cyclin dependent kinase (CDK)
Cyclin-Dependent Kinase 1/Cyclin B1 Phosphorylates Varicella-Zoster Virus IE62 and Is Incorporated into Virions
... of cyclin-dependent kinase (CDK) ...cellular kinase in VZV replication. CDK activity assays of infected cells revealed a large viral phosphoprotein that was identified as being ...
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Use of cyclin-dependent kinase (CDK) 4/6 inhibitors for hormone receptor-positive, human epidermal growth factor receptor 2-negative, metastatic breast cancer: a roundtable discussion by The Breast Cancer Therapy Expert Group (BCTEG)
... In a previous meeting, the group addressed several key issues related to endocrine therapy for hormone receptor-positive (HR+) early breast cancer (EBC) [1]. A second BCTEG meeting was convened in late August 2017 with ...
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Tumor suppression and inhibition of aneuploid cell accumulation in human brain tumor cells by ectopic overexpression of the cyclin dependent kinase inhibitor p27KIP1
... Abstract To investigate how overexpression of p27KIP1, a downstream effector of TGF-b and a universal cyclin-dependent kinase CDK inhibitor could influence the malignant phenotype of mal[r] ...
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A novel role for the cyclin dependent kinase inhibitor p27Kip1 in angiotensin II–stimulated vascular smooth muscle cell hypertrophy
... termed cyclin-dependent kinases (Cdk’s), and their regu- latory subunits, the cyclins (6, ...D3), cyclin E, and cyclin A play an impor- tant role ...progression; cyclin E/Cdk2 or ...
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Exosomal miRNAs in hepatitis B virus related liver disease: a new hope for biomarker
... 2; CDK: Cyclin dependent kinase; CHB: Chronic hepatitis B; CLD: Chronic liver disease; CLL: Chronic lymphocytic leukemia; CREB: cAMP response element-binding protein; CSF: Cerebrospinal fluid; ...
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Fast food diet-induced non-alcoholic fatty liver disease exerts early protective effect against acetaminophen intoxication in mice
... element; CDK: Cyclin-dependent kinase; CYP2E1: Cytochrome P450 2E1; dUTP: Nick-end labeling; ERK: Extracellular signal-regulated kinase; FF: Fast food; FF-S: Fast food diet mice ...
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Associations of genetic variants of endothelin with cardiovascular complications in patients with renal failure
... of cyclin-dependent kinase (Cdk) which controls the elongation phase of transcrip- tion by RNA polymerase II ...[19]. Cdk is a cell-cycle check point regulator, and one study showed ...
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The detective, prognostic, and predictive value of DNA methylation in human esophageal squamous cell carcinoma
... epoxide; CDK: cyclin-dependent kinase; CHFR: Checkpoint with FHA and ring finger; CRC: colorectal cancer; DACH1: Dachshund homologue 1; DNMT3A: DNA (cytosine-5-)-methyltransferase 3 alpha; ...
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MCPractice-Cells.pdf
... catalysis, catalytic—acceleration of chemical reaction by lowering activation energy CDK—cyclin-dependent kinase cell—basic unit of living organisms cell cycle—stages a cell passes throu[r] ...
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ER-α36: a novel biomarker and potential therapeutic target in breast cancer
... protein kinase B; BCSCs, breast cancer stem cells; cdk 4, cyclin-dependent kinase 4; eR-α36, estrogen receptor-alpha36; eR-α66, estrogen receptor- alpha66; eRes, estrogen response ...
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Notch signaling in pediatric soft tissue sarcomas
... 2; CDK: cyclin-dependent kinase; CNS: central nervous system; CSL: DNA binding protein transcriptional complex; DLL1: Delta-like 1; DLL3: Delta-like 3; DLL4: Delta-like 4; EGR1: Early Growth ...
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Biomarker driven treatment of head and neck squamous cell cancer
... response; CDK: Cyclin dependent kinase; CTC: Circulating tumor cells; ctDNA: Circulating tumor DNA; DNA: Deoxyribonucleic acid; EBV: Epstein Barr virus; EGFR: Epidermal growth factor receptor; ...
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Molecular characterization and targeted therapeutic approaches in breast cancer
... Basal-like; CDK: Cyclin-dependent kinase; CSC: Cancer stem cell; EGFR: Epidermal growth factor receptor; EMT: Epithelial-mesenchymal transition; ER: Estrogen receptor; ESR1 : Estrogen receptor ...
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USP4 function and multifaceted roles in cancer: a possible and potential therapeutic target
... Protein kinase B; ARF-BP1: ARF-binding protein 1; BRAC : Breast invasive carcinoma; CARD: Caspase recruitment domain; CDK: Cyclin-dependent kinase; CypA: Cyclophilin A; DNPEP: PAK5- ...
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Emerging trends in immunotherapy for pediatric sarcomas
... ACT: Adoptive cell therapy; ALC: Absolute lymphocyte count; CAR: Chimeric antigen receptor; CDK: Cyclin-dependent kinase; CTA: Cancer testis antigen; CTL: Cytotoxic T cell; CTLA-4: Cytot[r] ...
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Friend or foe: emerging role of nuclear factor kappa-light-chain-enhancer of activated B cells in cell senescence
... mutated kinase; CiP, cyclin dependent kinase interacting protein; CDK, cyclin dependent kinase; CycD, cyclin D; DNA, deoxyribonucleic acid; eGFR, epidermal ...
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A clinico-genomic analysis of soft tissue sarcoma patients reveals CDKN2A deletion as a biomarker for poor prognosis
... sarcoma; CDK: cyclin-dependent kinase; CDKN2A: cyclin-dependent kinase inhibitor 2A; ctDNA: circulating tumor DNA; COG: Children’s Oncology Group; DDLPS: dedifferentiated ...
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Transcriptional Downregulation of p27KIP1 through Regulation of E2F Function during LMP1-Mediated Transformation
... is dependent upon activation of a specific NF- B complex containing Bcl-3 and dependent upon STAT3 activa- tion (39, ...signal-regulated kinase (ERK) pathways and PI3K, and inhibition of these ...
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Phosphorylation states change Otx2 activity for cell proliferation and patterning in the Xenopus embryo
... possible cyclin-dependent kinase (Cdk) sites and one Akt site, and analyzed the biological activities of phosphomimetic (4E) and nonphosphorylatable (4A) mutants for those ...the Cdk ...
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Omega 3 polyunsaturated fatty acids inhibit cell proliferation by regulating cell cycle in fad3b transgenic mouse embryonic stem cells
... of cyclin D1 and cyclin E in one study [11], but decreased expression of the Cdk2 and cyclin E proteins and induced apoptosis in an- other study ...the cyclin D1/cyclin-dependent ...
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