Cyclin-dependent kinase 1 (CDK1)
Cyclin-Dependent Kinase 1/Cyclin B1 Phosphorylates Varicella-Zoster Virus IE62 and Is Incorporated into Virions
... a 1:40 dilution of rPOka/HFFs for 2 h. Fresh medium containing 50 M CDK1 inhibitor III (Calbiochem, San Diego, CA) or an equal volume of dimethyl sulfoxide (DMSO) was added, and the medium was refreshed ...
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Mitotic p21 Cip1/CDKN1A is regulated by cyclin-dependent kinase 1 phosphorylation
... by Cdk1, a specific phospho-antibody targeting S130 in p21 was generated and used in various in vitro studies (Figure ...by Cdk1 was recognized by this phospho-antibody and the alanine substitution ...
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Cyclin B2/cyclin dependent kinase1 dissociation precedes CDK1 Thr 161 dephosphorylation upon M phase promoting factor inactivation in Xenopus laevis cell free extract
... ABSTRACT Cyclin-dependent kinase 1 (CDK1) is the enzymatic subunit of M-phase Promoting Factor ...a cyclin B ...of cyclin B is thought to be a direct cause of MPF ...
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Identification of core genes in ovarian cancer by an integrative meta-analysis
... benzimidazoles 1; CAMs: Cell adhesion molecules; CCNB2: G2/mitotic-specific cyclin-B2; CDC20: Cell-division cycle protein 2; CDK1: Cyclin-dependent kinase 1; CENPA: ...
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<p>New Isatin–Indole Conjugates: Synthesis, Characterization, and a Plausible Mechanism of Their in vitro Antiproliferative Activity</p>
... gene 1, cell cycle-associated proteins (cyclin B1, cyclin D1, and phos- phorylated cyclin-dependent kinase 1), and a pro-apoptotic protein (Bcl-2-associated X protein ...
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Penta O galloyl β D glucose induces G1arrest and DNA replicative S phase arrest independently of P21 cyclin dependent kinase inhibitor 1A, P27 cyclin dependent kinase inhibitor 1B and P53 in human breast cancer cells and is orally active against triple negative xenograft growth
... Breast cancer (BCa) is the major cause of cancer-related deaths for women in the US [1] and other Western countries. Approximately 60% to 70% of BCa cases express estrogen receptors (ERs) or progesterone recep- ...
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Regulation of lipogenesis by cyclin dependent kinase 8–mediated control of SREBP 1
... CDK8 and CycC regulate lipid levels and lipogenic gene expression in Dro- sophila. CDK8 and CycC are highly conserved in eukaryotes; thus, we first used Drosophila as a model organism to study function and regulation of ...
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Transcriptional Up-Regulation of the Cyclin D2 Gene and Acquisition of New Cyclin-Dependent Kinase Partners in Human T-Cell Leukemia Virus Type 1-Infected Cells
... with 1 ml of lysis buffer containing 50 mM Tris-Cl (pH ...inhibitor), 1 mM DTT, and 1 mM ...anti-human cyclin D2 antibody C-17 (Santa Cruz Biotechnology catalog ...with 1:1,000 dilution ...
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Regulation of Ciz1 by Cyclin A Cyclin Dependent Kinase 2 (CDK2) mediated phosphorylation
... Cells were trypsinised as described (section 2.2). Following trypsinisation, cells were centrifuged at 500g for minutes to form a pellet, which was then frozen at -80 o C. RNA extraction was performed using the PureLink ...
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Inhibitors of protein kinases affecting cAMP dependent proteolysis of GATA 6
... [11]. Cyclin-dependent kinase (Cdk)1/2 inhibitor III, 4,5,6,7-tetrabromobenzotriazole (TBB), Wortmannin, and 4-cyano-3-methylisoquinoline were obtained from ...
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MicroRNAs in systemic rheumatic diseases
... CDK2, cyclin-dependent kinase 2; EGFL7, epidermal growth factor-like domain 7; IFN, interferon; IL, interleukin; IRAK1, IL-1 receptor- associated kinase 1; MCP-1, monocyte ...
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Retroviral Cyclin Enhances Cyclin-Dependent Kinase-8 Activity
... a cyclin box fold (29, 40, 45, ...a cyclin box fold, which is responsible for binding to cyclin-dependent kinase-8 (CDK8) (9, 29, ...CDK8, cyclin C, and Mediator proteins Med12 ...
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Cyclin dependent kinase regulation in haemopoietic cells
... E2F-1 dependent transcription is inhibited during differentiation of other cell types, CD34+ cells in culture for 5 days have not growth arrested so this explanation may be an ...
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Modulation of apoptosis by the cyclin dependent kinase inhibitor p27Kip1
... permits cyclin-dependent kinase 2 (CDK2) activity to be generated, allowing the cell to enter the S phase, followed by completion of the cell cycle ...
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Downregulation of cyclin dependent kinase 2 activity and cyclin A promoter activity in vascular smooth muscle cells by p27(KIP1), an inhibitor of neointima formation in the rat carotid artery
... to 1 109 c-fos and 2 79 to 1 100 cyclin A gene 5 9 flanking sequence upstream from a promoterless luciferase cDNA, and the expression vector pAC-CMV-p27, were provided by ...
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Landscape of genomic alterations in high-grade serous ovarian cancer from exceptional long- and short-term survivors
... CCNE1: Cyclin E 1; CD4: Cluster of differentiation 4; CD8: Cluster of differentiation 8; CDK12: Cyclin dependent kinase 12; CNV: Copy number variation; DLEU1: Deleted in lymphocytic ...
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Proteomic analysis of differentially expressed proteins in hepatitis B virus-related hepatocellular carcinoma tissues
... protein kinase 1 and Protein ...named Cyclin- dependent kinase inhibitor p12, Cyclin-dependent kinase inhibitor 1, Antioxidant protein 2, Protein disulfide ...
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USP4 function and multifaceted roles in cancer: a possible and potential therapeutic target
... protein kinase B (AKT) and bind to 14-3-3 isoforms to be exported from nucleus to cytoplasm and subsequently exert its deubiquitina- tion capacity ...complex 1-mediated signaling pathways, thus influenced ...
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Friend or foe: emerging role of nuclear factor kappa-light-chain-enhancer of activated B cells in cell senescence
... mutated kinase; CiP, cyclin dependent kinase interacting protein; CDK, cyclin dependent kinase; CycD, cyclin D; DNA, deoxyribonucleic acid; eGFR, epidermal growth ...
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The role of tau in neurodegeneration
... htau, at a physiological concentration, does not reduce anterograde fast axonal transport in isolated squid axo- plasm [64]. However, when axoplasm is perfused with tau isoforms lacking the C-terminus, anterograde (but ...
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