Cullin-RING E3 ligases
Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome.
... Cullin-Ring E3 Ligases (CRLs) regulate a multitude of cellular pathways through specific substrate receptors. The COP9 signalosome (CSN) deactivates CRLs by removing NEDD8 from activated ...
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Rotavirus NSP1 Requires Casein Kinase II Mediated Phosphorylation for Hijacking of Cullin RING Ligases
... N-terminal RING domain motif ...an E3 ubiquitin ligase, triggers I B ubiquitination and proteasomal degradation, allowing nuclear translocation of the NF- B heterodimer ...
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Genetic and molecular characterization of Roc-Cullin interactions in Drosophila melanogaster E3 ubiquitin ligases
... for Cullin proteins, the Roc proteins are structurally distinct, and specific RING domains play an important role in determining overall CDL function during ...
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The structure and regulation of Cullin 2 based E3 ubiquitin ligases and their biological functions
... CRLs: Cullin-RING E3 ubiquitin ligase complexes; Cul2: Cullin-2; Rbx1: RING protein; ECS: Elongin B and C-Cul2 or Cul5-SOCS box protein; VHL: von Hip- pel–Lindau; HIFα: α subunits of ...
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Cullin-RING ubiquitin ligases: global regulation and activation cycles
... the cullin is deneddylated and the SRS is protected from autoubiquitination ...other E3 ligases) allows deneddylation by the CSN ...from cullin-Rbx1 in the process of CAND1 ...involves ...
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E3 ubiquitin ligases and their control of T cell autoreactivity
... single-chain E3 ligases that regulate T cell function. (a) Multi-subunit E3 ligases (Skp1-Cullin-F-box (SCF), Cullin-Elongin BC-SOCS/VHL (CBC), and U-box) are anchored by a ...
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Atlas on substrate recognition subunits of CRL2 E3 ligases
... As E3 enzymes are the core effectors of ubiquitin- proteasome system, it is reasonably important to fully dissect their molecular ...that Cullin scaffold subunits, containing at least five conserved ...
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Emerging role of F-box proteins in the regulation of epithelial-mesenchymal transition and stem cells in human cancers
... [29]. E3 ligases are mainly divided into three major types: U-box domain, really interesting new gene (RING) domain, and homologous to E6-associated protein C-terminus (HECT) domain ...the ...
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Cullin-RING ligases in regulation of autophagy
... a RING protein, bind to the N-terminus and the C-terminus of CUL1, ...the RING protein binds to ubiquitin- charged E2 and effectively catalyzes the transfer of ubiq- uitin from E2 to the specific substrate ...
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Rotavirus NSP1 Associates with Components of the Cullin RING Ligase Family of E3 Ubiquitin Ligases
... an E3 ubiquitin ligase that is responsible for inducing the degrada- tion of IRF proteins and  -TrCP, but direct evidence for E3 ligase activity has been ...an E3 ligase is reiter- ated by this ...
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The Poxviral RING Protein p28 Is a Ubiquitin Ligase That Targets Ubiquitin to Viral Replication Factories
... oma virus homologue, M143R, are unknown, but they them- selves seem to be targets for ubiquitination, which may con- tribute to the observed accumulation of ubiquitin in the replication factories. It remains to be ...
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Ubc13: the Lys63 ubiquitin chain building machine
... the E3 ligase RNF8 (Figure 4) [70, 73, ...its RING domain to stimulate the formation of Lys63-linked ubiquitin chains [19, 38, ...a E3 ligase, HERC2, is sumoylated upon DSB induction and facilitates ...
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Arabidopsis BRUTUS-LIKE E3 ligases negatively regulate iron uptake by targeting transcription factor FIT for recycling
... different E3 ligases that are up-regulated dur- ing Fe deficiency (4, 14, 15) is a small gene family encoding E3 ubiquitin ligases with N-terminal hemerythrin ...motif-containing RING- ...
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The Molecular Basis of Substrate Recognition by the Family of Pellino E3 Ubiquitin Ligases
... catalytic RING domain is responsible for regulating TNFα-induced apoptosis [28]; thus, peptide-based inhibition can be a very specific way to block TNF signaling while preserving Pellino3 function in other immune ...
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Following Ariadne's thread: a new perspective on RBR ubiquitin ligases
... an E3 ubiquitin ligase. In most cases, E3 ubiquitin ligases assume the role of transferring activated ubiquitin from a restricted cohort of E2s to specific ...600 E3 ubiquitin ligases ...
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The ubiquitin-proteasome system: A novel target for anticancer and anti-inflammatory drug research
... suppress apoptosis, induce cell proliferation, promote angiogenesis and metastasis, and potentate inflammation [19, 20]. Therefore, small-molecule inhibitors that target the NF-κB activation pathway, including proteasome ...
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Herpes Simplex Virus Type 1 Immediate-Early Protein ICP0 and Its Isolated RING Finger Domain Act as Ubiquitin E3 Ligases In Vitro
... the E3 ligase activity, a plasmid was constructed that expresses GST-linked ICP0-241, a protein containing only residues derived from exons 1 and 2 of full-length ...similar RING finger- dependent assays ...
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Roles of Ubiquitination and SUMOylation in DNA Damage Response
... the E3 ligase Keap1 has been observed to specifically block the BRCA complex formation, rather than targeting PALB2 for degradation, thus suppressing HR (Orthwein et ...The RING-type E3 ligase RNF138 ...
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The Specificities of Kaposi's Sarcoma-Associated Herpesvirus-Encoded E3 Ubiquitin Ligases Are Determined by the Positions of Lysine or Cysteine Residues within the Intracytoplasmic Domains of Their Targets
... homologous E3 ligases, MIR1 and MIR2, that mediate the ubiquitination and subsequent downregulation of several cell surface proteins, and in particular major histocompatibility complex class I (MHC-I) ...of ...
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Groh_unc_0153D_14160.pdf
... multicellular organisms. Decreased WDTC1 expression is associated with obesity in mice and humans. Yet, the molecular mechanism underlying its anti-obesity function remains elusive. WDTC1 is a candidate DWD protein (DDB1 ...
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