CXCL12 and CXCR4 Pathway
Recurrence of glioblastoma after radio-chemotherapy is associated with an angiogenic switch to the CXCL12-CXCR4 pathway
... of CXCR4 is further supported in our study by in vitro ...a CXCR4 antagonist on GBM explants isolated from three patients and demonstrated a greater anti-tumor effect with the combination of AMD3100 and ...
12
Osteotropism of neuroendocrine tumors: role of the CXCL12/ CXCR4 pathway in promoting EMT in vitro.
... as CXCR4 high /CXCL12 low , while H727 and CNDT 2.5 were CXCR4 low /CXCL12 high .... CXCL12 was inert on cell proliferation, but significantly increased the in vitro osteotropism of ...
16
Stromal-derived factor-1α/CXCL12-CXCR4 chemotactic pathway promotes perineural invasion in pancreatic cancer
... of CXCR4. In the model of PNI in vitro, CXCL12 promoted the directional outgrowth of DRG projecting toward PCa cells and these, in turn, experienced early morphologic changes at the migration front, ...
16
Emerging targets in cancer management: role of the CXCL12/CXCR4 axis
... the CXCR4-targeting anticancer therapy is a potential side effect on the stem cell compartment in normal ...of CXCR4 inhibition and conventional ...between CXCR4 and tumor initiating cells in cancer ...
15
CXCR7 prevents excessive CXCL12-mediated downregulation of CXCR4 in migrating cortical interneurons
... CXCR4 pathway in ...sequester CXCL12 through ...of CXCR4 throughout the cortex in mice expressing CXCL12, but not in CXCL12-deficient ...animals. Cxcl12 −/− mice lack ...
7
CXCR7 prevents excessive CXCL12 mediated downregulation of CXCR4 in migrating cortical interneurons
... CXCR4 pathway in ...sequester CXCL12 through ...of CXCR4 throughout the cortex in mice expressing CXCL12, but not in CXCL12-deficient ...animals. Cxcl12 −/− mice lack ...
7
Epithelial-to-mesenchymal transition in FHC-silenced cells: the role of CXCR4/CXCL12 axis
... whether CXCR4 is activated in MCF-7 shFHC cells and to what extent this activation might play a role in the induction of the EMT ...silencing, CXCR4 protein level increased of about two-fold, and the ...
15
The chemokine receptor CXCR4 and its ligand CXCL12 are activated during implantation and placentation in sheep
... the CXCL12/CXCR4 system may affect migration of immunocompetent cells into the uterus and aid in establishment and maintenance of maternal tolerance to the fetal ...whether CXCL12/CXCR4 ...
10
The CXCR4-CXCL12 axis in Ewing sarcoma: promotion of tumor growth rather than metastatic disease
... HIF1α-dependent CXCR4 activation, our analyses did not provide support for a contribution of hypoxia to CXCR4 expression in this ...and CXCR4 protein expression within individual tumor samples, ...
9
Targeting the CXCR4 pathway using a novel anti-CXCR4 IgG1 antibody (PF-06747143) in chronic lymphocytic leukemia.
... novel CXCR4 antagonist IgG1 antibody PF- 06747143 binds to CXCR4 with high affinity and blocks CXCL12-induced mechanisms including calcium flux and cell ...The CXCR4 antibody mediates CLL- B ...
17
The Role of CXCL12-CXCR4 Signaling Pathway in Pancreatic Development
... The CXCL12-CXCR4 signaling pathway has key roles in the vascular ...formation. Cxcl12 or Cxcr4 mu- tant embryos die before ...that CXCL12 and CXCR4 are expressed in the ...
7
CXCL12 and CXCR4 in adenocarcinoma of the lung: Association with metastasis and survival
... of CXCR4 by CXCL12 have been well characterized. Binding of CXCL12 to CXCR4 results in receptor dimerization and endosomal internalization of the receptor–ligand ...cell, CXCR4 ...
7
Blockade of CXCL12/CXCR4 signaling inhibits intrahepatic cholangiocarcinoma progression and metastasis via inactivation of canonical Wnt pathway
... is CXCR4. CXCR4 is a G protein-coupled chemokine receptor, encoded on chromosome 2 ...development, CXCR4 is expressed on progenitor cells, allowing the migration from their birthplace to their final ...
12
The CXCL12/CXCR4 chemokine ligand/receptor axis in cardiovascular disease
... receptor CXCR4 and its ligand CXCL12 play an important homeostatic function by mediating the homing of progenitor cells in the bone marrow and regulating their mobilization into peripheral tissues upon ...
23
Involvement of CXCR4/CXCR7/CXCL12 Interactions in Inflammatory Bowel Disease
... CXCR4 and CXCL12 are expressed by IECs in the normal intestinal mucosa [49-51], contributing to IEC migration, barrier maturation, and restitution [52], via cAMP-mediated cellular functions ...has ...
7
Original Article CXCL12 induces migration of Schwann cells via p38 MAPK and autocrine of CXCL12 by the CXCR4 receptor
... of CXCL12 after CXCL12 acts on SCs, thus, forming a positive feedback ...If CXCL12 is slowly released at the lesion, only a small amount of CXCL12 can play a pivotal ...
7
The CXCL12/CXCR4 signaling axis retains neutrophils at inflammatory sites in zebrafish
... the CXCL12/CXCR4 signaling axis in modulating neutrophil retention at inflammatory ...The CXCR4 antagonist AMD3100 was used to block the Cxcl12/Cxcr4 signaling axis ...the ...
13
Epithelial chemokine CXCL14 synergizes with CXCL12 via allosteric modulation of CXCR4
... to CXCR4 with high affinity, which was comparable to what we have reported for CXCL12, the principal ligand for CXCR4 ...of CXCL12 led to a complete loss of activity, which was in keeping with ...
15
CXCR4/CXCL12/CXCR7 axis is functional in neuroendocrine tumors and signals on mTOR
... of CXCR4/CXCL12/CXCR7 axis in tumors versus non-tumor tissues and it was used to compare the distribution of the markers investigated among the different tumor groups and with clinical and pathological ...
11
Notch1 signaling pathway promotes invasion, self-renewal and growth of glioma initiating cells via modulating chemokine system CXCL12/CXCR4
... of CXCR4 in GICs, proposed that CXCR4 positive cells have the capability of developing not only tumorspheres in serum-free medium (SFM) supplemented with growth factors, but also the other cardinal features ...
15