cycle arrest
Role of p53 in the etiology of type ii diabetes mellitus ''apoptosisversus cell-cycle arrest''
... Further accumulated evidence for cell-cycle arrest hypothesis came from the study of the percentage of reduction of β-cell mass required to develop type II diabetes in different species. It had been shown ...
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/M cell cycle arrest in the broiler’s kidney
... cell cycle in the ...cell cycle arrest. The commercial broilers’ growth cycle is about 42 days, and then they will be put into use for ...cell cycle arrest in the kidney of ...
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Acanthamoeba induces cell cycle arrest in host cells
... determine the effects of Acanthamoeba on pRb phosphoryla- tion, HBMEC and HCEC were incubated with Acanthamoe- ba followed by immunoprecipitation and Western blotting using anti-phospho-pRb and anti-pRb antibodies, ...
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Vpr-induced cell cycle arrest is conserved among primate lentiviruses.
... cell cycle arrest differences observed in this study, it seems unlikely that Vpr and Vpx affect the cell cycle through direct interaction with the CDC2 ...
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CCAAT/Enhancer Binding Protein α Interacts with ZTA and Mediates ZTA-Induced p21CIP-1 Accumulation and G1 Cell Cycle Arrest during the Epstein-Barr Virus Lytic Cycle
... lytic cycle by IgG treatment, and its expression then persisted throughout the lytic cycle ...cell cycle arrest, was found to be relatively unchanged throughout lytic-cycle induction in ...
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/M cell cycle arrest induced by AFB
... cell cycle arrest induced by AFB 1 , few reports focus on the relationship between AFB 1 and cell cycle in the jejunum, and the exact mechanism of G 2 /M cell cycle arrest induced by ...
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Cell Cycle Arrest and Cytotoxic Effects of SAHA and RG7388 Mediated through p21WAF1/CIP1 and p27KIP1 in Cancer Cells
... cell cycle arrest effects of SAHA and RG7388 on using MCF-7 and LNCaP cells.. The cytotoxicity, cell 29.[r] ...
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Metformin impairs growth of endometrial cancer cells via cell cycle arrest and concomitant autophagy and apoptosis
... cell cycle in cancer cell lines ...cell cycle arrest in Ishikawa cells ...cell cycle progression not only in G0/G1 but also in the G2/M ...cell cycle arrest re- sulted from a ...
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Cell cycle arrest of cdc mutants and specificity of the RAD9 checkpoint.
... mutant tested that showed an equivocal requirement for RAD9 for cell cycle arrest at the restrictive tem- perature; fewer cdc6 r a d 9 cells were arrested as large buds[r] ...
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Role of Baculovirus IE2 and Its RING Finger in Cell Cycle Arrest
... to arrest the cell cycle, resulting in the accumulation of enlarged cells with abnormally high DNA ...cell cycle progression in S ...to arrest the cell cycle but did not affect its ...
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Human Parvovirus B19 Nonstructural Protein (NS1) Induces Cell Cycle Arrest at G1 Phase
... and others have shown that NS1 expression induces cell death with apoptotic features in erythroid cells in vivo and in vitro, suggesting that NS1 is a viral apoptotic factor (7, 15, 19, 24). However, there was an obvious ...
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An overview of Cdk1-controlled targets and processes
... cell cycle delay or arrest in response to DNA replication stress or DNA damage, respectively ...cell cycle checkpoints is often presented as: DNA damage signals T damage sensors T signal transducers ...
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Preclinical development of HQP1351, a multikinase inhibitor targeting a broad spectrum of mutant KIT kinases, for the treatment of imatinib-resistant gastrointestinal stromal tumors
... Methods: The binding activities of HQP1351 with native or mutant KIT were first analyzed. Imatinib-sensitive GIST T1 and imatinib-resistant GIST 430 cells were employed to test the in vitro antiproliferative activity. ...
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Silencing of CXCR4 sensitizes triple-negative breast cancer cells to cisplatin
... Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer for which there is no effective treatment. Previously, we and others demonstrated that CXCR4 surface expression is an independent prognostic ...
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Filamin A interacting protein 1-like expression inhibits progression in colorectal cancer
... Filamin A interacting protein 1-like (FILIP1L) expression, which is decreased in various cancers, may inhibit carcinogenesis. In this study, we evaluated the effects of FILIP1L on oncogenic behavior and prognosis in ...
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Human Immunodeficiency Virus Type 1 Vpr Binds to the N Lobe of the Wee1 Kinase Domain and Enhances Kinase Activity for Cdc2
... 2 arrest, as shown in genetic studies of Schizosaccha- romyces pombe ...cell cycle arrest, a finding consistent with the inactive state of Cdc2 during G 2 cell cycle arrest (13, 18, ...
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High expression of Ras-related protein 1A promotes an aggressive phenotype in colorectal cancer via PTEN/FOXO3/CCND1 pathway
... To validate whether FOXO3 is a crucial functional down- stream of RAP1A, we constructed the specific plasmid to overexpress FOXO3 expression in CRC cells. The qRT-PCR and western blot indicated FOXO3 expression was ...
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<p>Lycorine exerts antitumor activity against osteosarcoma cells in vitro and in vivo xenograft model through the JAK2/STAT3 pathway</p>
... To validate whether lycorine inhibited cell proliferation by inducing cell cycle arrest, the cell cycle distribution of MNNG/HOS and U2OS cells was analysed after treatment.. with lycori[r] ...
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Praeruptorin A Inhibits Cervical Cancer HeLa Cell Growth and Invasion by Suppressing MMP-2 Expression and ERK1/2 Signaling
... PA induces cell cycle arrest at G0/G1 phase in human cervical cancer HeLa cells.. 107.[r] ...
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The HDAC Inhibitor Quisinostat (JNJ-26481585) Supresses Hepatocellular Carcinoma alone and Synergistically in Combination with Sorafenib by G0/G1 phase arrest and Apoptosis induction
... HDACs overexpression and/or abnormal hyper-activation have been reported to be involved in mostly malignant characters in HCC cells[27, 28]. Thus HDACis have been poured substantial attention for their considerable ...
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