Cyclooxygenase-2 (COX-2)
Cyclooxygenase-2 promotes tumor growth and suppresses tumor immunity
... Cyclooxygenase-2 (COX-2), an inducible form of the enzyme that catalyzes the first step in the synthesis of pros- tanoids, is associated with inflammatory diseases and carcinogenesis, which is ...
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Cyclooxygenase 2 Polymorphisms and Susceptibility to Colorectal Cancer: A Meta Analysis
... A literature research was conducted using PubMed and Web of Science up to December 2012 without language re- strictions. Relevant studies were identified using the terms: (‘cyclooxygenase-2 or COX-2 ...
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Cyclooxygenase 2 and selenium in breast cancer
... Selenium (Se) is well known as an essential trace mineral and an essential cofactor for glutathione peroxidases (GPx), selenoprotein P, and thioredoxin reductase, which are involved in scavenging free radicals and ...
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Cyclooxygenase 2 Expression Is Related to the Epithelial to Mesenchymal Transition in Human Colon Cancers
... Fig. 2. Effects of PMA on the expressions of E-cadherin, COX-2, Snail and 15- PGDH, and cell mobility in HCT8 and ...COX-2, cyclooxygenase-2; GAPDH, glyceraldehydes 3-phosphate ...
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Cyclooxygenase/lipoxygenase shunting lowers the anti cancer effect of cyclooxygenase 2 inhibition in colorectal cancer cells
... by cyclooxygenase (COX), is implicated in the colorectal cancer (CRC) ...of cyclooxygenase-2 ...by cyclooxygenase inhibition and to determine if this process antagonizes the anti-cancer effect ...
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Induction of cyclooxygenase 2 in human umbilical vein endothelial cells by lysophosphatidylcholine
... induces cyclooxygenase-2 mRNA and protein ...of cyclooxygenase-2 is accompanied by the enhancement of both basal- and calcium ionophore A23187-induced synthesis of ...the ...
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Immunohistochemical and functional correlations of renal cyclooxygenase 2 in experimental diabetes
... Immunoblotting. Kidney cortices were finely minced and then disrupted in a glass-glass motor-driven Kontes tissue homogenizer in 10 mM Tris, 1 mM EDTA, 20 µg/ml leupeptin, 20 µg/ml benzamidine, and 40 µ g/ml PMSF. ...
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Angiotensin II attenuates renal cortical cyclooxygenase 2 expression
... COX- 2–positive cells were observed in the vicinity of the macula densa (Figure 3a), but many macula densa cells were unstained (Figure 3a, arrow) and the predominant staining was seen in cTAL cells adjacent to ...
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A QSAR Study of 3, 4 Diaryloxazolones as Cyclooxygenase 2 Inhibitors
... A Quantitative Structure Activity Relationship (QSAR) study of 3, 4-Diaryloxazolones has been performed to evaluate the descriptors responsible for the COX-2 inhibitory activity of the molecules. The molecular ...
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Cyclooxygenase-2 expression in oligodendrocytes increases sensitivity to excitotoxic death
... The previous findings are consistent with a role for COX- 2 contributing to the loss of oligodendrocytes in demyeli- nating lesions. One way in which oligodendrocytes can be lost in demyelinating disease is ...
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Association of Cyclooxygenase 2 Gene Polymorphism in Irritable Bowel Syndrome.
... COX-2 exists as a homodimer, each monomer with a molecular mass of about 70 kDa. The tertiary and quaternary structures of COX-1 and COX-2 enzymes are almost identical. Each subunit has three different ...
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Metal Enhanced Electrochemical Cyclooxygenase-2 (COX-2) Sensor for Biological Applications
... Cyclic voltammetry was used to characterize the elec- trode surface. Oxidizing the silver monolayer in the pres- ence of the goat anti-COX-2 antibody resulted in reactive silver oxides accompanied by electrons ...
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The Role of MicroRNAs in Cyclooxygenase-2 Mediated Breast Cancer Progression
... We have established that COX-2 plays a role in inducing miR-655 expression and tumorsphere formation, but the exact mechanisms remain to be investigated. Wang et al. (2011) showed that transforming growth factor-β ...
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Cyclooxygenase-2 and Ki67 Expression in Oral Leukoplakia: a Clinicopathological Study
... Elevated levels of COX-2 were also observed in the majority of dysplastic squamous epithelia and SCC, in contrast to the weak expression detected in normal esophageal tissue [14]. Another study reported ...
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Immunomodulatory effects of nicotine on interleukin 1β activated human astrocytes and the role of cyclooxygenase 2 in the underlying mechanism
... manner, which in turn interacted with its EP2/4 receptors in an autocrine/paracrine fashion. The same group has also shown that activation of EP2/4 receptors led to an increase in secondary messenger cyclic adenosine ...
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PET imaging of cyclooxygenase-2 (COX-2) in a pre-clinical colorectal cancer model
... However, COX-2 is located inside the membrane of the endoplasmic reticulum. Consequently, radiotracers need to cross various biological membranes to reach the COX- 2 binding site. For this purpose, a ...
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Cyclooxygenase-2 (COX-2) inhibitors: future therapeutic strategies for epilepsy management
... Increasing evidences on the role of inflammation in epilepsy pathogenesis are encouraging researchers to gather informa- tion on the clinical use of neuroinflammation-targeted ther- apeutics and to develop their better, ...
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Cyclooxygenase-2-Dependent Bronchoconstriction in Perfused Rat Lungs Exposed to Endotoxin
... formation and LPS-induced bronchoconstriction were prevented by treatment with the unspecific COX inhib- itor acetyl salicylic acid, the specific COX-2 inhibitor CGP-28238, dexamethasone[r] ...
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Host cyclooxygenase 2 modulates carcinoma growth
... of cyclooxygenase have been char- acterized, COX-1 and ...of cyclooxygenase, the result of other effects, or both. Oshima et al. (2) evaluated COX-2 –/– mice to ...
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Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase 1 or cyclooxygenase 2
... ing of acetic acid–induced gastric ulcers in mice (29). Selective COX-2 inhibitors have no effect on small intestinal crypt survival after irradiation in mice (9). The absence of involvement of COX-2 in ...
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