cyclic AMP-dependent protein kinase
Cyclic AMP-Dependent Protein Kinase Catalytic Subunits Have Divergent Roles in Virulence Factor Production in Two Varieties of the Fungal Pathogen Cryptococcus neoformans
... that cyclic AMP-dependent protein kinase functions in a signaling cascade that regulates mating and virulence of Cryptococcus neoformans ...A protein kinase A (PKA) ...
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Toxoplasma gondii Cyclic AMP Dependent Protein Kinase Subunit 3 Is Involved in the Switch from Tachyzoite to Bradyzoite Development
... is dependent on a TgPKAc3 ...cAMP- dependent tachyzoite maintenance was ...the protein lysate from parental parasite Pru ⌬ ku80 ⌬ hxgprt (Parent), knockout clone Pru ⌬ ku80 ⌬ pkac3 (PKAc3KO), and ...
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Regulation of the Subcellular Localization of Cyclic AMP-Dependent Protein Kinase in Response to Physiological Stresses and Sexual Differentiation in the Fission Yeast Schizosaccharomyces pombe
... Another well-characterized function of S. pombe PKA is that of a repressor of sexual differentiation (10). During non-nutri- ent-limited vegetative growth, Pka1p inhibits sexual differen- tiation via transcriptional ...
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Nonstructural protein 3 of hepatitis C virus blocks the distribution of the free catalytic subunit of cyclic AMP-dependent protein kinase.
... of protein introduction ...of protein into a large number of cells with excellent viability after ...the protein (31) must be ...this protein (12, ...
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Effects of osmolality and oxygen availability on soluble cyclic AMP dependent protein kinase activity of rat renal inner medulla
... soluble cyclic (c)AMP- dependent protein kinase activity were examined in slices of rat inner ...and protein kinase activity ...and protein kinase activity ...
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Integration of Stress Responses: Modulation of Calcineurin Signaling in Saccharomyces cerevisiae by Protein Kinase A
... that cyclic AMP-dependent protein kinase A (PKA) phosphorylates and negatively regulates Crz1p activity by inhibiting its nuclear ...
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A cyclic AMP-responsive DNA-binding protein (CREB2) is a cellular transactivator of the bovine leukemia virus long terminal repeat.
... In the absence of the tax transactivator, the CREB2 protein and the cyclic AMP-dependent protein kinase A activate the BLV long terminal repeat at a basal expression level: trans activat[r] ...
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Cyclic AMP-Independent Regulation of Protein Kinase A Substrate Phosphorylation by Kelch Repeat Proteins
... Effect of gpb1 ⌬ gpb2 ⌬ mutations is not specific to Tpk2p. Deletion of GPB1 and GPB2 causes an increase in diploid pseudohyphal growth and haploid invasive growth, phenotypes that are characteristic of increased ...
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Tor and Cyclic AMP-Protein Kinase A: Two Parallel Pathways Regulating Expression of Genes Required for Cell Growth
... Cell growth is dependent upon ribosome biogenesis and translation. It is well established that the cAMP-PKA pathway has a positive role in regulating the expression of genes re- quired for cell growth, including ...
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Toxoplasma gondii Cyclic GMP-Dependent Kinase: Chemotherapeutic Targeting of an Essential Parasite Protein Kinase
... MAP kinase (12, 22), an enzyme that is inhibited by trisub- stituted imidazoles that are structurally related to compound 1, we targeted a conserved catalytic-site threonine in PKG from both ...p38 kinase, ...
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Regulation of the Epstein-Barr Virus C Promoter by AUF1 and the Cyclic AMP/Protein Kinase A Signaling Pathway
... immortalize B cells (66). In addition to CBF1, another cellular factor(s) binds the Cp EBNA2-responsive enhancer, called C promoter binding factor 2 (CBF2) (33, 44). We have recently reported that the CBF2 binding site ...
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The Mechanism of Activation of Hormone Sensitive Lipase in Human Adipose Tissue
... nonactivated hormone-sensitive lipase to its activated form, as indicated by a decrease in the activation subsequently obtainable in fractions prepared from such hormone-treated tissues. These findings strongly suggest ...
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Adenylyl Cyclase-Associated Protein Aca1 Regulates Virulence and Differentiation of Cryptococcus neoformans via the Cyclic AMP-Protein Kinase A Cascade
... conserved cyclic AMP (cAMP) signaling pathway controls cell functions in response to environmental cues in organisms as diverse as yeast and ...cyclase-associated protein, Aca1, which functions in ...
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Smooth muscle cell expression of type I cyclic GMP dependent protein kinase is suppressed by continuous exposure to nitrovasodilators, theophylline, cyclic GMP, and cyclic AMP
... Immunological quantitation of PK-G I from tissue culture. Primary cultures of rat aortic SMC were plated in 35-mm culture dishes and treated with 8-CPT-cGMP. PK-G I levels were determined from crude soluble fractions as ...
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Cross Talk between the Cell Wall Integrity and Cyclic AMP/Protein Kinase A Pathways in Cryptococcus neoformans
... CWI kinase deletion ...Hog1 kinase is known to be a negative regulator of capsule syn- thesis in serotype A (33), a process that requires ...CWI kinase deletion ...the kinase deletion strains ...
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Reduced Activity of Mutant Calcium Dependent Protein Kinase 1 Is Compensated in Plasmodium falciparum through the Action of Protein Kinase G
... Western blot analysis. Western blot analysis was performed to detect the thiophosphorylated products of the in vitro kinase reaction. Briefly, the samples in 1 ⫻ LDS sample buffer were separated by 4 to 12% PAGE ...
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Carboplatin Enhances the Activity of Human Transient Receptor Potential Ankyrin 1 through the Cyclic AMP-Protein Kinase A-A-Kinase Anchoring Protein (AKAP) Pathways
... Lumbar DRG were isolated from mice and then homogenized in lysis buffer . Next, protein samples were diluted in sodium dodecyl sulfate sample buffer. After heating at 95°C for 5 min, equal amounts of proteins were ...
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Protein kinase C phosphorylates AMP-activated protein kinase α1 Ser487
... anti-protein kinase C (PKC)α, anti-PKCζ, anti-phospho-protein kinase D (PKD)/PKCm (Ser916), anti-PKD/PKCm antibodies and mouse anti-Akt, anti-phospho-ERK1/2 (Thr202/Tyr204) antibodies were ...
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Energy-Dependent Modulation of Glucagon-Like Signaling in Drosophila via the AMP-Activated Protein Kinase
... ABSTRACT Adipokinetic hormone (AKH) is the equivalent of mammalian glucagon, as it is the primary insect hormone that causes energy mobilization. In Drosophila, current knowledge of the mechanisms regulating AKH ...
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Low level genome mistranslations deregulate the transcriptome and translatome and generate proteotoxic stress in yeast
... reduced protein synthesis rate by 15%, as measured by [ 14 C]-aa pulse-labeling of proteins (Fig- ure ...of protein synth- esis; however, polysomes content and protein synthesis rate may not be ...
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