CXCL16/CXCR6
Original Article Co-expression of CXCL16 and CXCR6 is a risk factor for poor prognosis of patients with diffuse large B Cell lymphoma
... The CXCL16/CXCR6 axis is associated with inflammation in the tumor ...that CXCL16 can be resident as the membrane- associated molecule or proteolytically cleaved by the disintegrin-like ...
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CXCL16/CXCR6 chemokine signaling mediates breast cancer progression by pERK1/2-dependent mechanisms
... of CXCR6 in cytoskeleton organization, inhibitors of ERK1/2 and Rho/ROCK pathways were next ...by CXCR6 overexpression in both cells in presence of CXCL16 ...of CXCR6 expression by shRNAs in ...
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The roles of serum CXCL16 in circulating Tregs and gastrointestinal stromal tumor cells
... of CXCL16 and its sole receptor, CXCR6, has been demonstrated in many ...between CXCL16 or CXCR6 expression and ...detected CXCL16 and CXCR6 expression in GIST patient samples by ...
11
Dysregulated expression of MIG/CXCL9, IP 10/CXCL10 and CXCL16 and their receptors in systemic sclerosis
... of CXCR6 expression via hypoxia-inducible factor-1a ...of CXCR6 expres- sion on SSc ECs. In addition, CXCR6-expressing HUVECs migrate in response to CXCL16 ...that CXCL16/CXCR6 ...
10
Downregulation of MicroRNA eca-mir-128 in Seminal Exosomes and Enhanced Expression of CXCL16 in the Stallion Reproductive Tract Are Associated with Long-Term Persistence of Equine Arteritis Virus
... of CXCL16, a chemokine strongly implicated in EAV long-term persistence (21, 29–31), in the ...that CXCL16 mRNA constitutes a putative target of eca-mir-128 and that consequently, this miRNA may play a ...
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<p>Elevated expression of CXCL16 correlates with poor prognosis in patients with colorectal cancer</p>
... elevated CXCL16 expression in lung cancer or hepato- cellular carcinoma tissue promoted the proliferation and invasion of lung cancer cells via the NF- κ B pathway by regulating expressions of c-Rel, Rel-B, p105 ...
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Increased serum CXCL16 is highly correlated with blood lipids, urine protein and immune reaction in children with active nephrotic syndrome
... increased CXCL16 in renal transplant urine and related to increased CXCL16 in the distal tubule and collecting duct ...Currently, CXCR6 is the only known receptor of CXCL16. CXCR6 is ...
8
“Inverse signaling” of the transmembrane chemokine CXCL16 contributes to proliferative and anti-apoptotic effects in cultured human meningioma cells
... measured CXCL16 and CXCR6 mRNA ...to CXCL16, which was clearly detectable in all investigated samples, CXCR6 transcription was (nearly) ...detect CXCL16 expression by ...
11
CXCL16 regulates cisplatin-induced acute kidney injury
... that CXCL16 regulates cell adhesion and migration through interaction with its receptor - CXCR6 [10, 22, ...23]. CXCL16 has a proinflammatory effect on renal proximal tubular cells and potentiates ...
11
Bonzo/CXCR6 expression defines type 1–polarized T cell subsets with extralymphoid tissue homing potential
... The overall expression pattern of Bonzo on leuko- cytes in humans and mice is similar (13, 15). However, one notable difference is that Bonzo is expressed also by naive CD8 T cells in mice, while it is specifically ...
8
Plasma levels of the proangiogenic protein CXCL16 remains elevated for 1 month after minimally invasive colorectal cancer resection
... chemokine CXCL16 is found on leu- kocytes, endothelial cells, and other tissues that stimu- late EC proliferation and ...soluble CXCL16 shed from the membrane likely accounts for its activity. CXCR6 ...
8
CXCR6 expression in non-small cell lung carcinoma supports metastatic process via modulating metalloproteinases
... Sera from patients diagnosed with SCC (n = 17) or AC (n = 14), and from healthy controls (n = 9), were provided by Dr. Goetz H. Kloecker of the James Graham Brown Cancer Center, University of Louisville, Louisville, KY. ...
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<p>miR-873-5p Inhibits Cell Migration and Invasion of Papillary Thyroid Cancer via Regulation of CXCL16</p>
... as CXCL16 and its receptor CXCR6. 20 CXCL16 is aberrantly expressed in various cancers and could regulate cell proliferation, migration and invasion of the cancer ...carcinoma, CXCL16 is ...
10
Original Article A critical role of CXCR6 in murine myocardial ischemia-reperfusion injury through activating IL-17a producing iNKT cells
... of CXCR6 knockout (KO) ...receptor, CXCR6 [10, 11]. CXCR6 activation with ligands CXCL16 binding is essential for iNKT cells recruitment and homing ...that CXCL16 is a hallmark of ...
8
Original Article CXCR6 deficiency attenuates pressure overload-induced monocytes migration and cardiac fibrosis through downregulating TNF-α-dependent MMP9 pathway
... that CXCR6 defi- ciency significantly ameliorated IFN-γ secretion and autophagy during cardiac reperfusion inju- ry ...a CXCR6- dependent way. Ischemia reperfusion induced CXCR6 positive monocytes ...
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Distinct Patterns of Ccr5 Versus Alternative Coreceptor Dependence in Non-Natural Host Versus Natural Host Simmian Immunodeficiency Virus Infection
... For Maraviroc toxicity analysis, human PBMCs were stimulated for 3 days with PHA and IL-2 as above. Media was replaced with IL-2 and cells were plated 1×10 6 per well in a 6 well plate for 3 days of treatment with media ...
196
Urine VCAM 1 as a marker of renal pathology activity index in lupus nephritis
... Monocyte chemotactic protein-1 (MCP-1), vascular cell adhesion molecule-1 (VCAM-1) and CXC ligand 16 (CXCL16) have been documented to be increased within the kidneys, sera and urine of SLE patients and seem to ...
11
Simian Immunodeficiency Virus SIVagm Efficiently Utilizes Non-CCR5 Entry Pathways in African Green Monkey Lymphocytes: Potential Role for GPR15 and CXCR6 as Viral Coreceptors
... mRNA extraction and cDNA synthesis. Sorted cells were washed twice in PBS, and RNAs and genomic DNAs were extracted using an AllPrep DNA/RNA minikit (Qiagen) according to the manufacturer’s in- structions. RNAs were ...
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<p>ELR positive CXCL chemokines are highly expressed in an animal model of ulcerative colitis</p>
... and CXCL16 chemokines were increased, the expressions of CXCL9, CXCL10, CXCL11, CXCL12, and CXCL17 chemokines had no change, and the expression of CXCL14 was decreased compared to the control ...
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Original Article Simvastatin ameliorates renal lipidosis through the suppression of renal CXCL16 expression in mice with adriamycin-induced nephropathy
... serum CXCL16 in children with active NS was significantly higher than that in remissive NS and control ...serum CXCL16 was positively cor- related with blood lipids and 24-h urine protein but negatively ...
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