cullin 5
Evolutionarily Conserved Requirement for Core Binding Factor Beta in the Assembly of the Human Immunodeficiency Virus/Simian Immunodeficiency Virus Vif-Cullin 5-RING E3 Ubiquitin Ligase
... The human immunodeficiency virus type 1 (HIV-1)-encoded virion infectivity factor (Vif) is required to inactivate the host re- striction factor APOBEC3 by engaging Cullin 5 (Cul5)-RING ubiquitin ligase ...
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E4Orf6-E1B-55k-Dependent Degradation of De Novo-Generated Adeno-Associated Virus Type 5 Rep52 and Capsid Proteins Employs a Cullin 5-Containing E3 Ligase Complex
... a cullin 5-containing E3 ligase complex together with de novo-generated AAV5 capsid ...to cullin 5 (clone H-300, sc13014; Santa Cruz, ...to cullin 5a (37574; Santa Cruz, ...
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Identification of a Conserved Interface of Human Immunodeficiency Virus Type 1 and Feline Immunodeficiency Virus Vifs with Cullin 5
... containing Cullin 5 (CUL5) as well as Elongin B (ELOB) and Elongin C (ELOC) through a novel SOCS (suppressor of cytokine signaling) box that binds ELOC (7, ...
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Core Binding Factor Beta Plays a Critical Role by Facilitating the Assembly of the Vif-Cullin 5 E3 Ubiquitin Ligase
... T he cellular cytidine deaminases APOBEC3G (A3G) and APOBEC3F (A3F) are potent viral restriction factors that hy- permutate the viral DNA (1–6) and/or physically block reverse transcription (7–9). The HIV-1 virion ...
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The role of cullin 5-containing ubiquitin ligases
... Cullin 5 (Cul5) was originally identified as a vasopres- sin-activated calcium-mobilizing (VACM-1) protein, an arginine vasopressin (AVP) receptor ...
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Analysis of the Adenovirus E1B-55K-Anchored Proteome Reveals Its Link to Ubiquitination Machinery
... E1B-55K, Cullin-5, and Elon- gins B and C (97, ...E4-orf6, Cullin-5, Elongins B and C, and Rbx1/ROC1/Hrt1) were found in a complex of 800 to 900 kDa, much larger than the sum of their ...
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Dissection of the HIV Vif Interaction with Human E3 Ubiquitin Ligase
... and cullin box interact with the E3 ligase scaffold protein cullin 5 (Cul5) (11, 12, 20, ...Vif cullin box is not as conserved as those of cellular SOCS-box proteins, which have a defined ...
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Moloney leukemia virus 10 (MOV10) inhibits the degradation of APOBEC3G through interference with the Vif mediated ubiquitin–proteasome pathway
... ElonginB, Cullin 5, or CBF-β was amplified through reverse transcription-polymerase chain reaction (RT-PCR) with the mRNA of 293T cells as the ...inC, Cullin 5, or CBF-β was inserted into ...
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Human Papillomavirus Type 16 E7 Oncoprotein Associates with the Cullin 2 Ubiquitin Ligase Complex, Which Contributes to Degradation of the Retinoblastoma Tumor Suppressor
... with cullin 2 contain two sequence motifs that share some sequence simi- larity with BC boxes ...C-containing cullin 2 and cullin 5 ubiquitin ...a cullin 2 box-related sequence ...the ...
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"Cullin 4 makes its mark on chromatin"
... [1]. Cullin serves as a scaffold to assemble multi- subunit ubiquitin E3 ligase complexes through its C-ter- minal interaction with the small Ring finger-containing protein ROC1 or its homolog ROC2/APC11 and its ...
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The structure and regulation of Cullin 2 based E3 ubiquitin ligases and their biological functions
... type 5 (Ad5) early region 4 from open reading frame 6 (E4orf6) contained three BC boxes and formed an E3 ubiqutin ligase complex with Cullin 5 (Cul5) [124, 125], whereas the human adenovirus type 12 ...
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Original Article Cullin-1 promotes cell proliferation via cell cycle regulation and is a novel in prostate cancer
... of Cullin-1 and unravel its underly- ing molecular mechanism to develop novel treatment options equivalent to ...between Cullin-1 expression and clinicopathologic variables and patient sur- ...The ...
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Hyperkalemic hypertension–associated cullin 3 promotes WNK signaling by degrading KLHL3
... kinases, the ubiquitin scaffold protein cullin 3 (CUL3), or the substrate adaptor kelch-like 3 (KLHL3). Disease-associated CUL3 mutations abrogate WNK kinase degradation in cells, but it is not clear how mutant ...
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Structural Insight into the Human Immunodeficiency Virus Vif SOCS Box and Its Role in Human E3 Ubiquitin Ligase Assembly
... the Cullin box consensus ...11 Cullin-box residues, including leucine 163/178, valine 166/181, arginine 167/182, leucine 169/ 184, glutamate 171/186, and aspartate 172/187 ...SOCS2 Cullin boxes, ...
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Groh_unc_0153D_14160.pdf
... multicellular organisms. Decreased WDTC1 expression is associated with obesity in mice and humans. Yet, the molecular mechanism underlying its anti-obesity function remains elusive. WDTC1 is a candidate DWD protein (DDB1 ...
123
Mutant Cullin 3 causes familial hyperkalemic hypertension via dominant effects
... normal Cullin RING Ligase (CRL) function and proposed mechanisms of CUL3-Δ9–mediated familial hyperkalemic hypertension ...2 Cullin 3–containing (CUL3-containing) ...
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Cullin-3–dependent deregulation of ACTN1 represents a pathogenic mechanism in nemaline myopathy
... whether Cullin-3 could also be required for NMJ formation and ...for Cullin-3 during development of NMJs, an essential process for myogenesis and muscle growth ...that Cullin-3 and CRL activity ...
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Mechanistic Dissection of the Cop9 Signalosome’s Deneddylation Activity on Cullin-RING Ligases
... CRLs comprise a family of up to 240 enzymes that exert a profound effect on eukaryotic cells and organisms. CRLs, in aggregate, appear to account for ~20% of total protein degradation by the ubiquitin-proteasome system ...
138
Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome.
... CSN2 to bend upwards towards the CRL2. The plasticity of these N-terminal helices presumably permits the binding of deneddy- lated and alternative Cullin isoforms. HDX-MS further indicates that RBX1 and CSN4 form ...
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Depletion of the Cullin Cdc53p Induces Morphogenetic Changes in Candida albicans
... Candida albicans is an important opportunistic human fungal pathogen that can cause both mucosal and systemic infections in immunocompromised patients. Critical for the virulence of C. albicans is its ability to undergo ...
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