Cyclophilin A
Cells with High Cyclophilin A Content Support Replication of Human Immunodeficiency Virus Type 1 Gag Mutants with Decreased Ability To Incorporate Cyclophilin A
... human cyclophilin A (CyPA) is incorporated into HIV-1 virions, but not those of other primate immunodeficiency vi- ruses, and that HIV-1 virion incorporation of CyPA is essential to its infectivity (15, ...
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Cyclophilin A Is Localized to the Nucleus and Controls Meiosis in Saccharomyces cerevisiae
... whether cyclophilin A also functions in meiosis and ...that cyclophilin A mutant cells were still capable of undergoing sporulation at a reduced level, indicat- ing that cyclophilin A is important ...
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The control of viral infection by tripartite motif proteins and cyclophilin A
... The relationship between Cyclophilin A (CypA) and HIV- 1 has a long history. CypA is a peptidyl prolyl isomerase that performs cis/trans isomerisation of proline peptide bonds in sensitive proteins. CypA interacts ...
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Evolution of Cyclophilin A and TRIMCyp Retrotransposition in New World Primates
... Aotus cyclophilin A se- quence data (excluding specimens with identical sequences): 1- (((((Homo sapiens, Pan troglodytes), Pongo pygmaeus), (Pa- pio hamadryas, Macaca mulatta)), Cercopithecus aethiops), ...
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Cyclophilin A cooperates with MIP-2 to augment neutrophil migration
... CypA, cyclophilin A; dATP, deoxyadenosine triphosphate; ELISA, enzyme-linked immunosorbent assay; FITC, fluorescein isothiocyanate; FLIPR, fluorescence imaging plate reader; fMLP, formyl-methionyl-leucyl- ...
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Original Article Elevated expression of cyclophilin A in human periodontitis
... Cyclophilin A (CypA), a member of the immu- nophilin family, has peptidyl prolylcis-trans isomerase (PPIase) activity, which regulates immune-modulation, protein folding, trafficking assembly, and cell signaling ...
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Chicken cyclophilin A is an inhibitory factor to influenza virus replication
... It has been reported that chCypA with Mr18 kDa and pI 8.2 [18], approximate to Mr17.8 kDa and pI 8.07 which we predicted from ORF sequence with DNAStar program. Rabbit polyclonal antibodies against chCypA generated with ...
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Plasma level of cyclophilin A is increased in patients with type 2 diabetes mellitus and suggests presence of vascular disease
... factor Cyclophilin A has been demonstrated to be an important secreted oxidative stress induced factor ...[6]. Cyclophilin A is secreted from vascular smooth muscle cells (VSMCs) [7] and endothelial cells ...
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trans-Complementation Rescue of Cyclophilin A-Deficient Viruses Reveals that the Requirement for Cyclophilin A in Human Immunodeficiency Virus Type 1 Replication Is Independent of Its Isomerase Activity
... Human immunodeficiency virus type 1 (HIV-1) requires the incorporation of cyclophilin A (CypA) for replication. CypA is packaged by binding to the capsid (CA) region of Gag. This interaction is disrupted by ...
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Cyclophilin A, TRIM5, and Resistance to Human Immunodeficiency Virus Type 1 Infection
... How might CypA influence HIV-1 CA recognition by re- strictive TRIM5 ␣ orthologues? CypA catalyzes the cis-trans isomerization of peptidyl-prolyl bonds (25). This activity is a rate-limiting step in the refolding ...
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Cyclophilin A from Schistosoma japonicum promotes a Th2 response in mice
... of cyclophilin A from Schistosoma japonicum (AY814078), named as SjCyP18 based on its molecular ...mouse cyclophilin A at the amino acid ...The cyclophilin A homologue found in ...
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Potent Lentiviral Restriction by a Synthetic Feline TRIM5 Cyclophilin A Fusion
... Cyclophilin A (CypA) associates with the HIV-1 capsid (16) and is present in viral particles (10, 34). CypA is a ubiquitous cytoplasmic protein that catalyzes the cis/trans isomerization of peptidyl-prolyl bonds, ...
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SUN1 Regulates HIV-1 Nuclear Import in a Manner Dependent on the Interaction between the Viral Capsid and Cellular Cyclophilin A
... ABSTRACT Human immunodeficiency virus type 1 (HIV-1) can infect nondividing cells via passing through the nuclear pore complex. The nuclear membrane-imbedded pro- tein SUN2 was recently reported to be involved in the ...
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Extracellular cyclophilin A possesses chemotaxic activity in cattle
... Cyclophilin A (CyPA), which is the most abundant member of the family, has multiple biological roles in protein fold- ing, trafficking, T cell activation and cell signaling [5]. CyPA also acts as the intracellular ...
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Cyclophilin A interacts with diverse lentiviral capsids
... Previous reports showed that CsA decreases spreading infections of FIV in cells and in animals [24,25]. However, comparisons with HIV-1 were not done. It has been shown that the infectivity of HIV-1 drops 2–5 fold when ...
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Composition of the Schistosoma mansoni worm secretome: Identification of immune modulatory Cyclophilin A
... mammals, cyclophilin A, is the major cellu- lar target for the immunosuppressive drug cyclosporin A (CsA) as well as newly developed small molecule analogs of CsA that have been shown to limit inflammation and ...
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Characterization of folding cores in the cyclophilin A cyclosporin A complex
... of cyclophilin A with the immu- nosuppressant cyclosporin ...uncomplexed cyclophilin A, to theoretical predictions using a combination of rigidity analysis and coarse-grained simulations of protein ...
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Study of urinary cyclophilin a level in diabetic nephropathy
... ABBREVIATIONS CKD Chronic Kidney Disease ESRD End Stage Renal Disease GFR Glomerular Filteration Rate Cyp A Cyclophilin A DN Diabetic Nephropathy ACR AlbuminCreatinineRatio CVD Cardio Va[r] ...
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The clinical implication of serum cyclophilin A in patients with chronic obstructive pulmonary disease
... Our present study showed that serum CyPA levels were increased in convalescent COPD patients compared to healthy controls, and further elevated in COPD patients with ac[r] ...
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Cyclophilin nomenclature problems, or, 'a visit from the sequence police'
... A search of the LocusLink, HUGO Gene Nomenclature Com- mittee and the NCBI UniGene websites using ‘cyclophilin’, shows 15 putatively functional genes and 22 pseudogenes. The 15 putatively functional gene names ...
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