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Ctx-II

The response to oestrogen deprivation of the cartilage collagen degradation marker, CTX II, is unique compared with other markers of collagen turnover

The response to oestrogen deprivation of the cartilage collagen degradation marker, CTX II, is unique compared with other markers of collagen turnover

... the CTX-II immuno- reactivity response to oestrogen status in the upper and mar- gin zone is similar to that of urinary ...[17]. CTX-II immunoreactivity in this area was associated with ero- ...

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Relationship between CTX II and patient characteristics, patient reported outcome, muscle strength, and rehabilitation in patients with a focal cartilage lesion of the knee: a prospective exploratory cohort study of 48 patients

Relationship between CTX II and patient characteristics, patient reported outcome, muscle strength, and rehabilitation in patients with a focal cartilage lesion of the knee: a prospective exploratory cohort study of 48 patients

... higher CTX-II concen- trations compared with healthy ...in CTX-II concen- tration among patients with focal knee cartilage lesions after completing a 3 month rehabilitation ...between ...

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Combined detection of serum CTX-II and COMP concentrations in osteoarthritis model rabbits: an effective technique for early diagnosis and estimation of disease severity

Combined detection of serum CTX-II and COMP concentrations in osteoarthritis model rabbits: an effective technique for early diagnosis and estimation of disease severity

... We also found that the serum concentration of CTX-II increased over time in the OA group. The same results have been obtained in previous studies [12, 20]. These results indicate that articular cartilage ...

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The levels of urine CTX-II, C2C, and PYD in children patients with Kashin-Beck disease in Qinghai Province of China

The levels of urine CTX-II, C2C, and PYD in children patients with Kashin-Beck disease in Qinghai Province of China

... PYD derive from the breakdown of collagen. Due to its specific localization in the bones and renal excretion, the level of PYD in urine could help us better understand patho- logical changes in the bone and cartilage ...

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The urinary levels of CTX-II, C2C, PYD, and Helix-II increased among adults with KBD: a cross-sectional study

The urinary levels of CTX-II, C2C, PYD, and Helix-II increased among adults with KBD: a cross-sectional study

... and a specific marker of bone and cartilage collagen; it is more sensitive than hydroxyproline and stabilizes the collagen chain [4]. The uPYD level is a specific and sen- sitive index reflecting bone resorption [11, ...

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Tibolone inhibits bone resorption without secondary positive effects on cartilage degradation

Tibolone inhibits bone resorption without secondary positive effects on cartilage degradation

... type II (CTX-II) in serum and synovial fluid samples for estimation of articular cartilage status in experimental models of destructive joint ...

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Occupational Risk Factors for Musculoskeletal Disorders among Operation Room Nurses at Cairo University Hospitals

Occupational Risk Factors for Musculoskeletal Disorders among Operation Room Nurses at Cairo University Hospitals

... 97.8%. CTX-II in females was non-statistically significant higher than in ...of CTX-II were found in those aged ≥ 40 years than in those < ...between CTX-II and various ...

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Spinacia oleracea extract attenuates disease progression and sub chondral bone changes in monosodium iodoacetate induced osteoarthritis in rats

Spinacia oleracea extract attenuates disease progression and sub chondral bone changes in monosodium iodoacetate induced osteoarthritis in rats

... Rat CTX-II (ELISA KIT E-EL-R2554) and Rat COMP (ELISA kit E-EL-R0159) were purchased from Elabsciences (Elabsciences biotechnology co ltd, Hubei province, ...

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Developments in the scientific understanding of osteoarthritis

Developments in the scientific understanding of osteoarthritis

... type II collagen (CTX-II), and serum hyaluronan ...urinary CTX-II, serum hyaluronic acid [75], and pentosidine, an advanced glycation end-product ...urinary CTX-II is of ...

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Early Arthritics

Early Arthritics

... The CTx-II increased the RR of persistence of disease activity and development of erosions at 6 months, al- though this difference was not statistically ...urinary CTx-II has been shown to ...

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Nonclinical and clinical pharmacological characterization of the potent and selective cathepsin K inhibitor MIV 711

Nonclinical and clinical pharmacological characterization of the potent and selective cathepsin K inhibitor MIV 711

... Cathepsin K is a lysosomal cysteine protease predomi- nately expressed in osteoclasts, the cells responsible for bone resorption [1]. Osteoclasts form extracellular hemivacuoles in close contact with the bone surface [2] ...

