Cyclosporin A
Cyclosporin A reverses vincristine and daunorubicin resistance in acute lymphatic leukemia in vitro
... malignancy. Cyclosporin A (CsA) completely reverses primary resistance to vincristine and cross resistance to daunorubicin in a pleiotropic drug-resistant subline of human T cell acute lymphatic ...
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CYCLOSPORIN A PRODUCTION BY GENETICALLY IMPROVED FUSANTS OF TOLYPOCLADIUM INFLATUM
... The application of mutagenesis and protoplast fusion protocols are useful for production of the superior genetically improved strains of T. inflatum, which led to produced high levels of cyclosporin A compared to ...
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Preparation and in vitro and in vivo characterization of cyclosporin A-loaded, PEGylated chitosan-modified, lipid-based nanoparticles
... new cyclosporin A-loaded, PEGylated chitosan-modified lipid-based nanoparticle was developed to improve upon the formulation of cyclosporin ...nanoparticles. Cyclosporin A-loaded, PEGylated ...
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Optimizing Fermentation Medium to Produce Cyclosporin a Using Response Surface Methodology
... Optimasi Medium Fermentasi untuk Produksi Cyclosporin A Menggunakan Response Surface Methodology. Response surface methodology (RSM) merupakan model tiga faktorial yang dapat menjelaskan hubungan antar variabel ...
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Cyclosporin A Enhances Callus Formation in Rabbit Tibia Fractures
... by an increased bone formation, have been reported [9,10]. In addition, Orcel et al. found that CsA stimulated bone formation in rat bone and inhibited bone resorption without affecting PTH or vitamin D [12]. In ...
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Cyclosporin A inhibits CD40 ligand expression in T lymphocytes
... with cyclosporin A. Cyclosporin A analogues inhibited CD40 ligand expression with a potency mirroring the ability of each compound to inhibit calcineurin activity, indicating that calcineurin plays a key ...
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Characterization and stability studies of a novel liposomal cyclosporin A prepared using the supercritical fluid method: comparison with the modified conventional Bangham method
... Abstract: A novel method to prepare cyclosporin A encapsulated liposomes was introduced using supercritical fluid of carbon dioxide (SCF-CO 2 ) as an antisolvent. To investigate the strength of the newly developed ...
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Longstanding Obliterative Panarteritis in Kawasaki Disease: Lack of Cyclosporin A Effect
... lins and salicylates, as well as several courses of pulsed methylprednisolone, disease recurred and coronary ar- tery lesions became progressively detectable. Cyclo- sporin A was started and seemed clinically effective. ...
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Absence of the mdr1a P Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A
... and cyclosporin A and, to a lesser extent, morphine across a polarized kidney epithelial cell layer in ...and cyclosporin A, with more moderate effects for dexamethasone (2- to 3-fold) and morphine ...and ...
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Differential effect of cyclosporin A on activation signaling in human T cell lines
... Different T cell lines, which can be induced to secrete interleukin 2 (IL-2) in vitro, were used to dissect the effect of cyclosporin A (CsA). The T leukemia cell Jurkat requires an increase in cytoplasmic calcium ...
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Suppression of feline coronavirus replication in vitro by cyclosporin A
... with cyclosporin A, cyclosporin H, and FK506 We inoculated fcwf-4 cells with FIPV 79 – 1146 at a multi- plicity of infection (MOI) of 1 plaque-forming unit (pfu) per cell to study their effects on FIPV ...
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Characterization of folding cores in the cyclophilin A cyclosporin A complex
... ABSTRACT Determining the folding core of a protein yields information about its folding process and dynamics. The experi- mental procedures for identifying the amino acids that make up the folding core include ...
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Effect of Cyclosporin a on the Tumor Microenvironment
... Tumor angiogenesis is a hallmark of cancer, and plays a critical role in tumor growth, expansion, and metastasis. Both physiological and pathological angiogenesis is assumed to be regulated by the balance between pro and ...
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Preparation and evaluation of cyclosporin A-containing proliposomes: a comparison of the supercritical antisolvent process with the conventional film method
... Abbreviations: scF-ePcs and Film-ePcs, proliposomes containing lipoid ePcs prepared by supercritical fluid of carbon dioxide and conventional film methods; scF-DsPg an[r] ...
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Cyclosporin a Inhibition of experimental autoimmune uveitis in Lewis rats
... Daily treatment with CS-A 10 mg/kg begun on the same day as S-Ag immunization totally inhibited the development of the uveitis in this experimental autoimmune model.. Moreover a greater [r] ...
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MR imaging of reversible cyclosporin A induced neurotoxicity
... On postoperative day 23 16 days after the seizures, T2-weighted MR examination revealed complete resolution of the white matter lesions Fig.. Case 2 A 36-year-old man underwent cardiac t[r] ...
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Effect of cyclosporin A treatment on the production of antibody in insulin dependent (type I) diabetic patients
... either cyclosporin or placebo. Cyclosporin had only minimal effects on the production of anti-islet cell antibodies whether directed to islet cytoplasmic (immunofluorescence) or membrane (cytotoxicity ...
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Supercritical fluid-mediated liposomes containing cyclosporin A for the treatment of dry eye syndrome in a rabbit model: comparative study with the conventional cyclosporin A emulsion
... Abbreviations: AUC, area under the concentration-time curve; AUC 0–24 h , area under the concentration-time curve between 0 and 24 hours; C max , peak drug concentration; CsA, [r] ...
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Etiology of Cortical and White Matter Lesions in Cyclosporin A and FK 506 Neurotoxicity
... Group 2 Mixed Cortical and Subcortical White Matter Lesions Nine BMT patients had mixed lesion morphology, with primarily cortex abnormality and various subcortical and deep white matter[r] ...
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Effects of cyclosporin a on rat skeletal biomechanical properties
... Our results showed that compared with the control group, in the 7.5 mg/kg CsA therapy group the values of the bone volume fraction, the trabecular thickness, and the trabecular number of[r] ...
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