cyclin-dependent kinase
The cyclin-dependent kinase PITSLRE/CDK11 is required for successful autophagy
... the cyclin- dependent kinase, PITSLRE and its human ortholog CDK11 as critical regulators of basal ...(CDC)-related kinase belonging to the p34 cdc2 ...
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Retroviral Cyclin Enhances Cyclin-Dependent Kinase-8 Activity
... of cyclin-dependent kinase-8 (CDK8) or its partner, cyclin C, have been clearly associated with cancers, including colon cancer, melanoma, and ...retroviral cyclin (RV-cyclin) ...
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Cyclin dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis
... Genetic variation at the chromosome 9p21 risk locus promotes cardiovascular disease; however, it is unclear how or which proteins encoded at this locus contribute to disease. We have previously demonstrated that loss of ...
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Retroviral Cyclin Controls Cyclin-Dependent Kinase 8-Mediated Transcription Elongation and Reinitiation
... retroviral cyclin (RV-cyclin), encoded by WDSV, has separable cyclin box and tran- scription activation ...to cyclin-dependent kinase 8 (CDK8) and enhances its kinase ...
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Cyclin-dependent kinase 2 is an ideal target for ovary tumors with elevated cyclin E1 expression
... that Cyclin E1 (CCNE1) was overexpressed in 30% of established ovarian cancer cell ...of cyclin-dependent kinase 2 (Cdk2), we investigated the effect of Cdk2 inhibitor on ovary ...
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Cyclin-dependent kinase 4 is a preclinical target for diet-induced obesity
... The tumor suppressor pRb binds and represses the E2F family transcription factors, acting as a master regulator of the G 1 to M checkpoint during the cell cycle. In adult neurons, pRb is critical for maintaining the ...
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Modulation of apoptosis by the cyclin dependent kinase inhibitor p27Kip1
... 1997. Cyclin kinase inhibitors are increased during experimental membranous nephropathy: potential role in limiting glomerular epithelial cell proliferation in ...Human cyclin-dependent ...
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Indirect p53-dependent transcriptional repression of Survivin CDC25C , and PLK1 genes requires the cyclin-dependent kinase inhibitor p21/CDKN1A and CDE/CHR promoter sites binding the DREAM complex
... When looking at p53 association with DNA by ChIP, no significant binding of p53 was observed to the promoters of Survivin, CDC25C, and PLK1, in contrast to the promoters of cyclin-dependent kinase ...
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Downregulation of cyclin dependent kinase 2 activity and cyclin A promoter activity in vascular smooth muscle cells by p27(KIP1), an inhibitor of neointima formation in the rat carotid artery
... of cyclin-dependent kinase 2 (cdk2) activity in serum-deprived VSMCs was associated with the formation of complexes between cdk2 and its inhibitory protein p27(KIP1) ...of cyclin A promoter ...
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Cyclin-Dependent Kinase 1/Cyclin B1 Phosphorylates Varicella-Zoster Virus IE62 and Is Incorporated into Virions
... of cyclin-dependent kinase (CDK) ...cellular kinase in VZV ...cellular kinase complex interacts with ...of cyclin B1 from VZV-infected HFFs indicated that IE62 was included in ...
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Optimization of luminescent assay for screening of cyclin-dependent kinase 2 inhibitors
... compromised. Cyclin-dependent kinases ensure the tight regulation of the cell cycle execution by mediating phosphorylation of cellular ...the cyclin-dependent kinase 2 activity by ...
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Transcriptional Up-Regulation of the Cyclin D2 Gene and Acquisition of New Cyclin-Dependent Kinase Partners in Human T-Cell Leukemia Virus Type 1-Infected Cells
... the cyclin D2 transcripts were translated, we performed a series of Western blot analyses using estab- lished infected cell lines (IL-2 independent) as well as cells from ATL and HAM/TSP patients (IL-2 ...1B, ...
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Cyclin-Dependent Kinase Inhibitor AT7519 as a Potential Drug for MYCN-Dependent Neuroblastoma.
... Neuroblastoma are pediatric tumours that originate from the developing sympathetic nervous system. Current treatment regimens for high-risk tumours comprise a combination of high-dose cytostatics, radiation therapy, ...
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Regulation of the G1-S transition by cyclin-dependent kinase inhibitors
... While the studies presented here focused on tissues which showed a hyperproliferation upon p16 Ink4a and p18 Ink4c loss, we have embarked on a more extensive study of tissues affected by cdk4/6 inhibition in an effort to ...
103
Pharmacokinetics and biodistribution of the cyclin-dependent kinase inhibitor -CR8- in mice
... cell death induction. The drug passes the BBB at a level sufficient to reach concentrations able to inhibit neur- onal kinase targets. Bone marrow exposure was about 30% of that found as systemic exposure, a ...
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Cyclin dependent kinase regulation in haemopoietic cells
... is dependent on ribosomal numbers, CD34+ cells may have the machinery to dramatically increase their rate of protein synthesis and enter the division cycle in response to the appropriate ...
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Penta O galloyl β D glucose induces G1arrest and DNA replicative S phase arrest independently of P21 cyclin dependent kinase inhibitor 1A, P27 cyclin dependent kinase inhibitor 1B and P53 in human breast cancer cells and is orally active against triple negative xenograft growth
... protein kinase), a well-known autophagy signaling kinase in response to nutrient deprivation [18]; and by increased phosphatidylethanolamine modification of the microtu- bule-associated protein 1 light ...
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Regulation of Ciz1 by Cyclin A Cyclin Dependent Kinase 2 (CDK2) mediated phosphorylation
... 21 replication foci (Łukasik et al., 2008). ERH was first identified some years ago as an orthologue of a gene found in Drosophila. However, the precise function of this protein has still not been fully explained. ERH is ...
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Cyclin dependent kinase 12, a novel drug target for visceral leishmaniasis
... Extended Data Table 6: Sensitivity of WT and compound 5-resistant intramacrophage amastigotes INMAC to the compound series... Host cell pXC50..[r] ...
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Transcriptional Downregulation of p27KIP1 through Regulation of E2F Function during LMP1-Mediated Transformation
... is dependent upon activation of a specific NF- B complex containing Bcl-3 and dependent upon STAT3 activa- tion (39, ...signal-regulated kinase (ERK) pathways and PI3K, and inhibition of these ...
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