COX inhibitor
Cyclooxygenase 1–selective inhibition prolongs gestation in mice without adverse effects on the ductus arteriosus
... or COX) inhibitors, also known as nonsteroidal anti-inflammatory drugs (NSAIDs), rep- resent one of the several classes of tocolytics effective for delaying labor in the short term, but their useful- ness is ...
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Angiotensin II attenuates renal cortical cyclooxygenase 2 expression
... production, COX inhibition may have profound consequences for renal ...of COX activity ...3). COX inhibitors suppress plasma renin (4–7), and intrarenal infusion of arachidonic acid stimulates renin ...
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The quest for targeted delivery in colon cancer: mucoadhesive valdecoxib microspheres
... the COX-1 and COX-2 forms of the enzyme cyclo-oxygenase ...The COX-1 enzyme is required for physiological processes such as maintenance of gastrointestinal mucosa and platelet ...enzyme COX-2 ...
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Activity and potential role of licofelone in the management of osteoarthritis
... of COX-1 (constitutive isoform), whereas the benefi cial effects are related to the inhibition of COX-2 (inducible ...competitive inhibitor, decreases the production of proinfl ammatory leukotrienes ...
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Cyclooxygenase Inhibitors Affect Recovery of Ischemic-injured Jejunum
... that COX-1 is responsible for normal physiologic function whereas COX-2 is proinflammatory, so-called ‘GI-safe’ NSAIDs have been developed that selectively inhibit ...inhibit COX isoforms to some ...
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Association of maternal pancreatic function and foetal growth in rats treated with DFU, a selective cyclooxygenase-2 inhibitor
... studies COX-1 immunoexpression in the pancreas has been limited to acinar secretory cells, while COX-2 was found in secretory cells of the endo- crine pancreatic islets and in epithelial cells of the ...
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Microarray analysis of NSAIDs-treated cardiomyocytes to search for genes involved in COX-2 inhibitor cardiotoxicity
... Nonspecific COX inhibitors can cause gastric and renal toxicity, attributed to the inhibition of COX-1- derived prostaglandins (Wolfe et ...Selective COX-2 inhibitors, such as diclofenac and ...
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Significant Combination of Preferential COX-2 Inhibitor and Non-Anticholinergic Spasmolytic Used In Labor Augmentation
... Adverse effects of the Non-selective cox inhibitor NSAIDs are usually dose related, although many dose unrelated effects like idiosyncratic effects also appear. These include urticarial rashes, angioedema ...
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Effect of cyclooxygenase inhibition on cholesterol efflux proteins and atheromatous foam cell transformation in THP 1 human macrophages: a possible mechanism for increased cardiovascular risk
... on COX-2 expression in macrophages, exogenous administration of COX inhibitors may exacerbate macrophage ...of COX inhibition could create a micro- environment within the vessel wall where ...
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The effect of non-steroidal anti-inflammatory drugs on the osteogenic activity in osseointegration: a systematic review
... of COX enzymes promotes bone formation and resorption through the production of PGs {Evans, 2004 ...of COX-1 equally, if not more than COX-2 {Boursinos, 2009 ...that COX-2 inhibitors delay ...
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Decreased susceptibility to renovascular hypertension in mice lacking the prostaglandin I2 receptor IP
... of COX inhibitors in renovascular hypertension, although the results are ...of COX-2 inhibitors on BP in renovascular hypertension (12, ...of COX-2 inhibitors on a variety of systemic actions of the ...
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Effect of regulated expression of human cyclooxygenase isoforms on eicosanoid and isoeicosanoid production in inflammation
... to COX-1 were confirmed using a rabbit polyclonal antibody raised against the same protein (ram-purified ...for COX-1 as described previ- ously (37) and confirmed by us in COS-7 cells stably transfected ...
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ANTI INFLAMMATORY AND ANTIPYRETIC ACTIVITY OF SELECTIVE COX 2 INHIBITOR WITH CONVENTIONAL NSAIDs
... selective COX- 2 inhibitor has high cardiovascular side effects, with low GI side effects, as compare to the conventional NSAID and it is proved that low dose of any drugs is always good for the health due ...
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YAP transcriptionally regulates COX-2 expression and GCCSysm-4 (G-4), a dual YAP/COX-2 inhibitor, overcomes drug resistance in colorectal cancer
... direct COX-2 inhibition independent of its suppression on ...dual inhibitor of YAP and COX-2. Because YAP and COX-2 are involved in drug resistance, we further discovered that their downstream ...
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Inhibition of cyclooxygenase 2 in hematopoietic cells results in salt sensitive hypertension
... which COX-2 inhibition leads to devel- opment or exacerbation of hypertension has been attributed to inhibition of intrinsic renal COX-2 activity, which leads to increased sodium retention by the kidney ...
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Acetylsalicylic acid supplementation improves protein utilization efficiency while vitamin E supplementation reduces markers of the inflammatory response in weaned pigs challenged with enterotoxigenic E. coli
... Data were analyzed by two-way ANOVA using the pig as the experimental unit. The main and interactive effects of the supplemental Vit E and ASA were included as fixed factors in the statistical model. As there was a ...
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The Role of Beta-Adrenergic Receptor Blockers in Autism
... In addition, the administration of propranolol and a COX-2 inhibitor, which can be applied peri-operatively in most cancer patients with minimal risk and low cost, count[r] ...
8
Nitric oxide amplifies interleukin 1 induced cyclooxygenase 2 expression in rat mesangial cells
... for COX-2, the inducible isoform of COX; however, they both potenti- ated IL-1 b –induced mRNA and protein expression of ...an inhibitor of the soluble guanylate cyclase, methylene blue, reversed the ...
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Palbociclib inhibits epithelial-mesenchymal transition and metastasis in breast cancer via c-Jun/COX-2 signaling pathway
... protease Inhibitor (Selleck, Houston, TX, USA) and 1% phosphotransferase inhibitor was used to lyse ...Snail, COX-2, p38, ERK, p-ERK, JNK, c-Jun, p-c-Jun and histone H3 were obtained from Cell ...
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Crypt stem cell survival in the mouse intestinal epithelium is regulated by prostaglandins synthesized through cyclooxygenase 1
... that Cox-1 and Cox-2 make different contributions to eicosanoid production in different cell types, and also make different contributions to eicosanoid produc- tion in the same cell type under different ...
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