CXC-chemokine
Initial Assessment of the Role of CXC Chemokine Receptor 4 after Polytrauma
... CXC chemokine receptor (CXCR)-4 agonists have been shown to attenuate inflammation and organ injury in various disease models, including trauma/hemorrhage. The pathophysiological role of CXCR4 during the ...
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CXC chemokine superfamily induced by Interferon-γ in asthma: a cross-sectional observational study
... IFN-γ–inducible protein 10 kDa (IP-10, CXCL10), monokine induced by IFN-γ (Mig, CXCL9), and IFN- inducible T cell a chemoattractant (I-TAC, CXCL11) be- long to the CXC chemokine subfamily that binds to ...
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CXC-Chemokine Receptor 4 Is Not a Coreceptor for Human Herpesvirus 7 Entry into CD4+ T Cells
... HHV-7 infection (1) and expresses CXCR4, was obtained from the American Type Culture Collection (Rockville, Md.) and was cultured in RPMI 1640 medium (Gibco BRL, Gaith- ersburg, Md.) supplemented with 10% ...
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CC and CXC chemokine levels in children with meningococcal sepsis accurately predict mortality and disease severity
... Serum levels of GRO-α, MIP-1α and MCP-1 were measured by ELISA (Quantikine; R&D Systems (Minneapolis, MN, USA) according to the manufacturer's instructions. Samples were first diluted 1:2 in the appropriate buffer ...
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Novel regulatory therapies for prevention of Graft-versus-host disease
... APC: antigen-presenting cells; BMT: bone marrow transplantation; CCR5: C-C chemokine receptor; CXCR3: CXC chemokine receptor 3; DC: dendritic cells; FC: facilitating cells; FoxP3: forkhe[r] ...
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Inflammogenic effect of well-characterized fullerenes in inhalation and intratracheal instillation studies
... the CXC chemokine family and consists of CINC-1, CINC-2ab, and CINC-3, not only stimulates the neutro- phil chemotactic activity but also enhances phagocytosis, induces adhesion molecules, and activates the ...
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HIV-induced immune activation - pathogenesis and clinical relevance. Summary of a workshop organised by the German AIDs Society (DAIG e.v.) and the ICH Hamburg, Hamburg, Germany, November 22, 2008
... A characteristic feature of these cells is the upregulation of cXcR5 which is the receptor for cXc-chemokine ligand 13 (cXcl13). In mice lacking cXcl13 or its receptor cXcR5, the ar- ch[r] ...
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BMP2 repression and optimized culture conditions promote human bone marrow-derived mesenchymal stem cell isolation.
... embryonic stem cell self-renewal or adoption of a neuronal fate.. Differential usage of the CXC chemokine receptors 1 and 2 by interleukin-8, granulocyte chemotactic protein-2 and epith[r] ...
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Chemokine (C-X-C Motif) Receptor 4 and Atypical Chemokine Receptor 3 Regulate Vascular α1-Adrenergic Receptor Function
... atypical chemokine receptor (ACKR) 3 ligands have been reported to mod- ulate cardiovascular function in various disease ...with CXC chemokine ligand 12 (CXCL12), or blockade of CXCR4 with AMD3100 ...
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Intracellular CXCR4<sup>+</sup> cell targeting with T22-empowered protein-only nanoparticles
... CXC chemokine receptor 4 (CXCR4) is a cell surface marker associated with several severe human pathologies, including colorectal cancer, for which intracellular targeting agents are cu[r] ...
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Plasma VCAM1 levels correlate with disease severity in Parkinson’s disease
... CC- Chemokine receptor 5; CD11b: Cluster of differentiation 11B; CXCR3: CXC-chemokine receptor 3; CXCR4: CXC-chemokine receptor 4; HD: Healthy donor; IFN- γ : Interferon gamma; ...
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Original Article Interaction between CXCR4 and EGFR and downstream PI3K/AKT pathway in lung adenocarcinoma A549 cells and transplanted tumor in nude mice
... CXC chemokine receptor 4 (CXCR4), a member of the G-protein-coupled receptor family, has received considerable attention since it has been demonstrated to be important in tumor metastasis ...[1]. CXC ...
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Relationship between epithelial-to-mesenchymal transition and the inflammatory microenvironment of hepatocellular carcinoma
... IL-8 is another important inflammatory factor secreted by TAMs in HCC. Its expression is associated with tumor growth and survival, as well as increased tumor invasion, migration and angiogenesis. Studies in MHCC97H and ...
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The Regulation and Interactions of the Hypoxia Inducible Factor Pathway in Carcinogenesis and Potential Cancer Therapeutic Strategies
... 2005 Epidermal Growth Factor and Hypoxia-Induced Expression of CXC Chemokine Receptor 4 on Non-Small Cell Lung Cancer Cells Is Regulated by the Phosphatidylinositol 3-Kinase/PTEN/AKT/Mam[r] ...
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Children are not little adults: just ask their hematopoietic stem cells
... of CXC chemokine ligand 12 (CXCL12, also known as stromal cell–derived factor 1 [SDF-1]), a chemokine previously implicated in stem cell trafficking to the marrow cavity and shown to be expressed by ...
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Sialic acid metabolism as a potential therapeutic target of atherosclerosis
... asialoglycoprotein receptors; CAD: Coronary artery disease; CMAH: Cytidine monophosphate N-acetyl-D-neuraminic acid hydroxylase CMP cytosine 5 ′ - monophosphate; CXCL1: CXC chemokine rec[r] ...
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Virologic and Immunologic Events in Hilar Lymph Nodes During Simian Immunodeficiency Virus Infection Development of Polarized Inflammation
... inflammatory CXC chemokine receptor 3 (CXCR3) ligands CXCL9, CXCL10, and CXCL11 were all consistently among the most upregulated mRNAs early and late after SIV ...
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A homeostatic function of CXCR2 signalling in articular cartilage
... ELR+ CXC chemokines are chemotactic cytokines characterised by their glutamic acid-leucine-arginine (ELR+) ...The chemokine receptor CXCR2 binds the human CXC chemokine ligands CXCL1, CXCL2, ...
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Dysregulation of chemokine receptor expression and function in leukocytes from ALS patients
... CC- chemokine receptor 2; CCR5: CC-chemokine receptor 5; CD11B: Cluster of differentiation 11B; CXCR3: CXC-chemokine receptor 3; CXCR4: CXC- chemokine receptor 4; INF- γ : ...
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SDF-1 Improves Renal Fibrosis in Type 2 Diabetes Mellitus Involving TGF-beta-mediated ECM via PI3K/AKT Signaling
... factor-1, CXC chemokine receptor 4 and F4/80 were ...factor-1, CXC chemokine receptor 4 and F4/80 was significantly increased in the kidney of db/db mice but not in C57BL/6 mice, which was ...
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