CpG island methylator phenotype
The CpG island methylator phenotype is concordant between primary colorectal carcinoma and matched distant metastases
... 13. Shiovitz S, Bertagnolli MM, Renfro LA, Nam E, Foster NR, Dzieciatkowski S, Luo Y, Lao VV, Monnat Jr RJ, Emond MJ, et al. CpG island methylator phenotype is associated with response to ...
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Distinct features between MLH1 -methylated and unmethylated colorectal carcinomas with the CpG island methylator phenotype: implications in the serrated neoplasia pathway
... the CpG island methylator phenotype ...hypermutated phenotype, and frequent BRAF mutations, but the MLH1-non- silenced CIMP-H CRC was significantly associated with high frequencies of ...
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Original Article Nuclear maspin expression correlates with the CpG island methylator phenotype and tumor aggressiveness in colorectal cancer
... the CpG island methylator phenotype (CIMP) in ...promoter CpG island hypermethyl- ation of many tumor-related genes and is highly correlated with female gender, proximal tumor ...
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DNA methylation subgroups and the CpG island methylator phenotype in gastric cancer: a comprehensive profiling approach
... promoter CpG islands of tumor suppressor genes is an important mechanism contributing to the development of human ...the CpG Island Methylator Phenotype (CIMP) in colorectal cancer ...
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CpG Island Methylator Phenotype and Methylation of Wnt Pathway Genes Together Predict Survival in Patients with Colorectal Cancer
... CpG island methylator phenotype (CIMP) is a distinct sub- type of various cancers, characterized by an increased frequen- cy of aberrant promoter hypermethylation at specific ...these ...
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Different definitions of CpG island methylator phenotype and outcomes of colorectal cancer: a systematic review
... Contradictory results were reported for the prognostic role of CpG island methylator phenotype (CIMP) among colorectal cancer (CRC) patients. Differences in the definitions of CIMP were the ...
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Tumors with unmethylated MLH1 and the CpG island methylator phenotype are associated with a poor prognosis in stage II colorectal cancer patients
... We previously developed a novel tumor subtype classification model for duodenal adenocarcinomas based on a combination of the CpG island methylator phenotype (CIMP) and MLH1 methylation ...
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Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma.pdf
... In this report, we have identified and characterized a distinct molecular subgroup in human gliomas. Analysis of epigenetic changes from TCGA samples identified the existence of a proportion of GBM tumors with highly ...
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Pan-cancer stratification of solid human epithelial tumors and cancer cell lines reveals commonalities and tissue-specific features of the CpG island methylator phenotype
... In line with this, a number of genes have been impli- cated in CIMP outcomes in a tissue-specific manner. For example, the inactivation of mismatch repair gene MLH1 [13] correlates strongly with CIMP in colon can- cer. ...
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18q Loss of Heterozygosity in Microsatellite Stable Colorectal Cancer is Correlated with CpG Island Methylator Phenotype-negative (CIMP-0) and Inversely with CIMP-low and CIMP-high
... distinct phenotype in colorectal cancer, and tumors with CIN show frequent cytogenetic abnormalities and chromo- somal gains and losses ...promoter CpG islands of tumor suppressor genes is thought to be an ...
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Stability of the CpG island methylator phenotype during glioma progression and identification of methylated loci in secondary glioblastomas.
... The effects of tumor grade progression on the genomewide methylation of these paired samples of sGBM tumors and their earlier lower grade lesions could be assessed in the most comprehens[r] ...
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Integrative DNA methylation and gene expression analysis to assess the universality of the CpG island methylator phenotype
... Fig. 3 Gene expression variations predictive of CIMP. a Stability of each gene signature for each tissue-specific CIMP prediction as well as the “Combined-Lasso” and the “Group-Lasso” CIMP prediction task obtained and ...
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Unique characteristics of CpG island methylator phenotype (CIMP) in a Chinese population with colorectal cancer
... Due to accumulating evidence indicating that certain molecular characteristics (including CIMP, BRAF muta- tion, KRAS mutation, and MSI status) have diagnostic, therapeutic, and prognost[r] ...
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Review of the development of DNA methylation as a marker of response to neoadjuvant therapy and outcomes in rectal cancer
... (CpG) island methylator phenotype (CIMP), have been demonstrated in colorectal cancer, and their characterisation and significance are under debate, particularly in rectal ...the CpG ...
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Current applications of molecular pathology in colorectal carcinoma
... the CpG island methylator phenotype (CIMP) or serrated pathway, causes 35% of CRCs and involves epigenetic hypermethylation of CpG islands in promoter regions of tumor suppressor genes, ...
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Methylation kinetics and CpG-island methylator phenotyope status in colorectal cancer cell lines
... “methylator phenotype” implies that relevant loci in such cells become methylated ...of CpG islands in CIMP gastric cell lines compared to non-CIMP lines, mostly caused by de novo ...of CpG ...
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Deoxyribonucleic acid methylation profiling of single human blastocysts by methylated CpG-island amplification coupled with CpG-island microarray
... that CpG 121 within the neurotrimin gene (NTM) may represent a placental-speci fi c DMR that is also detectable in late preimplantation development; therefore, further investigation is required for ...
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CpG island methylation phenotype (CIMP) in oral cancer: associated with a marked inflammatory response and less aggressive tumour biology.
... the CIMP and MSI concepts in colorectal adenocarcinoma. They found that CIMP was associated with mutations of BRAF and KRAS2, older age, increased stage and poorer prognosis and showed a trend with mucinous histology. In ...
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Perisic, Tatjana (2012): Epigenetic control of GLT-1 gene activity and its modulation by psychoactive drugs in comparison to genome-wide drug effects. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... at CpG island shores than at CpG islands, and these sites are tightly linked to genes involved in developmental and regulatory processes (Doi et ...of CpG island shores in establishment ...
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CpG methylation in the serotonin transporter gene (SLC6A4) promoter region is not associated with age or social rank of male rhesus macaques ( Macaca mulatta)
... higher CpG methylation levels in a potential serotonin transporter gene regulatory region in leukocyte DNA were related to behavioral stress reactivity in infants that experienced early life ...
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