CpG Island
CpG island methylation of TMS1/ASC and CASP8 genes in cervical cancer
... 5. Gonzalez-Gomez P, Bello MJ, Inda MM, Alonso ME, Arjona D, Aminoso C, Lopez-Marin I, de Campos JM, Sarasa JL, Castresana JS, Rey JA: 2004.Deletion and aber- rant CpG island methylation of Caspase 8 gene ...
5
Detection of promoter hypermethylation of the CpG island of E-cadherin in gastric cardiac adenocarcinoma
... Our results showed that protein expression of E- cadherin in tumor tissues significantly lower than that in paired normal tissues, however, immunohistochemi- cal staining also showed normal membranous staining of ...
6
Demonstration of potential link between Helicobacter pylori related promoter CpG island methylation and telomere shortening in human gastric mucosa
... Helicobacter pylori (H. pylori) infected gastric mucosa is characterized as chronic inflammation [11, 12], which is closely linked with telomere length shortening [13, 14]. These facts suggest that shortened telomere ...
8
CpG island composition differences are a source of gene expression noise indicative of promoter responsiveness
... for CpG islands as sources of gene expression ...among CpG island promoters can be partially attributed to differences in island size, in which short islands have noisier gene ...short ...
13
Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma.pdf
... In this report, we have identified and characterized a distinct molecular subgroup in human gliomas. Analysis of epigenetic changes from TCGA samples identified the existence of a proportion of GBM tumors with highly ...
13
Ontogeny of CpG island methylation and specificity of DNMT3 methyltransferases during embryonic development in the mouse
... many CpG islands acquire methylation slowly in late epiblast ...of CpG islands gain methylation and are found in the promoters of germline genes and in exons of important developmental ...of CpG ...
16
A reinvestigation of somatic hypermethylation at the PTEN CpG island in cancer cell lines
... There are a number of methodological strategies that can be employed to prevent the misinterpretation of data when investigating the methylation status of a gene with a pseudogene. When designing assays for a given gene, ...
8
CpG island hypermethylation-associated silencing of microRNAs promotes human endometrial cancer
... Notably, we found that 5’-Aza-CdR reversed the hypermethylation of miR-130b promoter and inhibited the maglinant behaviors of EC cells. These findings dem- onstrate that particular DNA methylation of miRNAs is associated ...
9
Methylation kinetics and CpG-island methylator phenotyope status in colorectal cancer cell lines
... A key finding from our quantitative analysis was that CIMP cells tended to start the methylation process imme- diately upon cessation of 5-AZA treatment, but did so relatively slowly, while non-CIMP cells showed a ...
14
Effects of Helicobacter Pylori Infection on Genetic Instability, The Aberrant CpG Island Methylation Status and The Cellular Phenotype in Barrett’s Esophagus in a Japanese Population
... Genetic or epigenetic alterations in Barrett’s esophagus (BE) with/without Helicobacter pylori (H. pylori) infection remain unclear. We examined the effects of H. pylori infection on genetic instability (GIN), the ...
10
Deoxyribonucleic acid methylation profiling of single human blastocysts by methylated CpG-island amplification coupled with CpG-island microarray
... We acknowledge that our pilot MCAM study is limited in that only 5 individual blastocysts were analyzed. These single-embryo hybridizations to CpG island arrays have iden- ti fi ed only the most highly ...
10
Different definitions of CpG island methylator phenotype and outcomes of colorectal cancer: a systematic review
... Our systematic literature search was performed in ac- cordance with PRISMA recommendations [11]. PubMed and ISI Web of Knowledge databases were used for the search of relevant articles from inception to 3 April 2015, ...
14
Unique characteristics of CpG island methylator phenotype (CIMP) in a Chinese population with colorectal cancer
... 48. Weisenberger DJ, Levine AJ, Long TI, Buchanan DD, Walters R, Clendenning M, Rosty C, Joshi AD, Stern MC, LeMarchand L, et al. Association of the colorectal CpG island methylator phenotype with molecular ...
10
Integrative DNA methylation and gene expression analysis to assess the universality of the CpG island methylator phenotype
... 485,000 CpG methylation levels for more than 2000 sam- ples from five tissues of origin: bladder, breast, colon, lung, and stomach (Table ...of CpG probes by CGI, including the CGI itself and its shores and ...
11
Hypermethylation of the alternative AWT1 promoter in hematological malignancies is a highly specific marker for acute myeloid leukemias despite high expression levels
... WT1 CpG island and hyper- methylated AWT1 signature was extremely prevalent in AML patients, including individuals with the recurrent ge- netic abnormalities ...
11
The overmethylated genes in Helicobacter pylori-infected gastric mucosa are demethylated in gastric cancers
... low CpG content often limit the use of an adequate MSP primer ...of CpG-island methylation, shows weak or non-specific signals when amplifying the transitional- CpG sites ...
13
The role of XPC protein deficiency in tobacco smoke induced DNA hypermethylation of tumor suppressor genes
... The methylation-enriched DNA samples were quanti- fied using a quantitative PCR (qPCR) protocol to deter- mine the DNA levels of the Brca1, Mlh1, and Xpc pro- moter region CpG island DNA sequences in each ...
9
Epigenomic dysregulation-mediated alterations of key biological pathways and tumor immune evasion are hallmarks of gingivo-buccal oral cancer
... CGI: CpG island; DMP: Differentially methylated probe; DMR: Differentially methylated region; DNMTI: DNMT inhibitor; FPKM: Fragments per kilobase of transcript per million mapped reads; GO: Gene ontology; ...
12
Time-course gene profiling and networks in demethylated retinoblastoma cell line
... of CpG island in promoter genes that are involved in biological processes, for instance apoptosis, we performed the following main integrative analysis steps: i) Gene expression profiling at 48h, 72h and ...
20
Identification of differentially methylated genes in the malignant transformation of ovarian endometriosis
... Methylated CpG island amplification coupled with representational difference analysis (MCA-RDA) was performed on 3 couples of endometriosis-associated ovarian carcinoma (EAOC) fresh samples to identify ...
7