CpG dinucleotides
Mutations of CpG dinucleotides located in the triiodothyronine (T3) binding domain of the thyroid hormone receptor (TR) beta gene that appears to be devoid of natural mutations may not be detected because they are unlikely to produce the clinical phenotype of resistance to thyroid hormone
... of CpG dinucleotides located in the triiodothyronine (T3)-binding domain of the thyroid hormone receptor (TR) beta gene that appears to be devoid of natural mutations may not be detected because they are ...
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Preservation of methylated CpG dinucleotides in human CpG islands
... methylated CpG dinucleo- tides in human CpG islands” by ...for CpG islands, although it can no longer be viewed as null hypothesis, because we know that a lot of noncoding sequences are under selec- ...
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DNA methylation regulates mouse cardiac myofibril gene expression during heart development
... ssTnI CpG island forwarding pri- mer: 5′-TGGGGTTAGAGTGTAAAGTTAATATTG-3′, reversing primer: 5′-TATAACTCCAAACACCCATCTC ...ssTnI CpG dinucleotides region forwarding primer: ...
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Increasing the CpG dinucleotide abundance in the HIV 1 genomic RNA inhibits viral replication
... of CpG dinucleotides in HIV‑1 and codon modification introduced a substantial increase in CpG ...introducing CpG dinucleo‑ tides were mutated back to the wild type codon, which restored ...
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Sex differences of leukocytes DNA methylation adjusted for estimated cellular proportions
... 485,764 CpG dinucleotides that covered 99 % of the RefSeq genes and were distributed across whole gene re- gions, including promoters, gene bodies, and 3′-untrans- lated regions ...the CpG islands ...
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CpG and UpA dinucleotides in both coding and non coding regions of echovirus 7 inhibit replication initiation post entry
... of CpG-high E7 virions and a measurable proportion of those with high UpA sequences to initiate replication post-entry may originate from mutational defects in their genome sequences which is possibly mediated ...
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A CpG oligodeoxynucleotide enhances the immune response to rabies vaccination in mice
... unmethylated CpG dinucleotides in particular sequence contexts (CpG ...motifs). CpG ODNs can trigger cells that express Toll-like receptor 9 (including human plasmacy- toid dendritic cells and ...
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Formulation with CpG Oligodeoxynucleotides Prevents Induction of Pulmonary Immunopathology following Priming with Formalin-Inactivated or Commercial Killed Bovine Respiratory Syncytial Virus Vaccine
... methylated CpG dinucleotides flanked by two 5 ⬘ purines and two 3 ⬘ pyrimidines (CpG motif) have been reported to have immunomodulatory activity ...receptors, CpG can activate dendritic cells ...
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Genome remodelling in a basal-like breast cancer metastasis and xenograft.pdf
... We then compared the fraction of the three classes of guanine mutations occurring at CpG dinucleotides in primary tumour, brain metastasis and xenograft and found that the frequencies of[r] ...
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A methylated oligonucleotide inhibits IGF2 expression and enhances survival in a model of hepatocellular carcinoma
... (CpG) dinucleotides, we designed a methylated oligonucleotide (MON1) complementary to a region encom- passing IGF2 promoter P4 in an attempt to induce DNA methylation at that locus and diminish IGF2 mRNA ...
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Genetic Inactivation of Poliovirus Infectivity by Increasing the Frequencies of CpG and UpA Dinucleotides within and across Synonymous Capsid Region Codons
... tween CpG and UpA, although in both instances selection appears to act primarily through genome-wide mutational pro- cesses, and only secondarily on translated sequences (4, ...most CpG dinucleotides ...
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Epigenetic silencing of the ANKRD26 gene correlates to the pro-inflammatory profile and increased cardio-metabolic risk factors in human obesity
... 92 CpG dinucleotides related to our candidate gene, whose detection, at the best of our knowledge, is only partially covered by com- mercial DNA methylation arrays and (ii) identify among lean and obese ...
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Exploring Healthcare Consumer Involvement in Clinical Practice Guideline Development
... in CPG development, a descriptions of current strategies is ...in CPG development, including authors and research advisors, also contributed information through participating in interviews or completing ...
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Epigenomic analysis of aberrantly methylated genes in colorectal cancer identifies genes commonly affected by epigenetic alterations.
... hypermethylated CpG sites, 4 CpG sites (ADHFE1, BOLL, SLC6A15, ADAMTS5) were selected because these genes were the most highly methylated in CRC compared to the normal mucosa, and 6 CpG sites (TFPI2, ...
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Selective intra-dinucleotide interactions and periodicities of bases separated by K sites: a new vision and tool for phylogeny analyses
... Lactobacillus casei, Clostridium botulinum and Myco- plasma hominis (Mollicutes) which are non-Bacillus Firmicutes. Table 8 presents the periodicities found in the most deviated (from randomness) pair (first signifi- ...
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Natural Selection Affects Frequencies of AG and GT Dinucleotides at the 5′ and 3′ Ends of Exons
... we compared observed and expected frequencies of AG ceding intron-exon junction likely contributes to selec- tion against exonic AG in the vicinity of splicing site in pairs on the inter[r] ...
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Construction and Immunological Evaluation of CpG Au@HBc Virus Like Nanoparticles as a Potential Vaccine
... designing CpG-Au@HBc VLPs ...The CpG-Au conjugates were subsequently added and co- incubated for another 20 min using slight vibrational mo- ...of CpG-Au core-containing VLPs were performed by ...
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Replication of Bacteriophage Ribonucleic Acid: Some Properties of Native and Denatured Replicative Intermediate
... According to the theoretical analysis of RI, complete denaturation should yield a population of single-stranded molecules with equal numbers of molecules from dinucleotides up to a chain[r] ...
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Double-stranded phosphodiester cytosine-guanine oligodeoxynucleotide complexed with calcium phosphate as a potent vaccine adjuvant for activating cellular and Th1-type humoral immunities
... ds CpG-B72-PD-Lipo, ds CpG-B72-PD binds to the Lipo surface via electrostatic interactions (Figure ...ds CpG-B72-PD was also located on the surface of CaP in ds CpG-B72-PD-CaP (Figure S4B), it ...
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CpG methylation in the serotonin transporter gene (SLC6A4) promoter region is not associated with age or social rank of male rhesus macaques ( Macaca mulatta)
... We have demonstrated the feasibility of a restriction enzyme digestion assay to determine methylation status in a potential SLC6A4 regulatory region. Samples treated with M.SssI, which should be 100% methylated, showed ...
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