Cyclooxygenase 2
Expression of β Catenin and Cyclooxygenase 2 in Colorectal Carcinoma: An Immunohistochemical Study
... cancer-related death worldwide [1,2]. It might be related to a number of predisposing factors including the prior existence of benign tumours (adenomas), the prior existence of ulcerative colitis, inherited syndromes ...
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Induction of cyclooxygenase 2 in human umbilical vein endothelial cells by lysophosphatidylcholine
... induces cyclooxygenase-2 mRNA and protein ...of cyclooxygenase-2 is accompanied by the enhancement of both basal- and calcium ionophore A23187-induced synthesis of ...the ...
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Impacts of Cytosolic Phospholipase A2, 15 Prostaglandin Dehydrogenase, and Cyclooxygenase 2 Expressions on Tumor Progression in Colorectal Cancer
... drogenase (15-PGDH) have been suggested to be related to carcinogenesis of colorectal cancer (CRC). The aim of this study was to investigate the roles of cPLA2, COX-2, mPGES-1, and 15-PGDH in tumor progression. ...
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Prognostic significance of cyclooxygenase 2 (COX 2) expression in patients with surgically resectable adenocarcinoma of the oesophagus
... many, Cat. 740955) following manufacturer's instructions. Total RNA was then reverse-transcribed by using the Promega reverse transcription system (Promega, Southampton, UK, Cat # A3500). The resulting c-DNA was ...
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NFAT and CREB Regulate Kaposi's Sarcoma-Associated Herpesvirus-Induced Cyclooxygenase 2 (COX-2)
... Ca 2⫹ / calmodulin-dependent phosphatase Cn, which regulates NFAT protein translocation from the cytoplasm to the nucleus via dephosphorylation in response to increased levels of intracellular ...PGE 2 ...
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Angiotensin II attenuates renal cortical cyclooxygenase 2 expression
... COX- 2 immunoreactivity expression was stimulated by phor- bol dibutyrate (PDB) administration, preincubation for 24 hours with angiotensin II inhibited this phorbol ester–mediated induction of COX-2 ...
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Immunohistochemical and functional correlations of renal cyclooxygenase 2 in experimental diabetes
... imental model of inflammation, and COX-1 involve- ment was assessed by the incidence of development of lesions in gastric mucosa. The selectivity of NS398 has not been sufficiently tested in hemodynamic and renal ...
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The effect of risedronate on osteogenic lineage is mediated by cyclooxygenase 2 gene upregulation
... Alkaline phosphatase (ALP), a glycoprotein attached to the outer cell membrane by a glycosylphosphatidyli- nositol (GPI) anchor [48], exists as several isoenzymes and many isoforms present in tissues and serum. The ALP ...
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Inhibition of cyclooxygenase 2 aggravates doxorubicin mediated cardiac injury in vivo
... We have previously shown that DX induces cyclooxy- genase (COX) activity in rat neonatal cardiomyocytes (8). COX catalyzes the first step in the conversion of arachidonic acid to prostaglandins (9). Two isoforms of COX ...
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Inhibition of cyclooxygenase 2 in hematopoietic cells results in salt sensitive hypertension
... tion for 15 minutes (T-7186, Sigma-Aldrich). For double-immunofluo- rescent staining of F4/80 with COX-2, MR, or VEGF-C, deparaffinized sections were blocked with 10% normal goat serum plus 2% BSA for 1 ...
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A QSAR Study of 3, 4 Diaryloxazolones as Cyclooxygenase 2 Inhibitors
... Molecular modeling studies were performed using CS Chem office, 2005 molecular modeling software ver. 9.0, supplied by Cambridge Software Company. The structure of each compound was drawn in ChemDraw Ultra 9.0 and copied ...
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Cyclooxygenase/lipoxygenase shunting lowers the anti cancer effect of cyclooxygenase 2 inhibition in colorectal cancer cells
... COX inhibitors are potentially attractive drugs for the chemoprevention of colorectal cancer, and have been reported to induce regression of polyps in patients with familial adenomatous polyposis [24]. Observational ...
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Host cyclooxygenase 2 modulates carcinoma growth
... We found high levels of COX-2 mRNA expressed in stromal fibroblasts of both human and rodent col- orectal cancers (20). It is clear from these results that COX-2 is expressed in both epithelial and tumor ...
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Differential gene expression patterns in cyclooxygenase 1 and cyclooxygenase 2 deficient mouse brain
... the entire dataset with Ingenuity Pathways analysis software (Ingenuity Systems, Redwood City, CA, USA), a web-based software application that assists in the analysis and elucida- tion of complex biologic systems, ...
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Deletion of cyclooxygenase-2 inhibits K-ras–induced lung carcinogenesis
... Furthermore, our findings suggest that COX-2 mediates K-Ras–induced lung cancer through the MAPK pathway. The MAPK/Erk signaling cascade is activated by a wide variety of receptors involved in cell growth and ...
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In vitro evaluation of the synergistic antioxidant and anti inflammatory activities of the combined extracts from Malaysian Ganoderma lucidum and Egyptian Chlorella vulgaris
... pathogenesis of human chronic diseases. One of which stimulators (reactive radicals and proinflammatory medi- ators) can be easily induced by another. Reactive oxygen and nitrogen species (RONS) can induce intracellular ...
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Prostaglandin E2 synthesis in cartilage explants under compression: mPGES 1 is a mechanosensitive gene
... Total RNA (1 µg) was reverse transcribed with Omniscript (Qiagen) in a final volume of 20 µL containing 50 ng of oligos dT. The enzyme was then inactivated by heating and the inter- esting mRNAs (COX-1, genbank BC005573; ...
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Supplement of 5 hydroxytryptophan before induction suppresses inflammation and collagen induced arthritis
... Serum samples were collected from CIA mice at day 36 post-immunization and the concentrations of IL-6, IL-17, TNFα and IFNγ were measured by cytometric bead array kits (BD Biosciences). In other experi- ments, ...
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Membrane associated prostaglandin E synthase 1 is upregulated by proinflammatory cytokines in chondrocytes from patients with osteoarthritis
... in PBS for 30 min at 20–25°C, rabbit anti-human mPGES antibody or goat anti-human COX-2 antibody (diluted 1:100 or 1:200, respectively, in PBS containing 1% albu- min) was added and incubation was performed for ...
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Erlotinib or gefitinib for the treatment of relapsed platinum pretreated non small cell lung cancer and ovarian cancer: a systematic review
... 11 studies which provided separate data for the platinum-refractory cohort, the overall response rate was similar, being 10% (16 responders/ 160 patients) (Shepard et al., 2005; Felip et al., 2008). This suggests that it ...
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