Cyclo-oxygenase
Effects of selected cyclo-oxygenase inhibitors on cardiovascular preparations in rabbits
... Cyclo-oxygenase- (COX-) inhibitors are those drugs which have the ability to inhibit the activity of COX enzymes (types 1 and 2) resulting in inhibition of prostaglandin synthesis [1]. Two types of COX- ...
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Immunoexpression of constitutive and inducible cyclo-oxygenase isoforms in the rat foetal and maternal digestive tract
... Numerous experimental and clinical studies have shown that cyclo-oxygenase inhibitors, also known as non-steroidal anti-inflammatory drugs, may dam- age the gastrointestinal mucosa. The harmful effect is ...
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First dose analgesic effect of the cyclo oxygenase 2 selective inhibitor lumiracoxib in osteoarthritis of the knee: a randomized, double blind, placebo controlled comparison with celecoxib [NCT00267215]
... of cyclo-oxygenase (COX) [4,5]; this profile also accounts for their common side effects, including gastric irri- tation, renal impairment and inhibition of platelet aggregation ...
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Candida albicansinduces cyclo oxygenase 2 expression and prostaglandin E2 production in synovial fibroblasts through an extracellular regulated kinase 1/2 dependent pathway
... Cyclo-oxygenase 2 (COX-2) expression following co-culture of Cand- ida albicans with synovial fibroblasts. COX-2 expression by synovial fibroblasts was assessed after 12-h co-culture of synovial fibroblasts ...
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Epstein-Barr Virus Protein Can Upregulate Cyclo-Oxygenase-2 Expression through Association with the Suppressor of Metastasis Nm23-H1
... Nm23-H1. Cyclo-oxygenase-2 (COX-2), an inducible enzyme important in inflammation, is overexpressed in a variety of cancers and can influence cell ...
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The Association between Cyclo-oxygenase Inhibitor Medications and Clinical Relapse in Inflammatory Bowel Disease: Review of Current Perspectives
... Arachidonic acid is the precursor for the eicosanoids (that is mediators derived from 20- carbon polyunsaturated fatty acids); these include several families of mediators, predominantly prostaglandin (PG), thromboxane ...
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Mechanisms underlying the growth inhibitory effects of the cyclo oxygenase 2 inhibitor celecoxib in human breast cancer cells
... of cyclo- oxygenase (COX), particularly the COX-2 isozyme, and block- ade of the prostaglandin (PG) cascade may have impacts on neoplastic growth and development by inhibiting several key features of ...
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EVALUATION OF AQUEOUS FRUIT EXTRACT OF TAMARINDUS INDICA (L) FOR INHIBITION OF TUMOR NECROSIS FACTOR a AND CYCLO OXYGENASE ENZYMES IN EXPERIMENTAL ANIMAL
... Vol 11, Issue 3, 2018 Online 2455 3891 Print 0974 2441 EVALUATION OF AQUEOUS FRUIT EXTRACT OF TAMARINDUS INDICA (L) FOR INHIBITION OF TUMOR NECROSIS FACTOR a AND CYCLO OXYGENASE ENZYMES IN EXPERIMENTA[.] ...
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Role of Selective Cyclo Oxygenase 2 Inhibitor Celecoxib in Canine Osteosarcoma Cell Culture
... that cyclo-oxygenase-2 (Cox2) is related to the development and pro- gression of tumors, since this enzyme is induced and expressed by cells such as macrophages, osteoblasts, “activated” endothelial cells, ...
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Cyclo oxygenase 2 selective inhibitors and nonsteroidal anti inflammatory drugs: balancing gastrointestinal and cardiovascular risk
... For complicated gastrointestinal events we chose to use data only from meta-analyses of randomised trials for celecoxib [28], etoricoxib [29], and valdecoxib [30], for rofecoxib we combi[r] ...
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Differential direct effects of cyclo oxygenase 1/2 inhibition on proteoglycan turnover of human osteoarthritic cartilage: an in vitrostudy
... cartilage Shown are the percentage changes compared with healthy cartilage of proteoglycan synthesis rate as a measure of cartilage matrix synthesis pg synthesis; percentage release of n[r] ...
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Dynamic compression counteracts IL 1β induced inducible nitric oxide synthase and cyclo oxygenase 2 expression in chondrocyte/agarose constructs
... IL-1β induced iNOS and COX-2 and inhibited aggrecan expression Figure 2 illustrates the effects of IL-1β on the relative expression levels of iNOS, COX-2, aggrecan and collagen type II i[r] ...
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Hippocampal CA1 βCaMKII mediates neuroinflammatory responses via COX-2/PGE2 signaling pathways in depression
... Results from previous studies have shown that the Ca 2+ -triggered activation of calcium/calmodulin-de- pendent protein kinases type II (CaMKIIs) are related to stress-induced depressive symptoms [3–6]. More- over, ...
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Pharmacological basis for the therapy of pain and inflammation with nonsteroidal anti inflammatory drugs
... Another milestone was the discovery by Vane and co- workers that the analgesic, antipyretic and anti-inflamma- tory properties of acetylsalicylate were based on the inhibition of prostaglandin synthesis [4]. Vane showed ...
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EFFECT OF FICUS HISPIDA IN INFLAMMATORY BOWEL DISEASE IN EXPERIMENTAL ANIMALS
... The inflammatory response initiated by acetic acid includes activation of cyclo-oxygenase and lipooxygenase pathways.17 The FH treated rats showed a dose dependent decrease in macroscopi[r] ...
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Thromboxane A2 Mediates Augmented Polymorphonuclear Leukocyte Adhesiveness
... both cyclo-oxygenase and thromboxane synthetase reduced increases in adherence induced by arachidonic acid (10 µg/ml), suggesting that lipopolysaccharide- mediated increases in adherence were due to an ...
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Cells of the synovium in rheumatoid arthritis Synovial fibroblasts
... CCL = C-C motif ligand; COX = cyclo-oxygenase; CXCL = C-X-C motif ligand; DMARD = disease-modifying antirheumatic drug; FGF = fibroblast growth factor; FLIP = FLICE inhibitory protein; I[r] ...
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KINETIC ESTIMATION OF GABAPENTIN AND ETORICOXIB IN PHARMACEUTICALS
... Etoricoxib 5‐chloro‐2‐[6‐methylpyridine‐3‐yl]‐3[4‐sulfonylphenyl] pyridine) is a novel, selective second generation cyclo‐oxygenase‐ 2 inhibitor administered orally as an analgesi[r] ...
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Developments in the scientific understanding of osteoarthritis
... In recent population studies, genome-wide linkage scans have highlighted several specific genes involved in disease risk [15]. Chromosome 2q was positive in several scans, suggesting that this chromosome is likely to ...
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Association of serum uric acid levels on birth weight, in women with hypertension in pregnancy: A retrospective cohort study
... ANNEXTURE I-ABBREVIATIONS ACOG American college of obstetrics and gynecology APH Antepartum hemorrhage BOH Bad obstetric history CHTN Chronic hypertension Cox -2 Cyclo-oxygenase 2 DBP Di[r] ...
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