Cyclin B/cdc2
Activation of Cdc2/cyclin B and inhibition of centrosome amplification in cells depleted of Plk1 by siRNA
... Plk1 Depletion Prevents Cyclin B Degradation and Causes Elevated Cdc2 Activity. To investigate the function of Plk1 in mammalian cells, we synthesized a RNA duplex directed against the coding region ...
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<p>Diosmetin Inhibits Cell Proliferation, Induces Cell Apoptosis and Cell Cycle Arrest in Liver Cancer</p>
... of Cdc2. 29 This results in a decrease in the expression of cyclin B/cdc2; therefore, the DIOS-induced cell cycle arrest in G2/M phase may be through the induction of the cyclinB1/cdc2 ...
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Cyclin B in fission yeast mitosis and meiosis
... the cdc2-cyclin B complex remains high to maintain metaphase (Murray et ...of cyclin proteins when activated to do ...of cyclin with the exception that its destruction is associated ...
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Overexpression of Cyclin A Inhibits Augmentation of Recombinant Adeno-Associated Virus Transduction by the Adenovirus E4orf6 Protein
... and cyclin A, two cellular proteins involved in the control of cell cycle progression, were down-regulated specifically upon E4orf6 expression ...Moreover, cyclin A and p53 levels remained low in E4orf6- ...
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Expression of Cyclin A in Rectal Mucosa and Rectal Carcinoma.
... p34 cdc2 (CDK1) is a highly conserved cyclin associated 34 KDa protein kinase that becomes activated on ...with cyclin B it forms the maturation promoting factor ...p34 cdc2 the cells ...
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The Identification of Wos2, a p23 Homologue That Interacts With Wee1 and Cdc2 in the Mitotic Control of Fission Yeasts
... the Cdc2 subunit on Tyr15 (Gould and vital role in thermotolerance and stress responses, the Nurse ...the Cdc2-cyclin B complex ...of Cdc2 by Wee1 in fission yeasts led to the identifi- ...
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Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B.
... acid, despite the block to DNA replication (41). It is believed that okadaic acid, a specific inhibitor of protein phosphatases 1 and 2A, bypasses this cell cycle checkpoint by inhibiting a phosphatase other than cdc25C ...
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Cytomegalovirus infection induces high levels of cyclins, phosphorylated Rb, and p53, leading to cell cycle arrest.
... and cdc2, remained relatively constant during cell cycle progression in the control cells, and no apparent modi- fication of their steady-state levels was induced by HCMV infection ...of cyclin E protein ...
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Sulforaphane induced cell cycle arrest in the G2/M phase via the blockade of cyclin B1/CDC2 in human ovarian cancer cells
... of cyclin B1 and Cdc2 in PA-1 ...[16]. Cdc2 regulates mitosis and binds to cyclin B to form mitosis-promoting factor (MPF) ...of Cdc2 as well as the accumulation of cyclin ...
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cdc2 Cyclin-Dependent Kinase Binds and Phosphorylates Herpes Simplex Virus 1 UL42 DNA Synthesis Processivity Factor
... activated cdc2 forms a heterodimer with its cognate partner, cyclin A or cyclin ...and B are no longer detectable at the time after infection when cdc2 is fully active, it could be ...
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The Cdc20 (Fzy)/Cdh1 related protein, Cort, cooperates with Fzy in cyclin destruction and anaphase progression in meiosis I and II in Drosophila
... of cyclin destruction in the two meiotic divisions is less ...whether cyclin destruction is necessary for female meiosis in Drosophila, we examined meiotic progression in eggs from females expressing a ...
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<p>New Isatin–Indole Conjugates: Synthesis, Characterization, and a Plausible Mechanism of Their in vitro Antiproliferative Activity</p>
... of B cell translocation gene 1, cell cycle-associated proteins (cyclin B1, cyclin D1, and phos- phorylated cyclin-dependent kinase 1), and a pro-apoptotic protein (Bcl-2-associated X protein ...
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The role of B-type cyclin synthesis during meiotic maturation of Xenopus oocytes
... of B-type cyclin synthesis similarly prevented entry into Mil: antisense-injected oocytes did not reactivate MPF, did not form a normal M il spindle, and appeared very similar to CHX-treated oocytes (the ...
164
Cyclin B in Oral Squamous Cell Carcinoma –Mini Review
... regulation. Cyclin B which belongs to the group of M cyclins is responsible for the G2/M transition and also the mitotic ...process. Cyclin B1 has been implicated in many cancers including Oral ...
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<p>CircHIPK3 Facilitates the G2/M Transition in Prostate Cancer Cells by Sponging miR-338-3p</p>
... the cyclin-dependent kinase Cdc2 to make it ...for Cdc2 to enter into mitosis. 31 Cdc2 is a key player in the transition of G2/M in mitotic ...and Cdc2 as well as increased the ...
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Molecular Characterization of Diffuse Large B-Cell Lymphoma and It’s Prognostic Significance.
... and Cyclin D2 on the modulation of the mitogenic effect of CDK4/6, four subgroups were created based on various combinations of p16 and Cyclin D2 expression namely subgroup 1 (p16+/Cyclin D2+), ...
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WWC3 downregulation correlates with poor prognosis and inhibition of Hippo signaling in human gastric cancer
... Notes: (A) Protein and mrna expression of WWc3 and YaP in gastric cancer cell lines was lower than that in normal ges-1 cell line. hgc-27 cell line has relatively low expression and sgc-7901 cell line has relatively high ...
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Original Article Amplified RPS6KB1 and CDC2 genes are potential biomarkers for aggressive HIV+/EBV+ diffuse large B-cell lymphomas
... the B-cell lymphomas with amplified RPS6KB1 and/or CDC2 in this study are negative for CD10, a germinal center marker with good ...and CDC2 versus CD10 had been observed when we first identified the ...
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GPER-1 acts as a tumor suppressor in ovarian cancer
... 1:1000), cyclin B1(#4138, Cell signalling, Frankfurt am Main, Germany, diluted 1:1000), Cdc2 (#9112, Cell signalling, Frankfurt am Main, Germany, diluted 1:2000) phosphoH3(Ser10) (#9701, Cell signalling, ...
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Aberrant accumulation of PTTG1 induced by a mutated thyroid hormone β receptor inhibits mitotic progression
... 4, compare I and M) was mainly nuclear. Figure 4, B, F, J, and N, show that PTTG1 was mainly concentrated in the nucleus, but cytoplasmic PTTG1 was also apparent. When the F-TRβ1 or F-PV and PTTG1 images were ...
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