CYP3A5 polymorphism
Effect of CYP3A5 polymorphism on liver function and tacrolimus pharmacokinetics after conversion to a once-daily tacrolimus formulation in stable liver transplant patients
... of CYP3A5 polymorphism on liver function after LT and to characterize the pharmacokinetics of tacrolimus after conversion from a twice-daily regimen to a once-daily extended-release ...the CYP3A5 ...
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<p>Effects of CYP3A5 Polymorphisms on Efficacy and Safety of Tacrolimus Therapy in Patients with Idiopathic Membranous Nephropathy</p>
... with CYP3A5 expresser required higher doses to achieve target blood ...by CYP3A5 polymorphism was further supported by the results that Dose/Weight in CYP3A5 nonexpresser genotype was signi fi ...
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Original Article Genetic analysis of drug-metabolizing enzyme CYP3A5 polymorphisms in Tibetans in China
... diseases. CYP3A5, as one of the most active gene in CYP450 3A superfamily, has become a hot topic in ...of CYP3A5 in Tibetans is rare, we carried the study to explore the genetic polymorphisms of it in one ...
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CYP3A5 polymorphisms in renal transplant recipients: influence on tacrolimus treatment
... of CYP3A5 genetic poly- morphism in influencing tacrolimus dose requirement has been extensively ...studied polymorphism is the SNP 6986A > ...with CYP3A5 enzyme expression. CYP3A5 ...
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The influence of CYP3A5 polymorphisms on haloperidol treatment in patients with alcohol addiction
... variant CYP3A5*3 in Rus- sian population is extremely poor and it probably could influ- ence the results of statistical ...that CYP3A5 6986A > G polymorphism has no statistically significant ...
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Population Pharmacokinetics of Sirolimus in Healthy Chinese Subjects
... P-glycoprotein. CYP3A5 and MDR1 gene polymorphisms have been reported to influence plasma concentrations of this drug and dose requirements, but some recent studies reported conflicting ...for CYP3A5 ...
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Investigation of clinical interaction between omeprazole and tacrolimus in CYP3A5 non-expressors, renal transplant recipients
... Defective CYP3A5 genotype may reveal potential CYP3A4-mediated drug interaction between TAC and ...omeprazole. CYP3A5 may account for more than 50% of whole hepatic CYP3A in individuals who express ...
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Effects of <em>CYP2D6 </em>and <em>CYP3A5 </em>polymorphisms on tamoxifen and its metabolites in Thai breast cancer patients
... and CYP3A5 phenotypes are represented by the CYP2D6 and CYP3A5 polymorphisms, respectively, while the MR (TAM-NDMT) and MR (TAM- 4OHT) are represented by the NDMT and 4OHT concentra- tions, respectively, ...
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Prevalence of <em>CYP2D6*2</em>, <em>CYP2D6*4</em>, <em>CYP2D6*10</em>, and <em>CYP3A5*3</em> in Thai breast cancer patients undergoing tamoxifen treatment
... Asian populations was due to the high prevalence of CYP3A5 polymorphisms in both Caucasians and Asians, including Thais. Moreover, it was found that 20.9% of these patients had only defective alleles, including ...
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EFFECT OF THE CYP3A5 GENETIC POLYMORPHISM ON BLOOD LEVEL TO DOSE RATIO OF CYCLOSPORINE IN THAI RENAL ALLOGRAFT RECIPIENTS
... nucleotide polymorphism (SNP) in intron 3 (*3, 6986 A>G) was found in the CYP3A5 gene, which causes a slicing error and aberrantly spliced mRNA with a premature stop codon result in an absence of ...
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Frequency of CYP3A5 Genetic Polymorphisms and Tacrolimus Pharmacokinetics in Pediatric Liver Transplantation
... In liver transplanted patients, both donor and recipient carrying the CYP3A5 polymorphisms 178. are associated with changes in the pharmacokinetics of TAC[r] ...
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<p>Genetic polymorphisms of CYP3A5, CHRM2, and ZNF498 and their association with epilepsy susceptibility: a pharmacogenetic and case–control study</p>
... in CYP3A5, ZNF498, and CHRM2 genes was inves- tigated in epileptic patients as well as in the healthy individuals to evaluate the association of these variants with epilepsy susceptibility and treatment in ...that ...
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Induction of Cytochrome P450 2A6 by Bilirubin in Human Hepatocytes
... and CYP3A5, UGT1A1, UGT1A3, UGT1A6, UGT2B4, UGT2B7, UGT2B10 and UGT2B15, constitutive androstane receptor (CAR), pregnane X receptor (PXR), retinoid X receptor α (RXRα) and hepatocyte nuclear factor-4α ...
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Identification of the fetal liver cytochrome CYP3A7 in human endometrium and placenta
... cytochromes P450 in human liver, CYP3A. To investigate the possible role in these extrahepatic tissues of the CYP3A microsomal hemoproteins, we analyzed placental and endometrial microsomes on Western blots developed ...
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Cytochrome P450 in living donor liver transplantation
... Similar to the CYP3A family, CYP3A4*18 could be easily identified with PCR-RFLP for DNA sequencing as with CYP3A5*3. A different primer for the PCR assay was used with a forward primer 5′-CACCCTGATGTCCAG- CAGAAA ...
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... the CYP3A5*3/*3 genotype and are classified as ...The CYP3A5*3 allele plays an important role in the pharmacokinetics of tacrolimus (basic therapy for immunosuppression in patients who undergo solid organ ...
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Cytochrome P450 single nucleotide polymorphisms in an indigenous Tanzanian population: a concern about the metabolism of artemisinin based combinations
... CYP3A4*1B, CYP3A5*3 and CYP2B6*6 variant alleles in a Tanzanian indigenous ...length polymorphism (PCR-RFLP) (for CYP2C8*2, CYP2C8*3) and sequencing (for CYP2B6*6, CYP3A5*3 and ...CYP2C8*3, ...
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Original Article The influence of CYP3A4 and CYP3A5 gene polymorphism on individualized medication of FK506 and hepatorenal function after liver transplantation
... and CYP3A5*3 (rs776746) genetic poly- morphism in predicting the efficacy of tacrolimus (FK506) and the recovery of hepatorenal function after liver trans- ...genetic polymorphism of CYP3A4/5 was determined ...
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Effect of estrogen receptor, follicle stimulating hormone and myogenin genes on the performance of Large White sows
... PvuII polymorphism, Follicle Stimulating Hormone Gene (FSHB) HaeIII poly- morphism and Myogenin Gene (MYOG) MspI polymorphism because the effects of these poly- morphisms on reproduction and growth traits ...
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The rs738409 polymorphism of the PNPLA3 gene is associated with hepatic steatosis and fibrosis in Brazilian patients with chronic hepatitis C
... gene polymorphism and steatosis and advanced fibrosis were tested under a recessive inheritance model using logistic regression analysis, including age, gender, BMI, ethnicity/color, HOMA-IR, alcohol intake, HCV ...
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