Cytolytic T lymphocyte
Abnormal cytolytic activity of lymphocyte function associated antigen 1 deficient human cytolytic T lymphocyte clones
... The involvement of the lymphocyte function-associated antigen-1 LFA-1 membrane molecule in cytolytic T lymphocyte CTL interactions with lymphoid target cells was investigated using CTL c[r] ...
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Immunological ignorance of an E7-encoded cytolytic T-lymphocyte epitope in transgenic mice expressing the E7 and E6 oncogenes of human papillomavirus type 16.
... However, cytolytic T-lymphocyte (CTL)-mediated responses to HPV are rarely detectable in patients with cervical ...the T-cell response is deficient during the HPV-induced transformation, we ...
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Antiretroviral Cytolytic T-Lymphocyte Nonresponsiveness: FasL/Fas-Mediated Inhibition of CD4+ and CD8+ Antiviral T Cells by Viral Antigen-Positive Veto Cells
... CTL, cytolytic T lymphocyte; pCTL, CTL precursor; minor H, minor histocompatibility antigen; MHC, major histocompatibility complex; LPS, lipo- polysaccharide; RA, 9-cis-retinoic acid; IL, ...
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Vγ4+ T Cells Promote Autoimmune CD8+ Cytolytic T-Lymphocyte Activation in Coxsackievirus B3-Induced Myocarditis in Mice: Role for CD4+ Th1 Cells
... myocarditis. T-cell-deficient mice develop minimal car- diac injury despite high virus titers in the heart ...of T-cell responses have been found in coxsack- ievirus B3 (CVB3)-induced ...V␥4 T-cell ...
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Analysis of the cytolytic T-lymphocyte response to herpes simplex virus type 1 glycoprotein B during primary and secondary infection.
... JENNINGS1 2,3* Department of Microbiology and Immunology, 1 Center of Excellence for Arthritis and Rheumatology, 4 and Center for Excellence in Cancer Research and Education,2 Louisiana [r] ...
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Cloned long-term cytolytic T-lymphocyte line with specificity for an immediate-early membrane antigen of murine cytomegalovirus.
... 57, 1986 class I glycoproteins encoded by genes of the K or DL loci of the murine major histocompatibility complex MHC 13, 27, simian virus 40-transformed cell lines 14 derived from the [r] ...
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Control of Murine Cytomegalovirus in the Lungs: Relative but Not Absolute Immunodominance of the Immediate-Early 1 Nonapeptide during the Antiviral Cytolytic T-Lymphocyte Response in Pulmonary Infiltrates
... triggering cytolytic activity of effector cells via the cross-linking of surface CD3 or TCR (28, ...pulmonary lymphocyte population isolated from the lungs of uninfected BMT ...peptide-specific T ...
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Characterization of the Cytolytic T-Lymphocyte Response to a Candidate Vaccine Strain of Equine Herpesvirus 1 in CBA Mice
... allow cytolytic activity to develop, as demonstrated previously for other herpesviruses (14, 28, 42, ...no cytolytic activity was detected in the CLN at any time during ...
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Molecular basis for cytolytic T-lymphocyte recognition of the murine cytomegalovirus immediate-early protein pp89.
... Domains and epitopes of a protein antigen recognized by CD8+ T lymphocytes can be defined either by the expression of protein fragments in target cells 37-39, 43 or by incubation of targ[r] ...
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Cytolytic T-lymphocyte responses to respiratory syncytial virus: effector cell phenotype and target proteins.
... The RS virus target protein specificity of CD8+ CTL derived after one or two stimulations in vitro was investigated in A20-1.11 cells infected with recombinant vaccinia viruses expressin[r] ...
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Monitoring of Antigen-Specific Cytolytic T Lymphocytes in Cancer Patients Receiving Immunotherapy
... TAA-specific T-cell responses following immunotherapy, and particularly after the administration of natural or synthe- tic anticancer vaccines, have been studied in patients with can- cer (28, 34, ...
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Suppressive effects of sodium fluoride on cultured splenic lymphocyte proliferation in mice
... splenic T lymphocytes, interleukin-2 (IL-2) and interferon gamma (IFN-γ) in vivo and in vitro; no systematic studies have been reported on the effects of fluoride toxicity on splenic T and B lymphocytes, ...
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Improved proliferation of antigen-specific cytolytic T lymphocytes using a multimodal nanovaccine
... Abstract: The present study investigated the immunoenhancing property of our newly designed nanovaccine, that is, its ability to induce antigen-specific immunity. This study also evaluated the synergistic effect of a ...
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Phenotypic and functional characterization of human cytolytic T cells lacking expression of CD5
... and lymphocyte function-associated antigen 3, but not against CD5, inhibited cytolytic ...CD5- T lymphocytes represent a normal lymphoid ...in T cell activation when present, these CD5- CTL ...
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T lymphocyte response to flavivirus infections
... Thus "T cell tolerance would be a quantitive phenomemon determined in part by self ligand concentrations on cells concerned with self tolerance imposition, and not solely related to affi[r] ...
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Cytotoxic T lymphocyte responses to Ras protein
... induction of antibody responses was unaffected by the nature of the promotor used for expression of the foreign gene. In one study both PF (early) and P L ll(late) vaccinia promoters stimulated influenza HA expression ...
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Cytolytic Activity of the Human Papillomavirus Type 16 E711-20 Epitope-Specific Cytotoxic T Lymphocyte Is Enhanced by Heat Shock Protein 110 in HLA-A*0201 Transgenic Mice
... C ervical cancer (CaCx) is the second leading cause of cancer deaths among women worldwide. CaCx is strongly associated with human papillomavirus (HPV) infection, particularly HPV types 16 and 18. Several clinical ...
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Prognostic performance of lymphocyte-to-monocyte ratio in diffuse large B-cell lymphoma: an updated meta-analysis of eleven reports
... or CCL-5 produced by tumor cells, fibroblasts, or immune cells) recruit monocytes in the tumor microenvironment. As soon as these cells encounter chemokines, tumor-associated macrophages are quickly differentiated from ...
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Effective Cytotoxic T Lymphocyte Targeting of Persistent HIV 1 during Antiretroviral Therapy Requires Priming of Naive CD8+ T Cells
... naive” T cells and memory CD4 ⫹ and CD8 ⫹ T cells obtained post-cART to generate “DC-stimulated memory” T cells at a dC:T (ratio of DC-primed naive T cell to DC- stimulated memory T ...
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Studies on human T lymphocyte colonies
... Ab antibody alpha-medium alpha modified Eagles medium B-CLL chronic lymphocytic leukemia of B lymphocytes D o radiation dose reducing survival to 377 Con A concanavalin A E-rosette sheep[r] ...
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