CTL, cytotoxic T lymphocyte
Identification of Dominant Optimal HLA-B60- and HLA-B61-Restricted Cytotoxic T-Lymphocyte (CTL) Epitopes: Rapid Characterization of CTL Responses by Enzyme-Linked Immunospot Assay
... (HIV-1)-specific cytotoxic T-lymphocyte (CTL) responses play a ma- jor role in the antiviral immune response, but the relative contribution of CTL responses restricted by different HLA ...
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The Memory Cytotoxic T-Lymphocyte (CTL) Response to Human Cytomegalovirus Infection Contains Individual Peptide-Specific CTL Clones That Have Undergone Extensive Expansion In Vivo
... memory CTL in a healthy virus ...the CTL response in vivo may be a factor: small changes in the amino acid composition of one peptide can change a response from being focused into being more polyclonal ...
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Impact of host immunity on HTLV 1 pathogenesis: potential of Tax targeted immunotherapy against ATL
... adult T-cell leukemia/lymphoma; AZT: azidothymidine; CR: complete remission; CTL: cytotoxic T lymphocyte; DC: dendritic cell; HAM/TSP: HTLV-1-associated myelopathy/tropical spastic ...
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Fitness Costs and Diversity of the Cytotoxic T Lymphocyte (CTL) Response Determine the Rate of CTL Escape during Acute and Chronic Phases of HIV Infection
... the T cell response ...the CTL response during viral decline accumu- lates at a relatively low rate ...⫹ T cells fol- lowing viral ...of CTL escape in the chronic phase of HIV ...
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Molecular analyses of a five-amino-acid cytotoxic T-lymphocyte (CTL) epitope: an immunodominant region which induces nonreciprocal CTL cross-reactivity.
... In contrast, the four anti-NP clones shown here mirrored the Primary anti-LCMV ARM splenic CTL and various CTL clones were incubated with H-2d targets which were either uninfected, coate[r] ...
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Mechanism of immune evasion in breast cancer
... killer; CTL, cytotoxic T lymphocyte; MHC, major histocompatibility complex; DC, dendritic cell; PD-1, programmed death receptor 1; PD-L1, PD-1 ligand; FasL, Fas ligand; Fas, factor-associated ...
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The human cytotoxic T-lymphocyte (CTL) response to cytomegalovirus is dominated by structural protein pp65: frequency, specificity, and T-cell receptor usage of pp65-specific CTL.
... the CTL responses were medi- ated by CD8 1 CTL and thus were class I restricted; in addition, comparative LDA of CD16- and CD4/CD16-depleted PBMC showed that there was no difference in the pp65-specific ...
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Feasibility study of personalized peptide vaccination for metastatic recurrent triple negative breast cancer patients
... tomography; CTL: cytotoxic T lymphocyte; ECOG: Eastern Cooperative Oncology Group; EGF-R: epidermal growth factor receptor; EZH2: enhancer of zeste homolog 2; FEC: 5- ...
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Human Memory Cytotoxic T-Lymphocyte (CTL) Responses to Hantaan Virus Infection: Identification of Virus-Specific and Cross-Reactive CD8+ CTL Epitopes on Nucleocapsid Protein
... The CTL lines that recognize the C-terminal nine amino acids of the nucleocapsid protein (421 to 429: ISNQEPLKL) are restricted by HLA A1 and are cross-reactive against several different hantavirus ...by ...
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Recent advances in the diagnosis and treatment of hemophagocytic lymphohistiocytosis
... of T cells and macrophages, leading to marked hypercyto- kinemia ...CD8+ cytotoxic T lymphocyte (CTL) cytotoxicity is one of the hallmarks of HLH and leads to impaired regulation of the ...
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Immunologic special forces: anti-pathogen cytotoxic T-lymphocyte immunotherapy following hematopoietic stem cell transplantation
... for T-cells with a T-cell receptor of known antigen specificity), or by column selection of interferon-gamma- producing T-cells following a brief stimulation with an antigen of inter- est (Figure ...
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Effective Cytotoxic T Lymphocyte Targeting of Persistent HIV 1 during Antiretroviral Therapy Requires Priming of Naive CD8+ T Cells
... absent CTL kill- ing is not a new phenomenon (63–65), nor is the expression of CD107a in the absence of IFN-␥ production (66), highlighting the possibility that a single correlate of viral control may not exist ...
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MyD88 Expression Is Required for Efficient Cross-Presentation of Viral Antigens from Infected Cells
... OVA-specific T-cell ...⫹ T cells in a MyD88-independent ...⫹ T cells. Moreover, OVA-specific cytotoxic T-lymphocyte (CTL) responses after either the transfer of ex vivo ...
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Differential Neutralization of Human Immunodeficiency Virus (HIV) Replication in Autologous CD4 T Cells by HIV-Specific Cytotoxic T Lymphocytes
... CD8 T cells is important for immunogen design, and yet most current assays do not measure the ability of responses to neutralize infectious ...(HIV)-specific cytotoxic T-lymphocyte ...
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Compensatory Mutations Restore the Replication Defects Caused by Cytotoxic T Lymphocyte Escape Mutations in Hepatitis C Virus Polymerase
... deleterious cytotoxic T lymphocyte (CTL) escape mutations in the NS5B KSKKTPMGF epitope might impair viral replication and contribute to the B57- mediated control of ...Common CTL ...
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Dynamics of a fractional order HBV infection model with capsids and CTL immune response
... Abstract. In this article, a fractional order model for hepatitis B virus (HBV) infection with capsids and immune response presented by cytotoxic T lymphocyte (CTL) cells is proposed and ...
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Virus-specific cytotoxic T-lymphocyte activity elicited by coimmunization with human immunodeficiency virus type 1 genes regulated by the bacteriophage T7 promoter and T7 RNA polymerase protein.
... of CTL priming. CTL activity at all E:T ratios from the immunized mice was detected against peptide- loaded histocompatible targets, while no activity was observed against either nonhistocompatible or ...
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Oligoclonal expansion of HIV specific cytotoxic CD8 T lymphocytes in the skin of HIV 1 infected patients with cutaneous pseudolymphoma
... 1 T lym- phocytes involving both the dermis and the epidermis has been found in HIV-1–infected patients presenting with a chronic skin ...the T cell receptor (TCR) BV-BJ junctional diversity of the ...
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In Vivo Fitness Costs of Different Gag CD8 T-Cell Escape Mutant Simian-Human Immunodeficiency Viruses for Macaques
... of cytotoxic T lymphocyte (CTL)-based vaccines for controlling human immunodeficiency virus (HIV) type 1 infection in humans and simian immunodeficiency virus (SIV) infection in macaques is ...
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Next generation sequencing analyses of the emergence and maintenance of mutations in CTL epitopes in HIV controllers with differential viremia control
... from cytotoxic T-lymphocyte (CTL) response in HIV-1 plasma ...of CTL-escape mutants in HICs reservoirs is important for understanding viremia ...of CTL-escape mutants in HICs, we ...
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