Cyclic nucleotide-gated
An investigation into the role of the hyperpolarisation-activated cyclic nucleotide-gated on channels in dorsal root ganglion neurons in rat models of chronic inflammatory and neuropathic pain
... Using!animal!models!of!chronic!pain!{CP},!which!included!the!complete!Freund’s! adjuvant! {CFA}! model! of! hindlimb! inflammation! and! the! surgically! induced! modified! spinal! nerve! axotomy! {mSNA}! model! of! ...
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Molecular Mechanisms of a Retinal Cyclic Nucleotide-Gated Channel
... Cyclic nucleotide-gated (CNG) channels mediate the transduction of light signals to electrical signals in vertebrate photoreceptors. These channels are non-selective for cations and open upon cGMP ...
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Phylogeny and effects of anoxia on hyperpolarization activated cyclic nucleotide gated channel gene expression in the heart of a primitive chordate, the Pacific hagfish (Eptatretus stoutii)
... Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, which play an important role in establishing the pacemaker rate of vertebrate hearts, were postulated to be present in this ...
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CURRENT UNDERSTANDING OF HYPERPOLARIZATION ACTIVATED AND CYCLIC NUCLEOTIDE GATED (HCN) CHANNELS: A REVIEW
... Hyperpolarization-activated and Cyclic Nucleotide-gated (HCN) channels with significant physiological role are found to be present in heart and brain. These channels have got four subtypes encoded by ...
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The role of an ancestral hyperpolarization activated cyclic nucleotide gated K+ channel in branchial acid base regulation in the green crab, Carcinus maenas
... hyperpolarization-activated cyclic nucleotide-gated potassium channel (HCN) in the transcriptome of the green crab Carcinus maenas and subsequent performance of quantitative real-time PCR revealed ...
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The expression of hyperpolarization activated cyclic nucleotide gated (HCN) channels in the rat ovary are dependent on the type of cell and the reproductive age of the animal: a laboratory investigation
... activated cyclic nucleotide gated (HCN) channels generate a pacemaker current (I h ) that controls spontaneous pacemaker activity in the heart and brain ...and cyclic nucle- otide binding ...
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Hyperpolarization-activated cyclic nucleotide gated channels: a potential molecular link between epileptic seizures and Aβ generation in Alzheimer’s disease
... Conclusion: Because HCN1 associates with amyloid- β precursor protein (APP) and X11/X11L in the brain, genetic deficiency of X11/X11L may induce aberrant HCN1 distribution along with epi[r] ...
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Becirovic, Elvir (2010): Role of the CNGB1a Subunit of the Rod Cyclic Nucleotide-Gated Channel in Channel Gating and Pathogenesis of Retinitis Pigmentosa. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... Fig. 12 In silico analysis of the G993V mutation. A) Sequence alignment of the β2- α C region of the CNBD of human CNGB1a, human CNGA1, E. coli CAP, sea urchin (sp) HCN1 and human PKG1. Invariant residues are highlighted ...
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Modulation of cyclic nucleotide gated channels and regulation of vertebrate phototransduction
... of cyclic nucleotides (Broillet and Firestein, 1996), but there is no evidence that NO has a direct affect on photoreceptor CNG channels (Trivedi and Kramer, ...
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Differential expression of hyperpolarization-activated cyclic nucleotide-gated channel subunits during hippocampal development in the mouse
... Moreover, we observed a relatively intense labeling for HCN1 in the SR of the CA, particularly in the CA3 (Figure 3e and i), compared to the expression of HCN2 (Figure 4E, I) and HCN4 (F[r] ...
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Original Article Lidocaine may contribute to general anesthesia by different mechanisms in mammalian central nervous system
... hyperpolarization-activated cyclic nucleotide-gated (HCN) channels blocker ZD 7288 or N-methyl-D-aspartic acid (NMDA) receptor blocker MK-801, and hypnotic actions of these local anesthetics, were ...
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The effects of cyclophosphamide and its derivatives on cyclic nucleotide metabolism
... Cyclic nucleotide phosphodiesterases (PDE) catalyse the irreversible hydrolysis of the 3 '-bond of cyclic nucleotides to produce the non-cyclic nucleotide ...a cyclic ...
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Development of molecular assays to detect target site mechanisms associated with insecticide resistance in malaria vectors from Latin America
... single nucleotide polymorphisms (SNPs) which produce amino acid changes on insecticide target-sites (target- site resistance) [16]. The most studied mechanisms in Anopheles are those related to metabolic and ...
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Cyclic Nucleotide induced Maturation of Human Promyelocytic Leukemia Cells
... morphologically. Formyl-peptide receptor expression was the earliest marker of these modified programs of maturation. The receptor appeared within 2 h after treatment and increased linearly for 72 h. Receptor expression ...
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Cyclic nucleotide metabolism during the development of murine thymic lymphoma
... hepatic cyclic AMP-PK followed by the induction of ornithine decarboxylase (ODC), the rate limiting enzyme in the biosynthetic pathway of ...increased cyclic AMP-PK activity ratio and ODC activity resulting ...
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Cyclic nucleotide phosphodiesterase 3A–deficient mice as a model of female infertility
... Immunofluorescence. Twenty to 30 oocytes were fixed for 1 hour at room temperature (rt) in 2% paraformaldehyde in PBS, washed 5 times in blocking solution (PBS, pH7.4, containing 0.3% BSA [Sigma-Aldrich] and 100 mM ...
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Presence of the point mutations Val1016Gly in the voltage gated sodium channel detected in a single mosquito from Panama
... the nucleotide sequence of the para gene and leads to changes in some amino acids of the voltage-gated sodium channel (VGSC) protein, which causes a re- duction of the binding with the insecticide and, con- ...
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Excitation contraction coupling in the rat anococcygeus muscle
... the cyclic nucleotide ratio is important in determining the tension produced by the ...see cyclic nucleotide results, table R3 ...in cyclic nucleotide ...
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Oscillations of cyclic nucleotide concentrations in relation to the excitability of Dictyostelium cells
... After, however, calcium had been returned, the cyclic nucleotide concentrations remained at the basal levels, similar to the suppression of the second cGMP and cAMP peaks in excitable ce[r] ...
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Overexpression of rod photoreceptor glutamic acid rich protein 2 (GARP2) increases gain and slows recovery in mouse retina
... The CNG channels are critical in converting the chem- ical events during light activation into an electrical signal, which is relayed to the bipolar cells [4,5]. The rod CNG channel is a heterotetramer consisting of 3 α ...
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