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Hormone replacement therapy, calcium and vitamin D3 versus calcium and vitamin D3alone decreases markers of cartilage and bone metabolism in rheumatoid arthritis: a randomized controlled trial [ISRCTN46523456]

Hormone replacement therapy, calcium and vitamin D3 versus calcium and vitamin D3alone decreases markers of cartilage and bone metabolism in rheumatoid arthritis: a randomized controlled trial [ISRCTN46523456]

... of CTX-II, reflecting cartilage breakdown, were measured by a new competitive ELISA (CartiLaps; Nordic Bioscience A/S, Herlev, Denmark) based on a mouse monoclonal antibody raised against the EKGPDP ...

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Safety, tolerability and efficacy of intra articular Progenza in knee osteoarthritis: a randomized double blind placebo controlled single ascending dose study

Safety, tolerability and efficacy of intra articular Progenza in knee osteoarthritis: a randomized double blind placebo controlled single ascending dose study

... interval; CTX-I: C-terminal telopeptide of type I col- lagen; CTX-II: C-terminal telopeptide of type II collagen; CVs: coefficients of variation; ECG: electrocardiogram; HA: hyaluronic acid; ...

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Biochemical markers of ongoing joint damage in rheumatoid arthritis   current and future applications, limitations and opportunities

Biochemical markers of ongoing joint damage in rheumatoid arthritis current and future applications, limitations and opportunities

... type II procollagen) and PIICP (carboxyl terminus propeptide of type II procollagen) in collagen type I (a) and collagen type II (b) are used to defi ne protein formation, as they are released during ...

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Developing a toolkit for the assessment and monitoring of musculoskeletal ageing

Developing a toolkit for the assessment and monitoring of musculoskeletal ageing

... ary CTX-II and serum COMP are useful for assessing both the progression and incidence of OA in the knee and hip [25, 27, 30 – ...while CTX-II has been shown to increase in parallel with bone ...

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Circulatory pattern of cytokines, adipokines and bone markers in postmenopausal women with low BMD

<p>Circulatory pattern of cytokines, adipokines and bone markers in postmenopausal women with low BMD</p>

... We further observed that circulatory levels of bone markers (PINP, PINP/CTX ratio) as well as adipokines markers (adiponectin, adipsin, PA-1 and resistin) were not affected by age. However, all markers, except ...

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Gas phase characterization of the noncovalent quaternary structure of Cholera toxin and the Cholera toxin B subunit pentamer

Gas phase characterization of the noncovalent quaternary structure of Cholera toxin and the Cholera toxin B subunit pentamer

... the CTx B and SLTx B pentamers. Monomers from CTx B (A) and SLTx B (B) viewed either sideways (left) showing the interface region (dashed line) between monomers or from the top (right) of the ...

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Comparison of agar dilution, microdilution, and disk elution methods for measuring the synergy of cefotaxime and its metabolite against anaerobes

Comparison of agar dilution, microdilution, and disk elution methods for measuring the synergy of cefotaxime and its metabolite against anaerobes

... Reproducibility of MICs of CTX and des-CTX against three control strains by microdilution, agar dilution, and broth-disk elution systems Test for susceptibility to b: MIC range p.g/ml of[r] ...

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Determination of Phylogenetic Group and Prevalence of blaCTX-M and blaCTX-M-15 Genes in Escherichia Coli Isolates from Intestinal and Urinary Tract Infections in under Five- Year- Old Children

Determination of Phylogenetic Group and Prevalence of blaCTX-M and blaCTX-M-15 Genes in Escherichia Coli Isolates from Intestinal and Urinary Tract Infections in under Five- Year- Old Children

... 20.Blanco M, Alonso MP, Nicolas-Chanoine MH, Dahbi G, Mora A, Blanco JE, et al. Molecular epidemiology of Escherichia coli producing extended-spectrum b- lactamases in Lugo (Spain): dissemination of clone O25b:H4-ST131 ...

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Concurrent Chemoradiotherapy with or without Anti-EGFR-Targeted Treatment for Stage II-IVb Nasopharyngeal Carcinoma: Retrospective Analysis with a Large Cohort and Long Follow-up

Concurrent Chemoradiotherapy with or without Anti-EGFR-Targeted Treatment for Stage II-IVb Nasopharyngeal Carcinoma: Retrospective Analysis with a Large Cohort and Long Follow-up

... phase II study of concurrent CTX-CDDP and IMRT in locoregionally advanced NPC and reported the 2-year progression-free survival rate of ...of CTX, CDDP, and IMRT was a feasible strategy against ...

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