cyclin dependent protein kinase
Cip/Kip cyclin-dependent protein kinase inhibitors and the road to polyploidy
... One remarkable feature of cells undergoing endocycles is their ability to tolerate genotoxic stress induced either from DNA damage or incomplete DNA replication. In Drosophila, this apparently is due to the absence of a ...
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E2F1-induced upregulation of long noncoding RNA LINC00668 predicts a poor prognosis of gastric cancer and promotes cell proliferation through epigenetically silencing of CKIs
... of cyclin-dependent protein kinase inhibitors (CKIs), including p15, p16, p21, p27 and p57, thus contributing to the regulation of the gastric cancer cell ...
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Friend or foe: emerging role of nuclear factor kappa-light-chain-enhancer of activated B cells in cell senescence
... mutated kinase; CiP, cyclin dependent kinase interacting protein; CDK, cyclin dependent kinase; CycD, cyclin D; DNA, deoxyribonucleic acid; eGFR, epidermal ...
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Penta O galloyl β D glucose induces G1arrest and DNA replicative S phase arrest independently of P21 cyclin dependent kinase inhibitor 1A, P27 cyclin dependent kinase inhibitor 1B and P53 in human breast cancer cells and is orally active against triple negative xenograft growth
... Breast cancer (BCa) is the major cause of cancer-related deaths for women in the US [1] and other Western countries. Approximately 60% to 70% of BCa cases express estrogen receptors (ERs) or progesterone recep- tors ...
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Retroviral Cyclin Enhances Cyclin-Dependent Kinase-8 Activity
... encoding cyclin C is frequently lost, and cell lines derived from these tumors are dependent upon continued cyclin C depletion for growth ...of cyclin C depletion with cancer points to a pos- ...
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Molecular genetics of human primary microcephaly: an overview
... of cyclin-dependent kinase 5 regu- latory subunit-associated protein-2 (CDK5RAP2) have been recognised as the basis of MCPH3 ...This protein is composed of 38 exons encoding 1,893 amino ...
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IN SILICO INHIBITION OF PROTO ONCOGENE TYROSINE PROTEIN KINASE SRC (C SRC) BY ARISTOLACTAM A II, 4 ALLYL RESORCINOL AND STIGMAST 4 EN 3, 6 DIONE FOR ANTICANCER ACTIVITY OF PIPER BETLE LINN (PIPERACEAE): TRADITIONAL CLAIM REVALIDATED
... Plant based compounds serve as curing agents of various disease for decades. Virtual screening using computational tools provide a wide platform of plant based bioactivity prediction. The current study provides molecular ...
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USP4 function and multifaceted roles in cancer: a possible and potential therapeutic target
... shuttling protein which can locate both in the cyto- plasm and ...activated protein kinase B (AKT) and bind to 14-3-3 isoforms to be exported from nucleus to cytoplasm and subsequently exert its ...
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Cyclin dependent kinase regulation in haemopoietic cells
... cellular protein and because the number of dye binding sites are high, the fluorescent signal can be very ...cellular protein using FITC, and the other tube stained for cdc2 using a secondary anti-rabbit ...
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Hepatitis B Virus HBx Protein Activation of Cyclin A–Cyclin-Dependent Kinase 2 Complexes and G1 Transit via a Src Kinase Pathway
... regulatory protein known as HBx (or X protein) (reviewed in references 2 and ...Ras–Raf–mitogen-activated protein kinase (MAPK) path- way (6, 18, 55, 86), the cell stress-induced ...
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Regulation of Ciz1 by Cyclin A Cyclin Dependent Kinase 2 (CDK2) mediated phosphorylation
... this protein has still not been fully ...of protein-protein ...orthologue protein in Drosophila interacts with CDK4 and Rux, a CKI that interacts directly with cyclin B (Jin et ...
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Identification of core genes in ovarian cancer by an integrative meta-analysis
... G2/mitotic-specific cyclin-B2; CDC20: Cell-division cycle protein 2; CDK1: Cyclin-dependent kinase 1; CENPA: Centromere protein A; DEGs: Differentially expressed genes; EGA: The ...
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Omega 3 polyunsaturated fatty acids inhibit cell proliferation by regulating cell cycle in fad3b transgenic mouse embryonic stem cells
... G1/S-specific cyclin-D1; Ccne1: G1/S-specific cyclin-E1; Cdk2: Cyclin- dependent kinase 2; Cdk4: Cyclin-dependent kinase 4; Cdk6: Cyclin-dependent ...
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Motif co-regulation and co-operativity are common mechanisms in transcriptional, post-transcriptional and post-translational regulation
... repeat protein SHOC-2 (SHOC2), which re- sults in a novel myristoylation motif and causes aberrant SHOC2 localisation, provides the sole experimentally characterised example of ex nihilo motif birth on the pro- ...
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Regulatory mechanisms of B cell responses and the implication in B cell-related diseases
... demonstrated that doxycycline withdrawal resulted in suppression of mir-155 expression and subsequent tumor shrinkage [89]. In this mouse model, anti-miR- 155 treatment resulted in decreased tumor burden, indi- cating ...
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Geminivirus-Induced Gene Silencing of the Arabidopsis RETINOBLASTOMA-RELATED
... Removal of RBR’s function as a G1/S checkpoint could shift the majority of cells into G2 where they would continue into mitosis, arrest or undergo endoreduplication. To distinguish these possibilities, we examined the ...
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Effect of Histone Deacetylase (HDAC) Inhibitor on Gene Expression in LNCaP-MST and MCF-7 Cells
... a protein kinase that ensures the suitable execution and fidelity of ...and protein expressions were significantly down-regulated along with down regulation of CDC25C levels after SAHA ...CDK1 ...
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Up-regulation of CNDP2 facilitates the proliferation of colon cancer
... G2/M. Cyclin B1 is one of the key regu- lators of the G2/M transition [26], and gene amplification or overexpression of cyclin B1 is associated with cell growth and tumorigenesis in colon cancer ...[28]. ...
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A Journey in Science: Cell-Cycle Control
... knowledge of the cell cycle is mostly in the arena of cancer. Cancer arises when there is uncontrolled cell division due to damage to the controls regulating the growth of cells and their subsequent reproduction. Without ...
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Reduced Activity of Mutant Calcium Dependent Protein Kinase 1 Is Compensated in Plasmodium falciparum through the Action of Protein Kinase G
... the kinase domain of PfCDPK1 to PfCDPK5 were aligned with Toxo- plasma gondii CDPK1 (TgCDPK1) as a ...the kinase activity of ...chimeric protein identity (Fig. 2C). The in vitro kinase assay ...
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