cyclin dependent kinase inhibitor
The cyclin dependent kinase inhibitor p57Kip2 mediates proliferative actions of PTHrP in chondrocytes
... the cyclin-dependent kinase inhibitor p57 Kip2 is the opposite of the PTHrP- null phenotype, we hypothesized that PTHrP’s proliferative actions in chondrocytes might be mediated by opposing ...
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Cyclin dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis
... Genetic variation at the chromosome 9p21 risk locus promotes cardiovascular disease; however, it is unclear how or which proteins encoded at this locus contribute to disease. We have previously demonstrated that loss of ...
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Penta O galloyl β D glucose induces G1arrest and DNA replicative S phase arrest independently of P21 cyclin dependent kinase inhibitor 1A, P27 cyclin dependent kinase inhibitor 1B and P53 in human breast cancer cells and is orally active against triple negative xenograft growth
... protein kinase), a well-known autophagy signaling kinase in response to nutrient deprivation [18]; and by increased phosphatidylethanolamine modification of the microtu- bule-associated protein 1 light ...
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Pharmacokinetics and biodistribution of the cyclin-dependent kinase inhibitor -CR8- in mice
... cell death induction. The drug passes the BBB at a level sufficient to reach concentrations able to inhibit neur- onal kinase targets. Bone marrow exposure was about 30% of that found as systemic exposure, a ...
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Indirect p53-dependent transcriptional repression of Survivin CDC25C , and PLK1 genes requires the cyclin-dependent kinase inhibitor p21/CDKN1A and CDE/CHR promoter sites binding the DREAM complex
... Regulation of Survivin, CDC25C, and PLK1 by p53 was tested in HCT116 wild-type cells upon stimulation with the DNA damaging agent doxorubicin, the MDM2 inhibitor Nutlin-3a, or the pyrimidine analogue ...
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Cyclin-Dependent Kinase Inhibitor AT7519 as a Potential Drug for MYCN-Dependent Neuroblastoma.
... CDK inhibitor AT7519 in neuroblastoma ...CDK2 inhibitor that binds within the active site cleft of CDK2 overlapping with the ATP-binding pocket (13), it also effectively targets additional kinases including ...
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A novel role for the cyclin dependent kinase inhibitor p27Kip1 in angiotensin II–stimulated vascular smooth muscle cell hypertrophy
... termed cyclin-dependent kinases (Cdk’s), and their regu- latory subunits, the cyclins (6, ...D3), cyclin E, and cyclin A play an impor- tant role ...progression; cyclin E/Cdk2 or ...
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Tumor suppression and inhibition of aneuploid cell accumulation in human brain tumor cells by ectopic overexpression of the cyclin dependent kinase inhibitor p27KIP1
... Abstract To investigate how overexpression of p27KIP1, a downstream effector of TGF-b and a universal cyclin-dependent kinase CDK inhibitor could influence the malignant phenotype of mal[r] ...
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Drosophila Cdi4 is a p21/p27/p57-like cyclin-dependent kinase inhibitor with specificity for cyclin E complexes.
... vitro kinase assays were performed using lysates from baculovirus infected Sf9 cells essentially as described (Kato et ...His6-tagged cyclin E and HA-tagged Cdk2 (provided by ...tagged cyclin A ...
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Modulation of apoptosis by the cyclin dependent kinase inhibitor p27Kip1
... CDK2, cyclin E and cyclin A (antibodies from Santa Cruz Biotechnology) for 60 min at 4°C ...recombinant cyclin E–CDK2 and cyclin A–CDK2 ...CDK2, cyclin E, and cyclin A from a ...
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Restoration of regulatory and effector T cell balance and B cell homeostasis in systemic lupus erythematosus patients through vitamin D supplementation
... CDKN1A: cyclin-dependent kinase inhibitor 1A; ECD: Phycoerythrin-Texas Red; ELISA: enzyme-linked immunosorbent assay; FITC: fluorescein isothiocyanate; FoxP3: forkhead box P3; GSEA: gene set ...
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MicroRNA miR-155 Inhibits Bone Morphogenetic Protein (BMP) Signaling and BMP-Mediated Epstein-Barr Virus Reactivation
... MicroRNA miR-155 is expressed at elevated levels in human cancers including cancers of the lung, breast, colon, and a subset of lymphoid malignancies. In B cells, miR-155 is induced by the oncogenic latency gene ...
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Transformation of SV40-immortalized human uroepithelial cells by 3-methylcholanthrene increases IFN- and Large T Antigen-induced transcripts
... cyclin-dependent kinase inhibitor; TRICK2A: death receptor 5 or DR5 (also Apo2; TRAIL-R2; TRICK2; or KILLER); IAP3: inhibitor of apoptosis protein 3; HSIAH2: inhibitor of ...
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Transcriptional Downregulation of p27KIP1 through Regulation of E2F Function during LMP1-Mediated Transformation
... is dependent upon activation of a specific NF- B complex containing Bcl-3 and dependent upon STAT3 activa- tion (39, ...signal-regulated kinase (ERK) pathways and PI3K, and inhibition of these ...
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Proteomic analysis of differentially expressed proteins in hepatitis B virus-related hepatocellular carcinoma tissues
... protein kinase 1 and Protein ...named Cyclin- dependent kinase inhibitor p12, Cyclin-dependent kinase inhibitor 1, Antioxidant protein 2, Protein disulfide ...
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A clinico-genomic analysis of soft tissue sarcoma patients reveals CDKN2A deletion as a biomarker for poor prognosis
... CDK: cyclin-dependent kinase; CDKN2A: cyclin-dependent kinase inhibitor 2A; ctDNA: circulating tumor DNA; COG: Children’s Oncology Group; DDLPS: dedifferentiated ...
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The role of cancer associated fibroblasts in esophageal cancer
... CKI: cyclin-dependent kinase inhibitor; COX: cyclooxygenase; DFS: disease free survival; EMT: epithelial-mesenchymal transition; EAC: esophageal adenocarcinoma; ESCC: esophageal squamous cell ...
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Omega 3 polyunsaturated fatty acids inhibit cell proliferation by regulating cell cycle in fad3b transgenic mouse embryonic stem cells
... G1/S-specific cyclin-D1; Ccne1: G1/S-specific cyclin-E1; Cdk2: Cyclin- dependent kinase 2; Cdk4: Cyclin-dependent kinase 4; Cdk6: Cyclin-dependent ...
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Friend or foe: emerging role of nuclear factor kappa-light-chain-enhancer of activated B cells in cell senescence
... mutated kinase; CiP, cyclin dependent kinase interacting protein; CDK, cyclin dependent kinase; CycD, cyclin D; DNA, deoxyribonucleic acid; eGFR, epidermal growth ...
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Phosphorylation states change Otx2 activity for cell proliferation and patterning in the Xenopus embryo
... possible cyclin-dependent kinase (Cdk) sites and one Akt site, and analyzed the biological activities of phosphomimetic (4E) and nonphosphorylatable (4A) mutants for those ...Cdk inhibitor ...
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