Cytokine receptor
Original Article Identification of a cytokine-cytokine receptor interaction gene signature for predicting clinical outcomes in patients with colorectal cancer
... the cytokine-cytokine receptor inter- action gene signature can also predict an unfa- vorable prognosis of patients with postopera- tive chemotherapy in the GSE39582 ...
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The human parasite Loa loa in cytokine and cytokine receptor gene knock out BALB/c mice: survival, development and localization
... Results: In mice deficient for IL-4R, IFN-g, IFN-g/IL-5, IL-5 and IL-4R/IL-5, the larvae survived up to 5, 20, 40, 50 and 70 days respectively. Worms recovered 70 days post infection in IL-4R/IL-5 DKO mice were young ...
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Complete blood count data and leukocyte expression of cytokine genes and cytokine receptor genes associated with bovine respiratory disease in calves
... Complete blood counts can aid in the diagnosis of dis- ease; thus, current information regarding the ranges of these values in beef cattle breeds may be useful vet- erinary tools. Our aim was to determine whether these ...
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Suppressor of cytokine signaling 3 is a biomechanical stress–inducible gene that suppresses gp130 mediated cardiac myocyte hypertrophy and survival pathways
... gp130 cytokine receptor activates a cardiomyocyte survival pathway during the transition to heart failure following the biomechanical stress of pressure ...of cytokine signaling 3 (SOCS3), an intrin- ...
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Neuropathies of Stuve-Wiedemann Syndrome due to mutations in leukemia inhibitory factor receptor (LIFR) gene
... CRH2: cytokine receptor homology domains 1 and 2, Ig: Immunoglobulin-like domain; FNIII: fibronectin type III domain (433-530; 541-623; 729-821); TM: transmembrane domain (834-858); CD: cytoplasmic ...
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Original Article Array profiling identified dysregulated miRNAs and target genes and pathways in laryngeal squamous cell carcinoma
... The result of miRNA-Pathway-Network analysis miRNA miRNA style Pathname miRNA miRNA style Pathname miR-30a-5p Down Cytokine-cytokine receptor interaction miR-181d-5p Up Hippo signaling p[r] ...
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STAT3 and STAT1 mediate IL 11–dependent and inflammation associated gastric tumorigenesis in gp130 receptor mutant mice
... gp130 cytokine receptor signaling subunit that cannot bind the negative regulator of cytokine signaling SOCS3 and is characterized by hyperactivation of the signaling molecules STAT1 and STAT3, we ...
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Gene expression profile analyze the molecular mechanism of CXCR7 regulating papillary thyroid carcinoma growth and metastasis
... Chemokines and their receptors are best known for their ability to mediate the direct migration of leukocytes in the immune system. As we all known, a close connec- tion exists between inflammation and cancer. Recently, ...
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Stüve-Wiedemann syndrome: LIFR and associated cytokines in clinical course and etiology
... cardiotrophin-like cytokine factor 1 (CLCF-1, also abbre- viated as CLC) (Figure 3) ...second receptor chain is recruited, either the LIFRβ or the more highly spe- cific OSMRβ ...tor receptor ...
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Effect of a diet enriched with omega-6 and omega-3 fatty acids on the pig liver transcriptome
... a cytokine-cytokine receptor interaction pathway identified by the KEGG database in the DAVID, (see also below) what reflects the anti-inflammatory properties of a high content of omega-3 fatty acids ...
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Serum cytokine profiling analysis for zheng differentiation in chronic hepatitis B
... that cytokine–cytokine receptor interaction, cytosolic DNA‑sensing pathway, and chemokine signaling pathway overlapped between LGDH and LKYD, whereas Toll‑like receptor signaling pathway, ...
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Oestrogen receptor negative breast cancers exhibit high cytokine content
... given in Additional file 1. The tumours included invasive carci- noma, mainly ductal and lobular, and other rare subtypes (mixed ductal and lobular carcinoma, medullary carcinoma and apocrine carcinoma). The tumours were ...
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Vaccination with Adenovirus Serotypes 35, 26, and 48 Elicits Higher Levels of Innate Cytokine Responses than Adenovirus Serotype 5 in Rhesus Monkeys
... of cytokine responses following vaccina- tion with Ad5 revealed only low levels of antiviral and proinflam- matory cytokine and chemokine induction on day 1 following vaccination ...1 receptor ...
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Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohorts
... unbalanced cytokine release brought about by inter- feron regulatory factor 3 (IRF3) and the release of type I interferon-α and -β ...of cytokine release upon LPS- stimulation ...the cytokine release ...
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Nuclear import pathway of the cytokine interleukin-5 and its receptor subunits
... If it does, this should further contribute to the growing idea that polypeptide ligand/receptor nuclear import is a key means of activating specific growth factor and cytokine signalling[r] ...
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Assessment of Lactobacillus gasseri as a Candidate Oral Vaccine Vector
... The cytokine/chemokine profile induced by ...the cytokine milieu will need to be studied in more detail to determine its consequences on downstream immune ...
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Arterial inflammation in mice lacking the interleukin 1 receptor antagonist gene
... antiinflammatory cytokine, interleukin 1 receptor antagonist (IL-1ra), develop lethal arterial inflammation involving branch points and flexures of the aorta and its primary and sec- ondary ...
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Crystal structure of the TRANCE/RANKL cytokine reveals determinants of receptor ligand specificity
... the receptor activator of NF-kB, and its ligand RANKL (initially termed TRANCE, also termed ODF and OPGL), are a TNF superfamily receptor-ligand pair that govern the development and function of osteoclasts, ...
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Myeloid derived suppressor cells – a new therapeutic target in the treatment of cancer
... key receptor to a cytokine that is as- sociated with suppression of the cytotoxic immune re- sponse, may also lead to decreases in accumulation of monocytic and granulocytic MDSC, reduction in tumor growth ...
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Pattern recognition receptor-mediated cytokine response in infants across 4 continents⋆
... The first few years of life represent a period of marked susceptibility to infectious diseases. 1-3 Such vulnerability reflects a state of age-dependent suboptimal immune-mediated protection in early life. 1,4,5 Around ...
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