cytolytic T lymphocytes
Antigenic drift as a mechanism for tumor evasion of destruction by cytolytic T lymphocytes
... P1A-reactive T cells, we isolated the genomic DNA from two recurrent ...nontransgenic T cell–treat- ed mice was fully susceptible to BbsI while being resist- ant Fnu4HI and ...specific T cells, no ...
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Improved proliferation of antigen-specific cytolytic T lymphocytes using a multimodal nanovaccine
... Abstract: The present study investigated the immunoenhancing property of our newly designed nanovaccine, that is, its ability to induce antigen-specific immunity. This study also evaluated the synergistic effect of a ...
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Host immune response to cytomegalovirus: products of transfected viral immediate-early genes are recognized by cloned cytolytic T lymphocytes.
... Our data provide evidence that the IE antigens of MCMV and the Epstein-Barr virus antigens, with the tacit assumption that lymphocyte-detected membrane antigen is a part of the latent in[r] ...
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Mechanism of escape of endogenous murine leukemia virus emv-14 from recognition by anti-AKR/Gross virus cytolytic T lymphocytes.
... In this study we show that when virus is isolated from emv-11+ emv-14- AKXL-21 mice and used to infect the virus-negative SC-1 fibroblast cell line transfected with the H-2Kb gene SC.Kb [r] ...
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Three epitopic peptides of the simian immunodeficiency virus Nef protein recognized by macaque cytolytic T lymphocytes.
... The epitopic peptides are located in the central region of the protein, and all of them show high homology with peptides of the human immunodeficiency virus type 1 Nef protein recognized[r] ...
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Cytolytic T lymphocytes specific for tumors and infected cells from mice with a retrovirus-induced immunodeficiency syndrome.
... Because of the novel sequences defined for the p12- and p15-encoding regions of the gag gene of the defective virus 1, 3, 14 and our finding that LP-BM5infected but not LP-BM5-derived ec[r] ...
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Brain-infiltrating cytolytic T lymphocytes specific for Theiler's virus recognize H2Db molecules complexed with a viral VP2 peptide lacking a consensus anchor residue.
... infection. The latter, TMEV-susceptible mouse strains, de- velop a chronic, progressive form of demyelination similar both clinically and pathologically to human multiple sclerosis (MS). TMEV-infected mice provide an ...
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Late-phase expression of a murine cytomegalovirus immediate-early antigen recognized by cytolytic T lymphocytes.
... First, presentation of IE target antigen is not correlated with intranuclear presence of the major IE protein, but rather with its synthesis, and second, infected fibroblasts are suscept[r] ...
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Identification of multirestricted immunodominant regions recognized by cytolytic T lymphocytes in the human immunodeficiency virus type 1 Nef protein.
... We have also used synthetic peptides to sensitize target cells in a functional assay 26 and defined several antigenic regions amino acid sequences containing more than one T-cell epitope[r] ...
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Monitoring of Antigen-Specific Cytolytic T Lymphocytes in Cancer Patients Receiving Immunotherapy
... TAA-specific T-cell responses following immunotherapy, and particularly after the administration of natural or synthe- tic anticancer vaccines, have been studied in patients with can- cer (28, 34, ...
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Characterization of an immunosuppressive parvovirus related to the minute virus of mice.
... Using virus purified from an EL-4G- cell supernatant by terminal dilution, we have isolated a parvovirus related to MVM which inhibits the generation of cytolytic T lymphocytes in mixed [r] ...
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Modulation of acute and latent herpes simplex virus infection in C57BL/6 mice by adoptive transfer of immune lymphocytes with cytolytic activity.
... The adoptive transfer of cytolytic T lymphocytes derived from in vitro cultures after restimulation with HSV-infected, syngeneic stimulator cells exhibiting class I H-2-restricted, L3T4-[r] ...
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The Cell Biology of Systemic Hyperinflammation Resulting from Failed Cytolytic Target Cell Killing
... All the other FHL mutations appear to affect some aspect of cytotoxic granule exocytosis, resulting in impaired target cell killing by cytolytic T lymphocytes CTLs and/or natural killer [r] ...
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Dendritic cells are defective in breast cancer patients: a potential role for polyamine in this immunodeficiency
... by T cell mediated immunity in the control of tumour growth has been established over recent ...TA-specific T cells requires optimal antigen presentation and T-cell ...naïve T ...
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Induction of anti-leukemic responses by stimulation of leukemic CD3+ cells with allogeneic stimulator cells
... alloreactive T cells could cross react with tumor cells, another possibility is that the alloreactive responses activate T cells specific for tumor associated ...example, T cells reac- tive with ...
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Abnormal cytolytic activity of lymphocyte function associated antigen 1 deficient human cytolytic T lymphocyte clones
... The involvement of the lymphocyte function-associated antigen-1 LFA-1 membrane molecule in cytolytic T lymphocyte CTL interactions with lymphoid target cells was investigated using CTL c[r] ...
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Transformation of T-lymphocyte subsets by Marek's disease herpesvirus.
... The larger number of cell lines obtained from lymphocytes harvested during the cytolytic phase compared with the number of cell lines developed from local lesions during the latent phase[r] ...
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Cytotoxic T cells isolated from the central nervous systems of mice infected with Theiler's virus.
... Since maximum cytolytic activity as measured by LDCC was detected from lymphocytes isolated from the CNS 7 days following infection of resistant mice, this experimental paradigm was used[r] ...
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Loss of ARPC1B impairs cytotoxic T lymphocyte maintenance and cytolytic activity
... The Arp2/3 complex colocalizes with actin at the immune synapse in CTLs. To address the role of the ARP2/3 complex in CD8 CTLs, we made use of the well-characterized OT-I transgenic mouse model in which all T ...
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Cooperativity of HIV-Specific Cytolytic CD4 T Cells and CD8 T Cells in Control of HIV Viremia
... and cytolytic CD4 ⫹ T cells were very similar in many ...to cytolytic activity of CD8 ⫹ T cells, also best characterizes cytolytic CD4 ⫹ T cells (7, 31, ...⫹ T cell ...
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