Cyclin dependent kinase 2
![“In silico Molecular Docking studies of 1-substituted-2-((methyl) substituted)-1H-benzo[d]imidazole derivates as Cyclin Dependent Kinase -2 Inhibitors” by Sreenivas Enaganti, R.D.Shailimavardhini, Akkiraju.PavanChand, Pavani Medoju, J.Usharani, G.Kamala,](data:image/gif;base64,R0lGODlhAQABAIAAAP///wAAACH5BAEAAAAALAAAAAABAAEAAAICRAEAOw==)
“In silico Molecular Docking studies of 1-substituted-2-((methyl) substituted)-1H-benzo[d]imidazole derivates as Cyclin Dependent Kinase -2 Inhibitors” by Sreenivas Enaganti, R.D.Shailimavardhini, Akkiraju.PavanChand, Pavani Medoju, J.Usharani, G.Kamala, P.Ravindra reddy, C.S.Karigar, India.
... The cyclin-dependent kinase2 (cdk2) is a key enzyme in the cell cycle machinery of all eukaryotic organisms belongs to the family of conserved serine/threonine protein ...regulatory cyclin partners. ...
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DOCKING AND MOLECULAR DYNAMICS STUDIES ON CHROMONE BASED CYCLIN DEPENDENT KINASE-2 INHIBITORS
... as cyclin dependent kinase-2 ...ligands 2-(3,4-dihydroxyphenyl)-8-(1,1-dioxidoisothiazolidin-2-yl)-3-hydroxy- 6-methyl-4H-chromen-4-one, baicalin, fisetin, flavoperidol, ...
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Cyclin-Dependent Kinase 2 Regulates Foxp3 and Regulatory T Cell Function
... the kinase responsible for this modification was not ...showed cyclin-dependent kinase 2 (CDK2) opposes Treg suppressive function both in vitro and in vivo, but did not determine a ...
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Optimization of luminescent assay for screening of cyclin-dependent kinase 2 inhibitors
... compromised. Cyclin-dependent kinases ensure the tight regulation of the cell cycle execution by mediating phosphorylation of cellular ...the cyclin-dependent kinase 2 activity ...
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Cyclin-dependent kinase 2 is an ideal target for ovary tumors with elevated cyclin E1 expression
... that Cyclin E1 (CCNE1) was overexpressed in 30% of established ovarian cancer cell ...of cyclin-dependent kinase 2 (Cdk2), we investigated the effect of Cdk2 inhibitor on ovary ...
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Downregulation of cyclin dependent kinase 2 activity and cyclin A promoter activity in vascular smooth muscle cells by p27(KIP1), an inhibitor of neointima formation in the rat carotid artery
... of cyclin-dependent kinase 2 (cdk2) activity in serum-deprived VSMCs was associated with the formation of complexes between cdk2 and its inhibitory protein p27(KIP1) ...of cyclin A ...
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Hepatitis B Virus HBx Protein Activation of Cyclin A–Cyclin-Dependent Kinase 2 Complexes and G1 Transit via a Src Kinase Pathway
... references 2 and ...protein kinase (MAPK) path- way (6, 18, 55, 86), the cell stress-induced MEKK1–p38–c-Jun N-terminal kinase (JNK) pathway (8, 73), and the family of Src tyrosine kinases ...
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Differential requirement of cyclin-dependent kinase 2 for oligodendrocyte progenitor cell proliferation and differentiation
... under physiological conditions in the absence of Cdk2 [39] seems sufficient to maintain a normal density of oligo- dendroglial cells in the corpus callosum. However, when challenged with demyelination induced by LPC ...
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Regulation of Ciz1 by Cyclin A Cyclin Dependent Kinase 2 (CDK2) mediated phosphorylation
... 84 Having to measure multiple reactants can also increase the margin of error of the entire system. It also complicates determining the correct parameters required for solving the rate of reaction (Schnell and Mendoza, ...
