Coxsackievirus B3
Emergence of a Large Plaque Variant in Mice Infected with Coxsackievirus B3
... ABSTRACT Coxsackieviruses are enteric viruses that frequently infect humans. To examine coxsackievirus pathogenesis, we orally inoculated mice with the coxsackievirus B3 (CVB3) Nancy strain. Using ...
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Human Astrocytic Cells Support Persistent Coxsackievirus B3 Infection
... ductive coxsackievirus B3 (CVB3) infection, an outcome not previously demonstrated for CVB3 infection in human brain ...receptors coxsackievirus-adenovirus receptor (CAR) and decay-accelerating ...
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RT-PCR Detection of Coxsackievirus B3: A Viral Myocarditis
... of coxsackievirus B3 RNA in animal models, viral infected-HeLa cells, and myocardial biopsy samples from patients with myocarditis and dilated cardiomyopathy via the RT- ...the coxsackievirus ...
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Interleukin 27 ameliorates coxsackievirus B3 induced viral myocarditis by inhibiting Th17 cells
... in coxsackievirus B3 (CVB3)-induced myocarditis mice peaked on day 4 but then rapidly decreased during the late infectious stage of CVB3, high IL-27 levels were negatively correlated with bodyweight loss ( ...
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Tyrosine phosphorylation events during coxsackievirus B3 replication.
... In order to study cellular and viral determinants of pathogenicity, interactions between coxsackievirus B3 (CVB3) replication and cellular protein tyrosine phosphorylation were investigated. During CVB3 ...
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The role of CD8+ T lymphocytes in coxsackievirus B3-induced myocarditis.
... processes in pathogenesis, we have compared coxsackievirus B3 (CVB3) infections of normal and immuno- compromised transgenic knockout (ko) mice. CVB3 was able to infect all strains used (C57BL/6, CD4ko, and ...
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Autophagosome Supports Coxsackievirus B3 Replication in Host Cells
... in coxsackievirus replication. Coxsackievirus B3 (CVB3), a picornavirus associated with viral myocarditis, causes pronounced intracellular membrane reorganization after ...
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Roles of Tumor Necrosis Factor Alpha (TNF-α) and the p55 TNF Receptor in CD1d Induction and Coxsackievirus B3-Induced Myocarditis
... promotes coxsackievirus B3 (CVB3)-induced myocarditis in otherwise disease-resistant mice (21, 22, 25), while neutraliza- tion of endogenous TNF- ␣ protects against myosin-induced myocarditis ...
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Coxsackievirus B3-Induced Cellular Protrusions: Structural Characteristics and Functional Competence
... Virus-induced alterations in cell morphology play important roles in the viral life cycle. To examine the intracellular events of coxsackievirus B3 (CVB3) infection, green monkey kidney (GMK) cells were ...
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Requirements for RNA Replication of a Poliovirus Replicon by Coxsackievirus B3 RNA Polymerase
... Poliovirus type 1 (PV1), the prototypic member of the pi- cornavirus family, belongs to the genus Enteroviridae, as does coxsackievirus B3 (CVB3). CVB3 is closely related to PV1 with respect to its ...
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Amiloride Derivatives Inhibit Coxsackievirus B3 RNA Replication
... Amiloride derivatives are known blockers of the cellular Na ⴙ /H ⴙ exchanger and the epithelial Na ⴙ channel. More recent studies demonstrate that they also inhibit ion channels formed by a number of viral proteins. We ...
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Valproic acid ameliorates coxsackievirus B3 induced viral myocarditis by modulating Th17/Treg imbalance
... Valproic acid ameliorates coxsackievirus B3 induced viral myocarditis by modulating Th17/Treg imbalance RESEARCH Open Access Valproic acid ameliorates coxsackievirus B3 induced viral myocarditis by mo[.] ...
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Specific Alterations of Coxsackievirus B3 Eluted from Hela Cells
... The findings that eluted coxsackievirus B3 had a lighter buoyant density in a potassium tartrate gradient and that it sedimented more slowly in sucrose gradients than normal B3 virus are[r] ...
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The Coxsackievirus and Adenovirus Receptor: Glycosylation and the Extracellular D2 Domain Are Not Required for Coxsackievirus B3 Infection
... C oxsackie B viruses (CVBs) initiate infection of their host cells by interaction with the coxsackievirus and adenovirus recep- tor (CAR). An additional cell surface protein, decay-accelerating factor (DAF), ...
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Altered receptor specificity of coxsackievirus B3 after growth in rhabdomyosarcoma cells.
... 5A indicated that expomultiplicity of 1,000 PFU per cell before attachment of the CB3 sure of HeLa cells to high levels of CB1 blocked the parent 0, CB3-RD 0, and PT2 x; B cells preincub[r] ...
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Characterization and myocarditic capabilities of coxsackievirus B3 variants in selected mouse strains.
... Importance of gender on the induction of myocarditis by CVB3m, or tslOR variants in different strains of mice' Virus contents and extent of myocarditis in mice inoculated with: Mouse str[r] ...
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Oncolytic activity of a coxsackievirus B3 strain in human endometrial cancer cell lines
... CV-B3 2035A strain was isolated from a throat swab of an HFMD patient in Xiamen, China in 2008. A phylogenetic tree was constructed for CV-B3/2035A and 42 other CV- B3 strains based on the whole ...
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Dysregulation of the Ubiquitin-Proteasome System by Curcumin Suppresses Coxsackievirus B3 Replication
... In the present study, we have provided evidence that curcu- min is a novel inhibitor of CVB3 replication. We showed that curcumin strongly reduces viral-RNA expression, protein syn- thesis, and virus titer but does not ...
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Kinetic and Structural Analysis of Coxsackievirus B3 Receptor Interactions and Formation of the A-Particle
... The coxsackievirus and adenovirus receptor (CAR) has been identified as the cellular receptor for group B coxsackieviruses, in- cluding serotype 3 (CVB3). CAR mediates infection by binding to CVB3 and catalyzing ...
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Variations of Coxsackievirus B3 Capsid Primary Structure, Ligands, and Stability Are Selected for in a Coxsackievirus and Adenovirus Receptor-Limited Environment
... the coxsackievirus and adenovirus receptor (CAR) as the receptor through which they infect susceptible cells, some CVB strains are known for their acquired capacity to bind other ...
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