Cyclin D1
Inhibition of basal and mitogen stimulated pancreatic cancer cell growth by cyclin D1 antisense is associated with loss of tumorigenicity and potentiation of cytotoxicity to cisplatinum
... that cyclin D1 overexpression in a human fibrosar- coma cell line is associated with increased resistance to meth- otrexate (50), indicating that cyclin D1 overexpression can con- tribute to ...
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Deshpande, Anagha (2009): Role of 3’UTR Elements in the Regulation of the Cyclin D1 Proto-oncogene. Dissertation, LMU München: Medizinische Fakultät
... above, cyclin D1 has been reported to be one of the key regulators of cell cycle machinery especially in G1 to S ...1998). Cyclin D1 encodes the regulatory subunit of the serine-threonin ...
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Original Article Upregulation of ATF-3 is correlated with prognosis and proliferation of laryngeal cancer by regulating Cyclin D1 expression
... detect Cyclin D1 expression after ATF-3 downregulation in Hep-2 ...of Cyclin D1 was decreased after ATF-3 downregulation in Hep-2 ...with Cyclin D1 ...
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Coordinated regulation of differentiation and proliferation of embryonic cardiomyocytes by a jumonji (Jarid2) cyclin D1 pathway
... when cyclin D1-CDK4 was added ...by cyclin D1-CDK4 in ...for cyclin D1 and CDK4 expression were transfected into HeLa cells, and the levels of signals for phosphorylation at S105 ...
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Original Article Cyclin D1 expression is associated with stage, grade and survival in urinary bladder carcinoma
... of cyclin D1 immunoexpression in bladder neoplasm was found to be related to muscula- ris propria invasion, vascular invasion, lymph node ...of cyclin D1 may lead to changes in the biological ...
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Cyclin D1 and P27KIP1: The Gatekeepers of Dysplasia
... CDK complexes is modulated by the phosphorylation of threonine residues on the CDK, and by interactions with cyclin dependent kinase inhibitors (CDI). The proper and timely action of all these mechanisms is the ...
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Cyclin D1 Expression in Laryngeal Cancer.
... Cyclin D1 gene transcriptional activity normally strictly depends on mitogen stimulation, and leads to cell commitment to mitosis through START checkpoint. An early CCND1 over expression is often ...
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ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice
... Cyclin D1 associates with genes involved in ...of cyclin D1–associated genes, based on percent enrichment score of the top ...(B) Cyclin D1–bound promoter regions (0 to –500 bp) ...
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Cyclin A and cyclin D1 as significant prognostic markers in colorectal cancer patients
... that cyclin D1 was the only protein in their panel (cyclin D1, p53, p16, Rb-1, PCNA and p27) that correlated with improved outcome in CRC ...between cyclin D1 overexpression and ...
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Cyclin D1 and p16 expression in recurrent nasopharyngeal carcinoma
... lins, cyclin-dependent kinases (CDKs), and CDK-inhibi- ...phase, cyclin D1 appears to be most strongly implicated in human carcino- ...genesis. Cyclin D1, through its interaction with ...
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Chromatin remodeling gene ARID2 targets cyclin D1 and cyclin E1 to suppress hepatoma cell progression
... E2F1, cyclin D1, and cyclin E1, induction of CDK4, and phosphorylation of ...of cyclin D1 and cyclin ...supporting cyclin D1 and cyclin E1 as direct targets ...
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The elements of human cyclin D1 promoter and regulation involved
... activted cyclin D1 promoter ...activates cyclin D1 promoter (Chu et ...of cyclin D1 promoter (Fassett et ...downregulation cyclin D1 due to inhibition of CREB ...
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Characterization of cytoplasmic cyclin D1 as a marker of invasiveness in cancer
... Cyclin D1 (Ccnd1) is a proto-oncogen amplified in many different cancers and nuclear accumulation of Ccnd1 is a characteristic of tumor ...of cyclin D1, we have built a variant (Ccnd1-CAAX) ...
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Variations in cyclin D1 levels through the cell cycle determine the proliferative fate of a cell
... that cyclin D1 levels are suppressed during S phase to ensure that proliferation continues only in cells with a positive growth environment during the succeed- ing G2 ...of cyclin D1 levels ...
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Expression of Cyclin D1 in normal and hyperplastic endometrium
... 13. Quddus MR, Latkovich P, Castellani WJ, Sung CJ, Steinhoff MM, Briggs RC, et al. Expression of cyclin D1 in normal, metaplastic, hyperplastic endometrium and endometrioid carcinoma suggests a role in ...
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Cyclin D1 expression in colorectal cancer is a favorable prognostic factor in men but not in women in a prospective, population-based cohort study
... between cyclin D1 expression and more favorable clinicopathological features might in part explain the lack of an independent prognostic value for cyclin D1 in male CRC, although the ...
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An analysis of Cyclin D1, Cytokeratin 5/6 and Cytokeratin 8/18 expression in breast papillomas and papillary carcinomas
... 5/6. Cyclin D1 over-expression leads to the sustained proliferation of mammary epithelial cells, which is associated with a delay in acinar development in vitro models [27] and a failure to undergo terminal ...
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Correlation between Cyclin D1 expression and Clinical behaviour in Squamous Cell Carcinoma of the Penis.
... that cyclin D1 was not an important factor in colorectal adenocarcinomas, recent work has shown not only does cyclin D1 over expression occur as an early event in tumor progression, it may ...
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Epstein-Barr Virus encoded LMP1 regulates cyclin D1 promoter activity by nuclear EGFR and STAT3 in CNE1 cells
... to Cyclin D1 over- expression is a common occurrence in human cancers (including NPC), and both EGFR and STAT3 could tar- get cyclin D1 promoter activity ...the cyclin D1 ...
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Immunohistochmical Expression of Cyclin D1 Protein in Sudanese patients with thyroid cancer
... Methods:- A total number of forty (40) Formalin fixed-paraffin embedded sections were collected from Sudanese patients with thyroid carcinoma; registered in who underwent surgery at many hospitals Such as (Ministry of ...
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