CYP3A4-A
In-vitro assessment of CYP3A4 and CYPC29 inhibition potential of Lupeol using human liver microsomes
... Cytochrome P450 (CYP) is a superfamily of mixed function oxidases that are responsible for the metabolism of many drugs (~ 80%) including anticancer agents. CYP3A4 and CYP2C9 isozymes are responsible for the ...
6
<p>Functional characteristics of CYP3A4 allelic variants on the metabolism of loperamide in vitro</p>
... This is the fi rst study performed to elucidate the enzymatic characteristics of 29 CYP3A4 alleles toward the metabo- lism of loperamide in vitro. Our results fi nd that most of the variants manifest extremely lower ...
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Gut instincts: CYP3A4 and intestinal drug metabolism
... intestinal CYP3A4 activity In an elegant study of intestine- and liver-selective transgenic expression of CYP3A4 on a complete mouse Cyp3a gene knockout background, van Herwaarden et ...intestinal ...
5
Hemodialysis does not alter in vitro hepatic CYP3A4 and CYP2D6 metabolic activity in uremic serum
... Abstract: There is a paucity of studies evaluating the change in liver metabolism in subjects receiving hemodialysis. The purpose of this study was to compare the effect of uremic toxins on hepatic cytochrome P450 ...
7
Inflammation down-regulates CYP3A4-catalysed drug metabolism in hemodialysis patients
... between CYP3A4 activity expressed as quinine/3-OH-quinine and the ratio of 4β-OH-cholesterol/cholesterol; the latter being another marker for CYP3A4 activity [36], no correlation between the inflammatory ...
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Drug-Drug Interactions: Influence of verapamil on the pharmacokinetics of sitagliptin in rats and Ex vivo models
... and CYP3A4) and verapamil (known modulator of P-gp and CYP3A4) using in vivo, ex vivo and in situ ...and CYP3A4 inhibitors (itraconazole and ketoconazole) and ...the CYP3A4- mediated ...
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Nanostructures of diamond, graphene oxide and graphite inhibit CYP1A2, CYP2D6 and CYP3A4 enzymes and downregulate their genes in liver cells
... and CYP3A4 measured separately for all three isoforms and revealing subtle differences among the ...and CYP3A4, all nanostructures inhibited the reaction at similar ...and CYP3A4 was lower in the ...
15
Effect of Honey on CYP3A4 Enzyme and P-Glycoprotein Activity in Healthy Human Volunteers
... ministration on CYP3A4 and P-gp activity in healthy volunteers using carbamazepine and digoxin as their.. 15.[r] ...
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THE HYPOXIC VENTILLATORY RESPONSE AND HEPATIC CYP3A4 UPREGULATION IN HUMAN AT HIGH ALTITUDE
... Study design and protocol: This prospective interventional population pharmacokinetic (pop- PK) study was conducted in healthy male volunteers at a study location geographically 2500m elevated in Tamil Nadu, India. The ...
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FRUIT/VEGETABLE–DRUG INTERACTIONS: PHARMACOKINETIC ASSAY WITH A CYP3A4 SUBSTRATE
... About thirty (30) CYP enzymes responsible for drug metabolism exist in humans. [4-6] It has been documented that 90% of drug metabolism can be attributed to six main enzymes: CYP 1A2, 2C9, 2C19, 2D6, 2E1 and 3A4. [7] ...
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Pharmacokinetic characteristics of telaprevir in healthy Korean male subjects and comparisons with Japanese
... hepatic CYP3A4, ethnic-based genetic differences in the effect of CYP3A4 on the PK of telaprevir may be minimal because allele frequencies of CYP3A4 are similar between the Korean and Japanese ...
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Molecular docking studies of the chemical constituents of hippo 08 with cyp2e1 and cyp3a4
... In the present study, the molecular docking studies of the chemical constituents present in Hippo-08 were carried out with CYP2E1. The compounds like 9,12-octadecadienoic acid, methylester,(E,E)-, ...
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Herbal drug usage with modern medicine 1: Case study of an enzyme inducer, St John’s Wort – Some perspectives
... of CYP3A4 and pgp transporter in tandem to possibly explain the observed low oral bioavailability of ...between CYP3A4 mediated metabolism and pgp mediated transport which restricted the systemic entry of ...
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CYP3A4 mutation causes vitamin D–dependent rickets type 3
... These observations lead to us to propose that a gain-of-func- tion mutation of CYP3A4 causes a distinct form of VDDR. In contrast to the previously described autosomal recessive forms of VDDR that result from ...
7
Functional assessment of <em>CYP3A4</em> allelic variants on lidocaine metabolism in vitro
... on CYP3A4 genetic polymorphisms in the Chinese Han population and this is the first report of all these alleles for lidocaine ...these CYP3A4 allelic isoforms, testosterone, as a probe substrate of ...
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Endosulfan-alpha Induces CYP2B6 and CYP3A4 via the Pregnane X Receptor
... and CYP3A4 proteins induced by ...of CYP3A4 and CYP2B6, respectively, and determine their functionality in catalyzing the metabolism of ...prototypical CYP3A4 inducer, showed an increase in the ...
98
Journal of Applied Pharmaceutical Science
... of CYP3A4–mediated metabolism of midazolam (Mooiman et ...on CYP3A4 varied among different brands of green tea, possibly due to variations in their content of the herbal product's active ingredients ...
7
Original Article Effects of CYP3A4 polymorphisms on efficiency of general anesthesia combined with epidural block in patients undergoing cardiac valve replacement
... of CYP3A4*5 and CYP3A4*6 showed no signifi- cant difference. CYP3A4 played a significant role in drug metabolism and its different activi- ties were suggested to be accountable for indi- vidual ...
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<em>Cytochrome</em> <em>P450 3A4*22</em>, <em>PPAR-α</em>, and <em>ARNT</em> polymorphisms and clopidogrel response
... the CYP3A4*22 allele is not associated with altered clopidogrel ...the CYP3A4*22 variant, it is unlikely that a significantly reduced clopidogrel response could be found in a larger cohort of carriers, ...
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Original Article Association between the CYP3A4 *18B polymorphism and pharmacokinetics of cyclosporine-A in recipients of kidney transplantation in Chinese patients: a meta-analysis of observational studies
... in CYP3A4 and CYP3A5 (the two main isoforms in adults) have varying effects on CsA metabo- ...on CYP3A4 and CYP3A5 genotypes could help to achieve target levels of CsA in blood and avoid CsA-related ...
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