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Molecular docking and biological evaluation of some thioxoquinazolin-4(3H)-one derivatives as anticancer, antioxidant and anticonvulsant agents
... Results: We evaluated the previously synthesized quinazoline derivatives 1–3 for their anticancer activities against three cancer cell lines (HepG2, MCF‑7, and HCT‑116). Among the tested compounds, quinazolines 1 and 3 ...
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Modulation of apoptosis by the cyclin dependent kinase inhibitor p27Kip1
... permits cyclin-dependent kinase 2 (CDK2) activity to be generated, allowing the cell to enter the S phase, followed by completion of the cell cycle ...
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Silencing or inhibition of H3K79 methyltransferase DOT1L induces cell cycle arrest by epigenetically modulating c-Myc expression in colorectal cancer
... CDK2: Cyclin- dependent kinase 2; ChIP: Chromatin immunoprecipitation; Cimp − : :Low CpG island methylator phenotype; Cimp+: High CpG island methylator phenotype; C-Myc: MYC proto-oncogene, ...
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The role of SCF ubiquitin-ligase complex at the beginning of life
... CCNE1: Cyclin E1; Cdk2: Cyclin-dependent kinase 2; CTB: Cytotrophoblast; EC: Endometrial carcinogenesis; EE2: 17 α -ethinylestradiol; EFS: Empty follicle syndrome; EGA: Embryonic genome ...
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IN SILICO INHIBITION OF PROTO ONCOGENE TYROSINE PROTEIN KINASE SRC (C SRC) BY ARISTOLACTAM A II, 4 ALLYL RESORCINOL AND STIGMAST 4 EN 3, 6 DIONE FOR ANTICANCER ACTIVITY OF PIPER BETLE LINN (PIPERACEAE): TRADITIONAL CLAIM REVALIDATED
... protein kinase Src (c-Src) and Cyclin dependent kinase 2 (CDK2) was selected based on their report of anticancer activity and listing in target prediction report of the selected ...
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Omega 3 polyunsaturated fatty acids inhibit cell proliferation by regulating cell cycle in fad3b transgenic mouse embryonic stem cells
... G1/S-specific cyclin-D1; Ccne1: G1/S-specific cyclin-E1; Cdk2: Cyclin- dependent kinase 2; Cdk4: Cyclin-dependent kinase 4; Cdk6: ...
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Rhomboid domain-containing protein 1 promotes breast cancer progression by regulating the p-Akt and CDK2 levels
... CDK2: Cyclin-dependent kinase 2; CHX: Cycloheximide; DCIS: Ductal carcinoma in situ; ER: Estrogen receptor; ERAD: Endoplasmic reticulum- associated degradation; FACS: Fluorescence Activated ...
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Transcriptional Downregulation of p27KIP1 through Regulation of E2F Function during LMP1-Mediated Transformation
... is dependent upon activation of a specific NF- B complex containing Bcl-3 and dependent upon STAT3 activa- tion (39, ...signal-regulated kinase (ERK) pathways and PI3K, and inhibition of these ...
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Effect of glutamine or glucose deprivation on the expression of cyclin and cyclin-dependent kinase genes in glioma cell line U87 and its subline with suppressed activity of signaling enzyme of endoplasmic reticulum–nuclei-1
... that cyclin-dependent ki- nase-2 associates with and is regulated by the regu- latory subunits of the complex, including cyclin A or E, but activity of cyclin-dependent ...
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MicroRNAs in systemic rheumatic diseases
... CDK2, cyclin-dependent kinase 2; EGFL7, epidermal growth factor-like domain 7; IFN, interferon; IL, interleukin; IRAK1, IL-1 receptor- associated kinase 1; MCP-1, monocyte ...
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<p>New Isatin–Indole Conjugates: Synthesis, Characterization, and a Plausible Mechanism of Their in vitro Antiproliferative Activity</p>
... B1, cyclin D1, and phos- phorylated cyclin-dependent kinase 1), and a pro-apoptotic protein (Bcl-2-associated X protein gene), and activated ...
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