cox-2 ...for Cox-2 up-regulation. Moreover, HGF could enhance Cox-2 expression and PGE2 ...of Cox-2 ...
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WWL70 attenuates PGE2 production derived from 2-arachidonoylglycerol in microglia by ABHD6-independent mechanism
... CCAAG-3′; COX-2 forward, 5′-GAAATGGCTGCAGAA TTGAA-3′, reverse, 5′-AAGGAGAATGGTGCTCCAAG- 3′; ABHD6 forward, 5′-CATTCCAATCCTGGCATTTG TTG-3′, reverse, 5′-ATGGTGTGCGTAGCGAACTT-3′; and GAPDH forward, 5 ′ ...
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Ethyl acetate fraction from Angelica sinensis inhibits IL-1β-induced rheumatoid synovial fibroblast proliferation and COX-2, PGE2, and MMPs production
... the production of inflammatory mediators alleviates acute inflammatory hazards and protect mice from endotoxic shock ...MMPs, COX-2, and PGE2 by RASFs and the mechanisms, which play a crucial ...
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Ethanol extract of Scutellaria baicalensis Georgi prevents oxidative damage and neuroinflammation and memorial impairments in artificial senescense mice
... and PGE2 production were also ...and Cox-2 levels were increased and SBG downregulated the expression of COX-2 and iNOS ...the Cox-2 and iNOS ...and PGE2 ...
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Superinduction of cyclooxygenase 2 activity in human osteoarthritis affected cartilage Influence of nitric oxide
... released PGE2 at 48 h in ex vivo culture at levels at least 50-fold higher than in normal cartilage and 18-fold higher than in normal cartilage + cytokines + ...of PGE2 production coincides with the ...
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Rheumatoid arthritis synovial fibroblasts promote TREM 1 expression in monocytes via COX 2/PGE2 pathway
... the production of many che- mokines such as MCP-1 and IL-8 and inflammatory cytokines TNF-a, IL-1β, and IL-12, degranulation of neutrophils, phagocytosis [11, 12], polarization of mac- rophages [14], activation of ...
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Hippocampal CA1 βCaMKII mediates neuroinflammatory responses via COX-2/PGE2 signaling pathways in depression
... prompts COX-2 tran- scription and expression. The upregulation of COX-2 may augment the production of its downstream mol- ecule, PGE2, in CA1 ...
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Norepinephrine enhances the LPS-induced expression of COX-2 and secretion of PGE2 in primary rat microglia
... increases COX-2 mRNA and protein expression at 4 and 8 h, respectively ...of COX-2 mRNA and protein ...increased production of MMP-1 and ...
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Areca nut components stimulate ADAM17, IL-1 , PGE2 and 8-isoprostane production in oral keratinocyte: role of reactive oxygen species, EGF and JAK signaling
... induce COX-2 expression/PGE 2 production in GK ...PGE 2 , indicating the presence of crosstalk between EGFR and arachidonic acid metabolism ...of COX-2 and EGFR in oral ...
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The role of bile acids in cellular invasiveness of gastric cancer
... Background: Bile acids have been implicated in the development of digestive tract malignancy by epidemiological, clinical and animal studies. The growth and transformation signaling by most of the bile acids is thought ...
8
Formononetin inhibits enterovirus 71 replication by regulating COX 2/PGE2 expression
... In the present study, we found that formononetin could inhibit the EV71-induced CPE in Vero or SK-N- SH cells. Formononetin could also inhibit viral RNA and protein synthesis in a dose-dependent manner. Time course assay ...
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Original Article Diosgenin inhibits IL-1β-induced expression of inflammatory mediators in human osteoarthritis chondrocytes
... Abstract: It is well known that the inflammatory cytokines play important roles in osteoarthritis (OA). Diosgenin is a steroidal saponin found in several plants including Solanum and Dioscorea species and possesses ...
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mTOR inhibition improves the immunomodulatory properties of human bone marrow mesenchymal stem cells by inducing COX-2 and PGE2
... or COX-2 of MSCs, short hairpin (sh)RNAs were constructed into the pGLV2-U6- Puro lentiviral vector ...virus production, shRNA constructs were cotransfected with psPAX2 and ...
13
Activation of COX-2/PGE2 Promotes Sapovirus Replication via the Inhibition of Nitric Oxide Production
... D iarrhea is the second greatest cause of mortality in children worldwide (1). Viruses within the genera Norovirus and Sapovirus in the family Caliciviridae are significant causes of gastroenteritis in humans and animals, ...
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Arachidonic acid in Alzheimer's disease
... Therefore, other approaches are needed to explain the discrepancy between the data of the observational studies or the works on AD animal models on one hand and those of the clinical trials on the other hand. Parallel ...
6
Original Article Chlorogenic acid suppresses interleukin-1β-induced inflammatory mediators in human chondrocytes
... NO production via Figure 2. Effects of CGA on iNOS and COX-2 gene expression in IL-1β-induced ...and COX-2 was detected by quantitative real-time ...
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Original Article Allicin reduces IL-1β-induced inflammatory cytokines via attenuating the NF-κB and MMP3 activation in human osteoarthritis chondrocytes model
... PGE 2 and NO production in the IL-1β treatment were determined via using the ELISA and Griess ...and COX-2 expression in dose dependent man- ...PGE 2 , NO and collagenase-3 (MMP-13) ...
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Supplement of 5 hydroxytryptophan before induction suppresses inflammation and collagen induced arthritis
... 5-HTP is indicated for depression, obesity, headaches, fibromyalgia and insomnia. Administration of 5-HTP re- sults in nausea, diarrhea, and vomiting in some patients; nevertheless, these side effects are mild and there ...
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In situ microdialysis in bone tissue Stimulation of prostaglandin E2 release by weight bearing mechanical loading
... a 2-mm hole (depth z 50 mm) was drilled in the ...diameter 2 mm, was then in- troduced in the cortical part of the metaphysis to protect the catheter from cortical swelling and to minimize ...
5
Effect of COX-2 inhibition on tendon-to-bone healing and PGE2 concentration after anterior cruciate ligament reconstruction
... density, PGE2 concentration of the synovial fluid, maximal load to fail- ure or stiffness of the tendon graft were each ascertained according to the Spearman-Rho correlation ...
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